Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome

Hepatotoxicity in 2011: advancing resolutely

“…On the other hand, in the multivariate analysis of factors with a potential impact on serious hepatotoxicity outcomes in DILIN, alcohol use during the previous 12 months behaved as a protective factor (OR = 0.33) (5). Autoimmune hepatitis represents a particularly difficult issue when it comes to differentiate it from idiosyncratic hepatotoxicity, since both conditions lack specific markers and some drugs induce autoimmune hepatitis-like syndromes (minocycline, nitrofurantoin, and methyldopa) (47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59). Other drugs such as interferon alfa or anti-TNF-alfa antibodies may unmask latent autoimmune hepatitis.…”

Minocycline-Induced Lupus in Adolescents: Clinical Implications for Physical Therapists

“…8,9 Identification of medication-induced signs and symptoms and appropriate and timely referral by physical therapists may prevent patients from being subjected to prolonged illness and disability, invasive investigations and treatments, and potentially detrimental medication use. 24,30,33,46 As physical therapists strive toward the goals of Vision 2020 3 and toward recognition as providers of choice for musculoskeletal dysfunctions, their ability to perform pharmacovigilance will become even more vital.…”

“…23,34,41,47 Despite the mechanism, once the offending medication is discontinued, the effects of DIL typically begin to resolve immediately and completely resolve within a few weeks to months. 1,24,34,41 Since the initial description of DIL, as many as 70 medications have been linked to DIL, accounting for up to 10% of the cases of lupus annually in the United States. 41,44 41 Other commonly prescribed medications such as angiotensin-converting enzyme inhibitors and statins are suspected of having a link with DIL, but significant evidence to support these suspicions is lacking to date.…”

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

“…Among these, minocycline, a drug used to treat acne, has been frequently associated with liver autoimmunity [73][74][75] . Interestingly, when minocycline treatment is stopped, the AIH-like syndrome disappears.…”