Minocycline‐induced hyperpigmentation of tympanic membrane, sclera, teeth, and pinna

Abstract

A 40-year-old woman was referred by her primary care physician for evaluation after a routine physical exam revealed bilateral brownish pigmentation of the tympanic membrane. Head and neck examination in the otolaryngology clinic revealed bluish hue of both sclera, teeth, and portions of her pinnae. A hearing test revealed bilateral mild sensorineural hearing loss. The patient had a history of taking minocycline for 14 years, and the hyperpigmentation that she had is known to be a rare complication of prolonged minocycline use. However, to our knowledge, this is the first case showing photographic evidence of minocycline-induced tympanic membrane hyperpigmentation. Minocycline-induced hyperpigmentation should be considered when a patient presents with brown or blue discoloration of the tympanic membrane.

Association between blood volatile organic aromatic compound concentrations and hearing loss in US adults

“…Upon matching, the types of medications taken by participants were primarily focused on treating conditions such as diabetes, hypertension, infections, and hyperlipidemia, among others. As detailed information regarding participants’ medication, including dosage, duration, administration method, and brand was unavailable, we relied on clinical drug experience and existing literature evidence to primarily define participants taking the following 11 drugs (acetaminophen [ 21 ], hydrocodone [ 22 ], ciprofloxacin [ 23 ], phenytoin [ 24 ], levofloxacin [ 25 ], rifampin [ 26 ], minocycline [ 27 ], aspirin [ 28 ], metronidazole [ 29 ], nitroglycerin [ 30 ], and bumetanide [ 31 ]) as a high-risk group for drug-induced hearing loss and subsequently excluded them from the study ( n = 46).…”