Minocycline for the treatment of cutaneous silicone granulomas

Senet, Patricia; Bachelez, Hervé; Ollivaud, L.; Vignon-Pennamen, D; Dubertret, Louis

doi:10.1046/j.1365-2133.1999.02853.x

Cited by 75 publications

(51 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, we have recently reported striking remissions of noninfectious granulomatous disorders with minocycline therapy, such as siliconeinduced cutaneous granulomas, showing that the antiinflammatory properties of tetracyclines documented in vitro may be relevant in vivo. 16 Minocycline toxicity was minimal in the present study, except in 1 black patient with myasthenia gravis and insulin-requiring diabetes mellitus, who developed a drug hypersensitivity syndrome. Since the incidence of minocycline-related hypersensitivity has been claimed to be higher in patients with autoimmune disorders than in control patients and in black patients than in white patients, 21 it would be warranted to exclude these conditions from future trials using minocycline.…”

Section: Commentmentioning

confidence: 84%

“…15 These results obtained in vitro have been the rationale basis for the successful use of minocycline and doxycycline in granulomatous dermatoses, such as silicone-induced subcutaneous granulomas 16 and granulomatous cheilitis. 17 The results of the present study support the efficacy of both minocycline and doxycycline in patients affected with cutaneous sarcoidosis following a long-term course.…”

Section: Commentmentioning

confidence: 99%

See 1 more Smart Citation

The Use of Tetracyclines for the Treatment of Sarcoidosis

Bachelez¹,

Senet²,

Cadranel³

et al. 2001

Arch Dermatol

233

106

View full text Add to dashboard Cite

Section: Commentmentioning

confidence: 84%

Section: Commentmentioning

confidence: 99%

The Use of Tetracyclines for the Treatment of Sarcoidosis

Bachelez¹,

Senet²,

Cadranel³

et al. 2001

Arch Dermatol

233

106

View full text Add to dashboard Cite

“…Also minocycline, which is postulated to be an anti-inflammatory and immunomodulatory drug, is reported to be effective [14, 15]. Another therapeutic approach is to suppress intralesional cell growth by injections of 5-fluorouracil [15]. Surgical intervention is only recommended for well-circumscribed nodular lesions [5].…”

Section: Discussionmentioning

confidence: 99%

Surgery for Foreign Body Reactions due to Injectable Fillers

2006

View full text Add to dashboard Cite

Background: An increasing number of soft tissue fillers have been introduced to the beauty market and these filler substances are widely used as non-toxic, non-immunogenic and relatively harmless injectable alternatives to surgical rejuvenation. Generally, facial fillers are injectable – or surgically insertable – products that are used to fill up the volume loss in the aging face. Depending on bioavailability, chemical composition and degradation, fillers can be classified as temporary or permanent, organic or inorganic and autologous or heterologous. Objective: A plethora of new products has swamped the beauty market since face rejuvenation has become socially acceptable as well as affordable to a wider population, but adverse reactions cannot be excluded. We present 4 patients with complications after injection of facial fillers [including Artecoll®(polymethylmethacrylate microspheres), Restylane® (hyaluronic acid), DermaLive® (hyaluronic acid plus acrylic hydrogel particles) and Newfill® (polylactic acid)] and surgical correction. Results: Surgical intervention led to good aesthetic and functional results after multiple unsuccessful conservative therapies. Conclusion: We recommend that only physicians familiar with the injection techniques and the biological and chemical characteristics of the various injectable products should perform such interventions. Especially permanent fillers should be used with utmost reticence in cosmetic surgery and we would recommend their application only in reconstructive procedures. Additionally, documentation and reporting of all adverse effects must be mandatory.

show abstract

“…Though difficult to remove surgically, siliconomas respond favorably to multiple injections of corticosteroid [7] or antimitotic agents [58]. The wrinkles and lips of thousands of patients in Europe and Asia have been treated successfully with the micro-droplet technique with small amounts of medical-grade silicone fluid.…”

Section: Silicone Fluidmentioning

confidence: 99%

Human Histology and Persistence of Various Injectable Filler Substances for Soft Tissue Augmentation

Lemperle

Morhenn

Charrier³

2003

Aesthetic Plastic Surgery

456

311

View full text Add to dashboard Cite

Abstract. An increasing number of soft tissue filler substances have been introduced to the beauty market outside the U.S. which lack experimental and clinical data in support of their claim. Ten commercially available filler substances were examined for biocompatibility and durability: 0.1 cc of each substance was injected deep intradermally into the volar forearm of one of the authors and observed for clinical reaction and permanence. At 1, 3, 6, and 9 months the test sites were excised, histologically examined, and graded according to foreign body reactions classification. Collagen (Zyplast) was phagocytosed at 6 months and hyaluronic acid (Restylane) at 9 months. PMMA microspheres (Artecoll) had encapsulated with connective tissue, macrophages, and sporadic giant cells. Silicone oil (PMS 350) was clinically inconspicuous but dissipated into the tissue, causing a chronic foreign body reaction. Polylactic acid microspheres (New-Fill) induced a mild inflammatory response and had disappeared clinically at 4 months. Dextran microspheres (Reviderm intra) induced a pronounced foreign body reaction and had disappeared at 6 months. Polymethylacrylate particles (Dermalive) induced the lowest cellular reaction but had disappeared clinically at 6 months. Polyacrylamide (Aquamid) was well tolerated and remained palpable to a lessening degree over the entire testing period. Histologically, it dissipated more slowly and was kept in place through fine fibrous capsules. Polyvinylhydroxide microspheres suspended in acrylamide (Evolution) were well tolerated, slowly diminishing over 9 months. Calcium hydroxylapatite microspheres (Radiance FN) induced almost no foreign body reaction but were absorbed by the skin at 12 months.Host defense mechanisms react differently to the various filler materials, but all substances-resorbable or nonresorbable-appeared to be clinically and histologically safe, although all exhibit undesirable side effects. Since the mechanism of late inflammation or granuloma formation is still unknown, early histological findings are not useful in predicting possible late reactions to filler substances.

show abstract

Minocycline for the treatment of cutaneous silicone granulomas

Cited by 75 publications

References 10 publications

The Use of Tetracyclines for the Treatment of Sarcoidosis

The Use of Tetracyclines for the Treatment of Sarcoidosis

Surgery for Foreign Body Reactions due to Injectable Fillers

Human Histology and Persistence of Various Injectable Filler Substances for Soft Tissue Augmentation

Contact Info

Product

Resources

About