Minocycline and benign intracranial hypertension

Comprehensive Behavioral Testing in the R6/2 Mouse Model of Huntington's Disease Shows No Benefit from CoQ10 or Minocycline

“…Studies in humans have shown little or no toxicity in the doses tested although minor to significant toxic side effects have also been observed in humans including lupus erythematosus-like syndrome, hepatitis, vestibular disturbance, candida infection, gastrointestinal disturbance, urticaria and benign intracranial hypertension [58], [59], [60], [61], [62], [63], [64], [65], [66], [67]. Importantly, in two studies with ALS patients taking high doses of minocycline -of up to 400 mg/day- observations of elevated hepatic enzymes, faster deterioration in the ALS functional measures, and a trend towards a faster decline in forced vital capacity and higher mortality have been reported [68], [69].…”

Minocycline-Induced Fulminant Intracranial Hypertension

“…The only other case in the literature with loss of visual acuity was a 16-year-old girl who had taken minocycline for 6 weeks and had bilateral hemorrhagic papilledema and initial visual acuity of 2/10 OD and 5/10 OS. 5 The CSF opening pressure was 90 cm of water and a lumboperitoneal shunt was performed. Visual acuity 1 week after the shunt had improved to 4/10 OD and 7/10 OS; the final visual acuity was not provided, although the authors indicated that the "clinical condition continued to improve.…”

“…3 However, there are a few cases reported in the literature with severe papilledema and some vision loss requiring surgical intervention. 4,5 Herein, we describe a unique case of minocycline-induced elevated ICP presenting as fulminant IIH with severe and progressive visual loss, despite withdrawal of the antibiotic.…”

Systemic Antibiotics for Acne

“…Hepatotoxicity (jaundice and fatty infiltration), well known with large doses of intravenous tetracycline, is not a problem for acne with tetracycline and doxycycline, but minocycline sometimes causes severe hepatitis: as of April 1994, 16 patients were reported of whom 2 died in the UK [28]. Benign intracranial hypertension (dizziness, lethargy, headache, nausea, vomiting, photophobia, diplopia and papilledema) is possible for all tetracyclines but resolves upon discontinuation of the drug [29, 30, 31, 32, 33]; the association with isotretinoin enhances this side effect. Fixed drug eruptions are rare but often involve the glans penis [34, 35, 36]; a cross-reactivity is frequent between tetracycline and doxycycline whose formulas are very close, but it is rarer between tetracycline and minocycline whose formulas are more different (fig.…”