Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus

Ahmed, Aiesha; Misrani, Afzal; Tabassum, Sidra; Yang, Li; Long, Cheng

doi:10.1016/j.brainresbull.2021.05.028

Cited by 16 publications

(8 citation statements)

References 90 publications

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“…Microglia activation is well recognized in various SD regimens [21][22][23]. Likewise, our data of increased microglia density, altered microglial morphology, and upregulated transcription of a plethora of proin ammatory components suggest that 72 h SD primes microglia activation and neuroin ammation in the adolescent striatum.…”

Section: H Sd Activates Striatal Microglia In Adolescent Micesupporting

confidence: 67%

“…A growing body of evidence strongly links microglial activation with SD-induced cognitive impairments [21][22][23] as well as the pathophysiology of various psychiatric illnesses [25]. Microglia activation and subsequent neuroin ammatory events cause substantial in uences on neuronal activity and behavioral de cits related to affected regions [44].…”

Section: H Sd Primed Microglia Activation and Neuroin Ammation In The...mentioning

confidence: 99%

“…An explicit role of microglia, the resident immunocompetent cells in the central nervous system (CNS), has been discovered in the scenario of insu cient sleep. For example, SD elicits microglia activation and neuroin ammation [21][22][23]. Notably, we have reported that during development, sleep loss halts essential neural maturing processes executed by microglia including compromised microglia-mediated synaptic pruning in sleep-deprived adolescent mice [22,24].…”

Section: Introductionmentioning

confidence: 96%

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Sleep Deprivation Induces Dopamine System Maladaptation and Escalated Corticotrophin-Releasing Factor Signaling in Adolescent Mice

et al. 2023

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Sleep disruption is highly associated with the pathogenesis and progression of a wild range of psychiatric disorders. Furthermore, appreciable evidence shows that experimental sleep deprivation (SD) on humans and rodents evokes anomalies in the dopaminergic (DA) signaling, which are also implicated in the development of psychiatric illnesses such as schizophrenia or substance abuse. Since adolescence is a vital period for the maturation of the DA system as well as the occurrence of mental disorders, the present studies aimed to investigate the impacts of SD on the DA system of adolescent mice. We found that 72 h SD elicited a hyperdopaminergic status, with increased sensitivity to the novel environment and Amphetamine (Amph) challenge. Also, altered neuronal activity and expression of striatal DA receptors were noticed in the SD mice. Moreover, 72 h SD in uenced the immune status in the striatum, with reduced microglial phagocytic capacity, primed microglial activation, and neuroin ammation. The abnormal neuronal and microglial activity were putatively provoked by the enhanced corticotrophinreleasing factor (CRF) signaling and sensitivity during the SD period. Together, our ndings demonstrated the consequences of SD in adolescents including aberrant neuroendocrine, DA system, and in ammatory status. Sleep insu ciency is a risk factor for the aberration and neuropathology of psychiatric disorders.

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Section: H Sd Activates Striatal Microglia In Adolescent Micesupporting

confidence: 67%

Section: H Sd Primed Microglia Activation and Neuroin Ammation In The...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Sleep Deprivation Induces Dopamine System Maladaptation and Escalated Corticotrophin-Releasing Factor Signaling in Adolescent Mice

et al. 2023

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“…A neglected but crucial problem is that gamma power may change dynamically and vary as a function of exact brain region, behavior states, and degree of alertness state. Previous study reported that increased gamma oscillations were associated with increased immobility time during TST in sleep deprivation depression model (Ahmed et al, 2021 ). Furthermore, we explored local field potential in DRN during TST and first reported that gamma oscillation was related to despair-like behaviors ( Figures 1D,E ).…”

Section: Discussionmentioning

confidence: 91%

Electrophysiological Characteristics of Dorsal Raphe Nucleus in Tail Suspension Test

Zhou

Liú

Xie

et al. 2022

Front. Behav. Neurosci.

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The dorsal raphe nucleus (DRN) is a major source of serotonin in the central nervous system, which is closely related to depression-like behaviors and is modulated by local GABAergic interneurons. Although serotonin neurons are known to be activated by struggling behavior in tail suspension test (TST), the exact electrophysiological characteristics are still unclear. Here, we combined in vivo electrode recording and behavioral test to explore the mice neuron electrophysiology in DRN during TST and observed that gamma oscillation was related to despair-like behaviors whereas burst fraction was crucial for survival-like behaviors. We reported the identification of a subpopulation of DRN neurons which change their firing rates when mice get into and during TST immobile states. Both increase (putative despair units, D units for short) and decrease (putative survival units, S units for short) in firing rate were observed. Furthermore, using optogenetics to identify parvalbumin-positive (PV+) and serotonin transporter-positive (SERT+) neurons, we found that SERT+ neurons were almost S units. Interestingly, those that have been identified PV+ neurons include ~20% of D units and ~50% of S units. These results suggest that electrophysiological characteristics incorporated in despair-like behavior studies can provide new insight into the study of anti-depression targets, and GABAergic interneuron is a complex key hub to the coding and regulation of local neural network.

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“…Sleep deprivation in mice induces hippocampal neuroinflammation, which is a risk factor for depression ( Kang et al, 2021 ). Sleep deprivation over-activated microglia in the mouse brain and causes a decrease in the level of anti-inflammatory factors associated with the hippocampus, which may be a possible cause of its depression ( Ahmed et al, 2021 ). Among college students, as sleep quality deteriorates, the level of depression also increases., and the risk of depressive symptoms in students with poor sleep quality was 3.28 times ( Çelik et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Hypertension, sleep quality, depression, and cognitive function in elderly: A cross-sectional study

Chen

Chen²,

Mao³

et al. 2023

Front. Aging Neurosci.

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BackgroundHypertension, sleep disorders, and depression are highly prevalent in the elderly population and are all associated with cognitive impairment, but the role that sleep quality and depression play in the association between hypertension and cognitive impairment is unclear. The aim of this study was to investigate whether sleep quality and depression have a mediating role in the association between hypertension and cognitive impairment.MethodsA cross-sectional study was conducted to collect data from the Tongji Hospital Comprehensive Geriatric Assessment Database. Sleep quality, depression and cognitive function were measured by the Pittsburgh Sleep Quality Index (PSQI), the Geriatric Depression Scale (GDS-15) and the Mini-Mental State Examination (MMSE), respectively. Correlation analysis, regression analysis and Bootstrap analysis were used to examine correlations between key variables and mediating effects of sleep quality and depression. Adjustments for multiple comparisons were performed using Benjamini-Hochberg adjustment for multiple testing.ResultsA total of 827 participants were included, hypertension was present in 68.3% of the sample. After correcting for covariates, hypertensive patients aged 65 years or older had worse cognitive function, poorer-sleep quality and higher levels of depression. Sleep quality was significantly negatively associated with depression and cognitive function, while depression was negatively associated with cognitive function. Mediation analysis revealed that hypertension can affect cognitive function in older adults through a single mediating effect of sleep quality and depression and a chain mediating effect of sleep quality and depression.ConclusionThis study found that sleep quality and depression can mediate the relationship between hypertension and cognitive function in elderly. Enhanced supervision of sleep quality and depression in elderly patients with hypertension may be beneficial in maintaining cognitive function.

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Minocycline inhibits sleep deprivation-induced aberrant microglial activation and Keap1-Nrf2 expression in mouse hippocampus

Cited by 16 publications

References 90 publications

Sleep Deprivation Induces Dopamine System Maladaptation and Escalated Corticotrophin-Releasing Factor Signaling in Adolescent Mice

Sleep Deprivation Induces Dopamine System Maladaptation and Escalated Corticotrophin-Releasing Factor Signaling in Adolescent Mice

Electrophysiological Characteristics of Dorsal Raphe Nucleus in Tail Suspension Test

Hypertension, sleep quality, depression, and cognitive function in elderly: A cross-sectional study

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