2024
DOI: 10.21203/rs.3.rs-4336966/v1
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Minocycline alleviates microglial ferroptosis by inhibiting HO-1 during cerebral ischaemia reperfusion injury

Lin Wang,
Yao Wang,
Mengyue Wu
et al.

Abstract: Objective Ischaemic stroke is a leading cause of death and disability in individuals worldwide. Cerebral ischaemia reperfusion injury (CIRI) usually leads to severe secondary injury and complications following reperfusion therapy. Microglia play critical roles in the inflammatory reaction of CIRI. However, less attention has been given to microglial death in this process. Our study aimed to explore microglial death in CIRI and the effect and mechanism of minocycline treatment on microglia Methods A middle ce… Show more

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