Minor adverse effects of galvanic vestibular stimulation in persons with stroke and healthy individuals

Utz, Kathrin S.; Korluss, Kathia; Schmidt, Lena; Rosenthal, Alisha; Oppenländer, Karin; Keller, Ingo; Kerkhoff, Georg

doi:10.3109/02699052.2011.607789

Cited by 83 publications

(55 citation statements)

References 40 publications

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“…Underneath the mastoids the vestibular nerve projects from the inner ear over the vestibular brain stem nuclei into the whole thalamo-cortical vestibular network including area 2cv, 3a,b, parietal area 7a, and the parietoinsular-vestibular-cortex (PIVC) as the "controlling" instance of the network (Lopez et al, 2012). Not unimportant in the clinical context, GVS is painless, easily applicable, safe, and induces minimal side effects, if any, when used in accordance with standard safety guidelines (Utz et al, 2011). As the vestibular system is involved in many sensory processes and projects to several motor, sensory and "higher", multimodal brain regions in the frontal, parietal and temporal cortices (Lopez et al, 2012), it makes GVS an attractive tool to modulate different aspects of this widely distributed network, including different aspects of attention.…”

Section: Galvanic-vestibular Stimulation (Gvs) As An Attractive Tool mentioning

confidence: 99%

Effects of non-invasive brain stimulation on attention: Current debates, cognitive studies and novel clinical applications

Harvey

Kerkhoff

2015

Neuropsychologia

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Section: Galvanic-vestibular Stimulation (Gvs) As An Attractive Tool mentioning

confidence: 99%

Effects of non-invasive brain stimulation on attention: Current debates, cognitive studies and novel clinical applications

Harvey

Kerkhoff

2015

Neuropsychologia

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“…26,35 GVS, unlike caloric vestibular stimulation, is easier to use, lacks adverse side effects, and is more appropriate for repetitive treatment without habituation effects. 36,37 In practice, weak direct currents are delivered via 2 electrodes of different polarity (anode and cathode) placed on both mastoids behind the ears. 38 GVS activates the whole thalamocortical system up to the parieto-insular-vestibular-cortex, 38,39 which is partly damaged in neglect.…”

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Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect

Schmidt

Keller

Utz

et al. 2013

Neurorehabil Neural Repair

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Background. Disturbed arm position sense (APS) is a frequent and debilitating condition in patients with hemiparesis after stroke. Patients with neglect, in particular, show a significantly impaired contralesional APS. Currently, there is no treatment available for this disorder. Galvanic vestibular stimulation (GVS) may ameliorate neglect and extinction by activating the thalamocortical network. Objective. The present study aimed to investigate the immediate effects and aftereffects (AEs; 20 minutes) of subsensory, bipolar GVS (M = 0.6 mA current intensity) on APS in stroke patients with versus without spatial neglect and matched healthy controls. Methods. A novel optoelectronic arm position device was developed, enabling the precise measurement of the horizontal APS of both arms. In all, 10 healthy controls, 7 patients with left-sided hemiparesis and left-spatial neglect, and 15 patients with left hemiparesis but without neglect were tested. Horizontal APS was measured separately for both forearms under 4 experimental conditions (baseline without GVS, left-cathodal/right-anodal GVS, right-cathodal/left-anodal GVS, sham GVS). The immediate effects during GVS and the AEs 20 minutes after termination of GVS were examined. Results. Patients with neglect showed an impaired contralateral APS in contrast to patients without neglect and healthy controls. Left-cathodal/right-anodal GVS improved left APS significantly, which further improved into the normal range 20 minutes poststimulation. GVS had no effect in patients without neglect but right-cathodal/left-anodal GVS worsened left APS in healthy participants significantly. Conclusions. GVS can significantly improve the impaired APS in neglect. Multisession GVS can be tested to induce enduring therapeutic effects.

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“…For example, the proposed intensity of real motion stimulation is now usually a calming rocking instead of vertiginous swinging and efforts are made to investigate and apply GVS at a sub-sensory threshold with remarkable results (Wilkinson et al, 2010). But even above threshold, if GVS is applied with caution, there are mild side effects and these are of transient nature (Utz et al, 2011). Moreover, repeated treatment sessions may be needed for a satisfying outcome and the safety seems to be warranted when using "low-intensity" (1 mA) GVS (Wilkinson et al, 2009).…”

Section: Methodological and Ethical Considerations Of Vestibular Stimmentioning

confidence: 99%

The Moving History of Vestibular Stimulation as a Therapeutic Intervention

2015

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Although the discovery and understanding of the function of the vestibular system date back only to the 19th century, strategies that involve vestibular stimulation were used long before to calm, soothe and even cure people. While such stimulation was classically achieved with various motion devices, like Cox's chair or Hallaran's swing, the development of caloric and galvanic vestibular stimulation has opened up new possibilities in the 20th century. With the increasing knowledge and recognition of vestibular contributions to various perceptual, motor, cognitive, and emotional processes, vestibular stimulation has been suggested as a powerful and non-invasive treatment for a range of psychiatric, neurological and neurodevelopmental conditions. Yet, the therapeutic interventions were, and still are, often not hypothesis-driven as broader theories remain scarce and underlying neurophysiological mechanisms are often vague. We aim to critically review the literature on vestibular stimulation as a form of therapy in various selected disorders and present its successes, expectations, and drawbacks from a historical perspective. AbstractAlthough the discovery and understanding of the function of the vestibular system date back only to the

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Minor adverse effects of galvanic vestibular stimulation in persons with stroke and healthy individuals

Abstract: Sub-sensory GVS and GVS with 1.5 mA induce very few and mild adverse effects in healthy and persons with stroke and are safe when safety guidelines are followed.

Cited by 83 publications

References 40 publications

Effects of non-invasive brain stimulation on attention: Current debates, cognitive studies and novel clinical applications

Effects of non-invasive brain stimulation on attention: Current debates, cognitive studies and novel clinical applications

Galvanic Vestibular Stimulation Improves Arm Position Sense in Spatial Neglect

The Moving History of Vestibular Stimulation as a Therapeutic Intervention

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