Minocycline Modification of Gelatin-Hydroxylapatite Composite by Co-Precipitation Method

Abstract

Minocycline, a semi-synthetic tetracycline antibiotic, was incorporated into gelatin- hydroxyapatite (HA) composite by using a biomimetic co-precipitation method, Firstly, a certain amount of acidic solution of hydroxyapatite was added into gelatin solution dropwise. After that, different amounts of minocycline (0mg, 50mg, 100mg, 200mg, 300mg) solution was added into the reaction system respectively , and obtain the hydroxyapatite - gelatin- minocycline composite. The results showed that the amount of the minocycline impacted the structure of the composite, and minocycline affects HA crystal growth by maybe bonding to 300 face. The approach described here may provide a basis for the preparation of an antibacterial biomaterial for bone regeneration.