Minocycline-induced acute interstitial nephritis.

Rg, Walker; Thomson, Napier M.; Dowling, John P.; Ogg, C S

doi:10.1136/bmj.1.6162.524

Cited by 38 publications

(7 citation statements)

References 3 publications

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“…However, with the exception of toxoplasmosis no association with uveitis is known in these conditions [O'Connor. 1974;Ruley and Lisi, 1974;Winer et al, 1977;Walker et al, 1979;Knepshieldet al, 1969;Joppich et al, 1975].…”

Section: Review Of the Literature And Discussionmentioning

confidence: 99%

“…Several drugs are now also incriminated as possible causes of acute interstitial ne phritis [Knepsbield et al, 1969;Ruley and Lisi. 1974;Ooi et al, 1975;Walker et al, 1979;Proesmans et al, 1981]. Occasionally interstitial nephritis has been associated with systemic or immune-related syndromes [Andres and McCluskey, 1975;Bergstein and hitman, 1975;Joppich et al, 1975;Boltone t al., 1976;Kinge t al., 1976;Winer et al, 1977;Levy et al, 1979], We report here the case of a patient with acute tubulo-interstitial nephritis accom panied by uveitis and compare our data with those of 9 previously reported patients in whom the same associa tion was found [Guignard and Torrado, 1974;Dobrin et al, 1975;Guesry and Loirat.…”

Section: Introductionmentioning

confidence: 99%

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Acute Tubulo-Interstitial Nephritis and Uveitis Syndrome (TINU Syndrome)

Vanhaesebrouck¹,

Carton²,

Bel³

et al. 1985

Nephron

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Acute renal failure due to tubulo-interstitial nephritis developed in a 15-year-old girl. The disease was accompanied by uveitis and an inflammatory syndrome, consisting of a markedly increased erythrocyte sedimentation rate and high serum gamma globulin levels. The nephropathy as well as the inflammatory syndrome subsided spontaneously. A topical antiphlogistic treatment healed the ocular disease, which has not relapsed so far. The association of acute tubulo-interstitial nephritis and acute uveitis observed in several patients has led to the identification of a specific syndrome with a very particular symptomatology and course, the so-called TINU syndrome, the interest of which resides in the predictability of the complete reversibility of the nephropathy either spontaneously or after steroid treatment, contrasting with the marked tendency towards relapse of the uveitis. The demonstration of circulating immune complexes in the serum during the acute phase of the illness, as in our patient, further points to the involvement of immune processes in the syndrome, but the origin and pathogenesis remain as yet unknown.

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Section: Review Of the Literature And Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Tubulo-Interstitial Nephritis and Uveitis Syndrome (TINU Syndrome)

Vanhaesebrouck¹,

Carton²,

Bel³

et al. 1985

Nephron

View full text Add to dashboard Cite

show abstract

“…Previous cases of minocycline- or tetracycline-induced AIN in adolescents and adults had been treated successfully with steroids, but some patients may require hemodialysis. 4 , 11 , 12 , 14 – 16 …”

Section: Discussionmentioning

confidence: 99%

“… 7 , 8 In patients who have renal failure, minocycline does not accumulate but may aggravate uremia. 9 , 10 Literature search showed only rare reports of isolated AIN or chronic interstitial nephritis associated with minocycline 2 , 4 , 11 – 13 and very few cases with concomitant liver or systemic involvement ( Table 1 ). 14 , 15 However, physicians should be aware of the potential adverse effects of minocycline because these may include life-threatening complications and chronic comorbidities such as the need for hemodialysis or liver transplant ( Table 1 ).…”

Section: Introductionmentioning

confidence: 99%

Severe acute interstitial nephritis secondary to minocycline use in an adolescent girl

Sharma

Geagan

Tengsupakul

2020

SAGE Open Medical Case Reports

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Acute interstitial nephritis is an uncommon but classic complication of minocycline therapy for acne. A 14-year-old African American girl was started on oral minocycline for the treatment of acne 6 weeks before presentation. After 4 weeks on minocycline, she developed a generalized rash, anasarca, fever, myalgia, nausea, vomiting, sore throat, and generalized body weakness. The evaluation showed increased levels of serum creatinine, urea nitrogen, and serum alanine and aspartate aminotransferases. Renal ultrasonography showed bilateral enlarged, echogenic kidneys, and percutaneous renal biopsy showed features of acute allergic interstitial nephritis. Treatment included methylprednisolone and intravenous fluids and discontinuation of minocycline. The elevated serum creatinine level (12.9 mg/dL (reference, 0.40–0.70 mg/dL)) suggests marked renal impairment corresponding with Kidney Disease Improving Global Outcomes acute kidney injury classification stage 3. The kidney injury improved from stage 3 to stage 1 within 3 days, and early treatment with steroids might have prevented chronic renal failure. The creatinine level promptly decreased to normal, and liver enzyme results also improved. In summary, the diagnosis of acute interstitial nephritis should be considered in patients who present with renal failure associated with recent use of minocycline, and treatment with corticosteroids should be considered early during the hospitalization.

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“…Acute interstitial nephritis is a rare complication of tetracycline therapy and there have been two case reports associated with minocycline [1,2]. In both cases the patients presented within 2 weeks of commencing the antibiotic with an acute febrile illness and loin pain, and an acute interstitial nephritis was confirmed on renal biopsy.…”

Section: Introductionmentioning

confidence: 98%