Wasagamack and Garden Hill First Nations in Island Lake, Manitoba, are experiencing a housing crisis, with severe overcrowding. This article describes a research analysis of local materials, building skill levels, environment, demographics, and cultural aspects completed by graduate students in interior design as part of collaborative design/build activities, training programs, and community workshops. This study is part of a First Nation community/university partnership. Healthy, culturally appropriate, resilient single- and extended-family homes were designed using local materials and labour. This pilot project offers a pathway to build capacity to fill the gap of 150,000 homes in a way that advances cultural, health, social, and economic development. Further, a decolonizing policy and the provision of adequate infrastructure, such as access roads, in Indigenous reserves are needed to create a sustainable home-building ecosystem.