Minor Salivary Gland Basal Cell Adenocarcinoma

Cuthbertson, David; Hicks, John; Green, Linda; Parke, Robert B

doi:10.1001/jamaoto.2014.3344

Cited by 22 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Based on careful revision of serial pre-operative MRI, transient evidence of an intrasphenoidal cyst was noticed, placed on the TS route to the prolactinoma. As only pathological minor salivary glands are seen by radiological imaging [ 58 , 59 ], we finally concluded for residual inflammation in a submucosal SG following spontaneous reabsorption of the cyst. This pitfall should therefore be considered in the presence of SG acini contaminating surgical fragments obtained by TS, as it may open the possibility of a second TS approach.…”

Section: Discussionmentioning

confidence: 96%

Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review

Feola

Gianno

Angelis

et al. 2021

J Endocrinol Invest

View full text Add to dashboard Cite

Purpose Salivary gland (SG) tissue and derived neoplasms may occur in the sellar region. As the current literature is mostly limited to case reports, the puzzling case of an inflammatory SG removed by transsphenoidal surgery (TS) and mimicking a prolactinoma prompted us to perform the first systematic review of these unusual conditions. Methods A systematic literature search was conducted according to the PRISMA guidelines. Forty-four individual cases—non-neoplastic enlarged salivary glands (NNESG, n = 15), primary benign (n = 7) and malignant (n = 8) ectopic salivary tumours (ST) and sellar metastasis from eutopic primary ST (n = 14)—were suitable for the analysis of clinical, radiological and pathological characteristics. Therapeutic outcome was reviewed as a secondary endpoint. Results All cases were diagnosed after surgery. NNESG commonly affected young and/or female patients, typically leading to headaches and hyperprolactinemia and originating close to the neurohypophysis. Submucosal SG should be excluded before concluding to an intrasellar NNESG after TS. No gender or age predominance was found for primary ectopic ST, which present as large tumors, with histological phenotypes similar to common ST. Hypopituitarism and diabetes insipidus were more frequent in ST than in NNESG. NNESG and benign ectopic ST rarely recur. Malignant ectopic ST should be distinguished from secondary localizations of eutopic ST reaching the sella by contiguity or metastatic spread; both share a frequent unfavorable outcome. Conclusion Sellar neoplasms derived from SG are rare but misleading conditions and pituitary dysfunction is likely to be more common than currently reported. Appropriate pathological evaluation and multidisciplinary approach are required.

show abstract

Section: Discussionmentioning

confidence: 96%

Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review

Feola

Gianno

Angelis

et al. 2021

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…Since these cancers seldom metastasize to lymph nodes, neck dissection is not routinely recommended. However, reported local recurrence rates of basal cell carcinoma are high, and the mortality rate is low [8,9]. Here we report a rare and challenging case of carcinoma ex BCA with local recurrence within two years to raise the awareness of both surgeons and pathologists of such an unusual tumor disorder.…”

Section: Introductionmentioning

confidence: 82%

A Rare Case of Recurrent Carcinoma Ex Basal Cell Adenoma of the Parotid Gland

Alzahrani

2023

Cureus

View full text Add to dashboard Cite

Basal cell adenoma is encountered in the salivary glands, particularly the parotid gland; however, malignant transformation is rare, and recurrence is much rarer. We report the case of a 60-year-old man who had experienced a slow-growing mass in the parotid gland, which was suspected to be pleomorphic adenoma. Radiological and cytological examination suggested an atypical lesion in the left parotid. The final diagnosis reached on the excised specimen was that of a basal cell adenocarcinoma ex adenoma with close margins. The patient presented with a recurrence after two years. Routine histopathological examination with careful examination by the pathologist is essential for proper management of such rare malignant lesions, and recurrence is a possibility. A complete excision of the tumor with tumor-free margins from the beginning is suggested.

show abstract

“…Regional lymph node dissection is indicated only in cases involving cervical lymph nodes [ 3 , 4 , 15 – 17 ]. BCAC affecting the minor salivary glands are more infiltrative than lesions affecting the major salivary glands [ 18 ]. Several surgical approaches have been described, such as an infratemporal approach from the lateral aspect, an antereolateral approach and transpalatal, transmaxillary, and transcervical approaches from the inferior aspect [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Basal cell adenocarcinoma of the nasopharyngeal minor salivary glands: a case report and review of the literature

Jin

2018

BMC Cancer

View full text Add to dashboard Cite

BackgroundBasal cell adenocarcinomas (BCACs) arise from the minor salivary glands in the upper respiratory tract and are extremely rare. In this report, we present an unusual case of a 57-year-old male with BCAC that arose from the nasopharynx. To our knowledge, this is the first case report of nasopharyngeal BCAC.Case presentationIn August 2010, a 57-year-old Chinese male presented with epistaxis and decreased hearing for 1 month. He was diagnosed with BCAC of the solid type that arose from the nasopharynx. The patient received radiotherapy alone and exhibited a complete response. A follow-up at 72 months did not detect any evidence of disease recurrence or metastasis. A comprehensive literature review revealed only 7 previously reported cases of BCAC in the upper respiratory tract. Surgery is the first choice to treat BCAC but may impair maxillofacial function. Radiotherapy is reserved for inoperable cases.ConclusionsRadiotherapy can achieve good local control and preserve maxillofacial function; therefore, this treatment may be a suitable option for patients who are not good candidates for surgery.

show abstract

Minor Salivary Gland Basal Cell Adenocarcinoma

Cited by 22 publications

References 36 publications

Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review

Salivary gland tissues and derived primary and metastatic neoplasms: unusual pitfalls in the work-up of sellar lesions. A systematic review

A Rare Case of Recurrent Carcinoma Ex Basal Cell Adenoma of the Parotid Gland

Basal cell adenocarcinoma of the nasopharyngeal minor salivary glands: a case report and review of the literature

Contact Info

Product

Resources

About