Minocycline inhibits angiogenesis in vitro through the translational suppression of HIF-1α

Jung, Hui-Jung; Seo, Incheol; Jha, Bijay Kumar; Suh, Seong-Il; Suh, Min-Ho; Baek, Won-Ki

doi:10.1016/j.abb.2013.12.023

Cited by 26 publications

(22 citation statements)

References 59 publications

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“…These authors also reported that minocycline can inhibit the activity of matrix metalloproteinase (MMPs) 85) . Li et al showed that minocycline can accelerate breakdown of hypoxia-inducible factor-1 (HIF-1) and inhibit hypoxia-induced neovasculogenesis 86) .…”

Section: The Effect Of Dental Treatments and Materials On Angiogenesimentioning

confidence: 96%

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Effect of biomaterials on angiogenesis during vital pulp therapy

2016

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This review intended to provide an overview of the effects of dental materials, used in dentin-pulp complex and dental pulp regeneration, on angiogenesis processes during regenerative endodontic procedures. An electronic search was performed in PubMed and MEDLINE databases via OVID using the keywords mentioned in the PubMed and MeSH headings for English language published articles from January 2005–April 2014 that evaluated the angiogenic properties of different dental materials used in regenerative endodontic procedures. Of the articles identified in an initial search, only 40 articles met the inclusion criteria set for this review. Vital pulp therapy materials might have positive effects on angiogenesis events, while most of the canal irrigating solutions and antibiotic pastes have anti-angiogenic activity except for EDTA. Future clinical studies will be helpful in defining the mechanisms of action for dental materials that promote or inhibit angiogenesis events at applied areas.

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Section: The Effect Of Dental Treatments and Materials On Angiogenesimentioning

confidence: 96%

“…Jung et al demonstrated that minocycline has anti-angiogenic activity due to suppression of the hypoxia-induced vascular endothelial growth factor (VEGF) expression 85) . These authors also reported that minocycline can inhibit the activity of matrix metalloproteinase (MMPs) 85) .…”

Section: The Effect Of Dental Treatments and Materials On Angiogenesimentioning

confidence: 99%

Effect of biomaterials on angiogenesis during vital pulp therapy

2016

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“…Although antibiotic treatment may also improve symptoms in idiopathic forms of ASD 239–241 , ASD with regressive features may be resistant to minocycline therapy 242 . The exact immunomodulatory mechanisms of minocycline are unknown; however, it may exert its effects through a combination of suppressing cytokine signalling, enhancing neurotrophic factor secretion and suppressing mTOR signalling 243 . Minocycline could relieve ASD-related phenotypes directly through altering neural function or indirectly through ameliorating ongoing immune dysfunction or through regulating the intestinal microbiota 241 .…”

Section: Perspectivementioning

confidence: 99%

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

2015

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Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD). Several ASD risk genes encode components of the immune system and many maternal immune system-related risk factors — including autoimmunity, infection and fetal reactive antibodies — are associated with ASD. In addition, there is evidence of ongoing immune dysregulation in individuals with ASD and animal models of this disorder. Recently, several molecular signalling pathways have been identified that link immune activation to ASD phenotypes, including pathways downstream of cytokines, hepatocyte growth factor receptor (MET), MHCI molecules, microglia and complement factors. These findings indicate that the immune system is a point of convergence for various ASD-related genetic and environmental risk factors.

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“… 2006 ; Jung et al. 2014 ). However, overexpression of HIF promotes glycolysis providing energy for cells, but also leads to the accumulation of lactic acid, resulting in the increase of lactic acidosis and necrosis (Blum et al.…”

Section: Discussionmentioning

confidence: 99%

The effects of icariin on the expression of HIF-1α, HSP-60 and HSP-70 in PC12 cells suffered from oxygen–glucose deprivation-induced injury

Zhai

et al. 2017

Pharmaceutical Biology

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Context: The effects of icariin, a chief constituent of ﬂavonoids from Epimedium brevicornum Maxim (Berberidaceae), on the levels of HIF-1α, HSP-60 and HSP-70 remain unknown.Objective: To explore the effects of icariin on the levels of HSP-60, HIF-1α and HSP-70 neuron-specific enolase (NSE) and cell viability.Materials and methods: PC12 cells were treated with icariin (10−7, 10−6 or 10−5 mol/L) for 3 h (1 h before oxygen–glucose deprivation (OGD) plus 2 h OGD). HSP-60, HIF-1α, HSP-70 and NSE were measured using enzyme-linked immunosorbent assay (ELISA). Cell viability was determined by metabolic 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.Results: After 2 h OGD, levels of HIF-1α, HSP-60, HSP-70 and NSE were increased significantly (HIF-1α: 33.3 ± 1.9 ng/L, HSP-60: 199 ± 16 ng/L, HSP-70: 195 ± 17 ng/L, NSE: 1487 ± 125 ng/L), and cell viability was significantly decreased (0.26 ± 0.03), while icariin (10−7, 10−6, or 10−5 mol/L) significantly reduced the contents of HIF-1α, HSP-60, HSP-70 and NSE (HIF-1α: 14.1 ± 1.4, 22.6 ± 1.8, 15.7 ± 2.1, HSP-60: 100 ± 12, 89 ± 6, 113 ± 11, HSP-70: 139 ± 9, 118 ± 7, 95 ± 9 and NSE: 1121 ± 80, 1019 ± 52, 731 ± 88), and improved cell viability (0.36 ± 0.03, 0.38 ± 0.04, 0.37 ± 0.03) in OGD-treated PC12 cells.Discussion and conclusion: These results indicate that the protective mechanisms of icariin against OGD-induced injury may be related to down-regulating the expression of HIF-1α, HSP-60 and HSP-70.

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Minocycline inhibits angiogenesis in vitro through the translational suppression of HIF-1α

Cited by 26 publications

References 59 publications

Effect of biomaterials on angiogenesis during vital pulp therapy

Effect of biomaterials on angiogenesis during vital pulp therapy

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

The effects of icariin on the expression of HIF-1α, HSP-60 and HSP-70 in PC12 cells suffered from oxygen–glucose deprivation-induced injury

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