Minor Secondary Metabolic Products from the Stem Bark of<i>Plumeria rubra</i>Linn. Displaying Antimicrobial Activities

Kuigoua, Guy Merlin; Kouam, Siméon F.; Ngadjui, Bonaventure T.; Schulz, Barbara; Green, Ivan R.; Choudhary, M. Iqbal; Krohn, Karsten

doi:10.1055/s-0029-1240611

Cited by 43 publications

(24 citation statements)

References 24 publications

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“…The plant has been investigated for antibacterial (Hamburger et al, 1991;Egwaikhide et al, 2007Egwaikhide et al, , 2009Kuigoua et al, 2010;Baghel et al, 2010;Dey et al, 2011), antifungal (Kuigoua et al, 2010;Souza et al, 2011;Gaitan et al, 2011), antimicrobial (Mahady, 2002), antialgal (Kuigoua et al, 2010), larvicidal (Ramos et al, 2009;Patil et al, 2012), molluscicidal (Hamburger et al, 1991), piscicidal (Joshi and Joshi, 2006), nematicidal (Joymati, 2010), antioxidative and free radical scavenging activities (Ruiz-Teran et al, 2008), hypolipidemic (Merina et al, 2010), proteolytic (De Freitas et al, 2010), cytotoxic (Kardono et al, 1990;Hamburger et al, 1991;Rekha and Jayakar, 2011), abortifacient (Dabhadkar and Zade, 2012) and anti HIV (Tan et al, 1991) properties. The biocatalytic activity in terms of lipase activity in hydrolysis and acyl transfer reactions of latex was compared with that of babaco (Vasconcellea x Heilbornii Cv.)…”

Section: Pharmacologymentioning

confidence: 99%

“…Chavero and Roces (1988) Phytochemistry: Iridoids such as fulvoplumierin, allamcin, allamandin, plumericin, 15-demethylplumieride, plumieride, alpha-allamcidin, beta-allamcidin and 13-O-trans-pcoumaroylplumieride; 2,5-dimethoxy-p-benzoquinone and lignan liriodendrin were isolated from the bark of Indonesian P. rubra (Kardono et al, 1990). Furthermore, four new iridoids such as plumeridoids A, B and C and epiplumeridoid C and several known compounds like 1-(P-hydroxyphenyl) propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, P-E-coumaric acid, 2,6-dimethoxy-P-benzoquinone, scopoletin, cycloart-25-en-3 beta,24-diol, 2,4,6-trimethoxyaniline, ajunolic acid, ursolic acid, oleanolic acid, beta-amyrin acetate, betulinic acid, lupeol and its acetate, 2,3-dihydroxypropyl octacosanoate, glucoside of beta-sitosterol, stigmasterol and beta-sitosterol were reported from the plant species (Kuigoua et al, 2010). Cardiac glycosides were also found to be present (Radford et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

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Plumeria rubra L. (Apocynaceae): Ethnobotany, Phytochemistry and Pharmacology: A Mini Review

Dey¹,

Mukherjee²

2015

J. of Plant Sciences

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Plumeria rubra L. (Apocynaceae) is a deciduous ornamental tree species with fragrant flowers native to Mexico, Central America, Colombia and Venezuela but also cultivated in tropical and subtropical countries. The plant is known to possess biological activities viz., antibacterial, antifungal, antiviral, antialgal, larvicidal, molluscicidal, piscicidal, nematicidal, antioxidative and free radical scavenging, hypolipidemic, proteolytic, cytotoxic, abortifacient activities etc. A number of phyto-constituents are reported from the plant which signifies biological activities and diverse ethnomedicinal uses of this plant species. The present review deals with the literature involving ethnobotany, phytochemistry and pharmacology of the plant.Key words: Plumeria rubra, ethnobotany, phytochemistry, pharmacology, review INTRODUCTIONPlumeria rubra L. (Apocynaceae) commonly known as 'Frangipani' is an ornamental tree species bearing fragrant flowers. The plant is native to Mexico, Central America, Colombia and Venezuela but cultivated in tropical and subtropical countries. The plant is reportedly used in a number of traditional medicinal preparations throughout Asia and Latin America for diabetes, diarrhea, dysentery, intestinal worms, stomach-ache, toothache, earache, eye-cleaning, tongue cleaning, finger nail pain, wound healing, fractures, blisters, sores, subcutaneous mycosis, rabies, malaria, rheumatism, asthma, cancer, birth control, women complaints, lactation, pediatric care, ethnoveterinary (diarrhoea and dysentery and snakebite), piscicidal, offering to god and as ornamental and it is also utilized as part of folk ritual due to its aesthetic values. A number of preclinical pharmacological investigations were performed to elucidate its bioactivities such as antibacterial, antifungal, antiviral, antialgal, larvicidal, molluscicidal, piscicidal, nematicidal, antioxidative and free radical scavenging, hypolipidemic, proteolytic, anticancer, abortifacient properties. A number of phytochemicals have been isolated from the plant, a few of which were correlated with its bioactivity. A systematic compilation on ethnobotanical, phytochemical and pharmacological aspects has been given in this paper.

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Section: Pharmacologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plumeria rubra L. (Apocynaceae): Ethnobotany, Phytochemistry and Pharmacology: A Mini Review

Dey¹,

Mukherjee²

2015

J. of Plant Sciences

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“…14 Generally, possess significant anti-inflammatory, analgesic, antibacterial, antifungal, antitumor activities, antioxidant, antiviral, anxiolytic and purgative activities. 13,[15][16][17][18][19] The iridoid plumieride has been isolate from several genus like Allamanda, Himatanthus, Plantago and Plumeria in different yields. [20][21][22][23][24][25] Plumieride shows antidermatophytic, antifungal, plant growth inhibitory potential and in vitro cytotoxicity against radiationinduced fibrosarcoma (RIF) tumor cells.…”

Section: Introductionmentioning

confidence: 99%

DEVELOPMENT AND OPTIMIZATION OF A MICROWAVE-ASSISTED EXTRACTION OF PLUMIERIDE FROM Allamanda cathartica L. FLOWERS

Bonomini¹,

Góes²,

Machado³

et al. 2017

Quim. Nova

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A simple and efficient microwave-assisted extraction process has been developed in order to extract plumieride from Allamanda cathartica flowers. The extracts have been obtained through microwave-assisted extraction (MAE) process with ethanol and ethyl acetate at different time, power and temperatures. Static maceration at room temperature with ethanol and ethyl acetate was obtained in order to compare the efficiency of extraction. HPLC method was validated to quantify plumieride in the extracts. The analyzed parameters: linearity (R 2 = 0.999), precision (CV 3.3%), recovery (98%), specificity (97%), limit of detection (1 µg mL -1), and limit of quantification (2 µg mL -1 ) were satisfactory. The yield of plumieride reached 43% in the extracts under the optimal MAE conditions (10 min, 300W). Plumieride recoveries by conventional extraction method were 12% with ethanol and 22% with ethyl acetate. Time and power parameters on plumieride extraction yield was determined by applying a factorial design and surface plots. Ethanol was the best extractor solvent and it was possible to obtain high contents (52 mg g -1 of dry flowers) at optimized conditions. It can be concluded that MAE process has actual advantages over the conventional extraction method in terms of shorter time and higher efficiency to recover plumieride from A. cathartica flowers.

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“…10 It has been reported that distinct parts of Fringpiani have diverse biological properties. Pod has abortifacient, 11 hepatoprotective 12 effects; bark is antinociceptive and anti-inflammatory. 13 Leaves are found to have antiulcer activity, 14 whereas flowers have profound antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostic Standardization and Chromatographic Fingerprint Analysis on Triterpenoids Constituents of the Medicinally Important Plant Plumeria rubra f. rubra by HPTLC technique

Srivastava¹,

Gupta²,

Singh³

et al. 2017

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Introduction: Plumeria rubra f. rubra commonly known as Lal Gulachin has wide horizon of medicinal possessions. Plant is found in India and in its tropical regions. Though the plant and its extracts have been indigenously valued as folklore medicine diversely in India, yet literature lacks somewhere in reverse pharmacognostical approach of this plant which reflects that plant have not been evidently explored therapeutically. There are several forms of Plumeria rubra among which P. rubra f. rubra is much appraised in India than its other forms. Method: In Present study the anticipated potential of this plant has been validated by laying down its pharmacognostical standards along with measurement of its active therapeutic constituent Ursolic acid and Lupeol via. HPTLC, information from organized search of published literature remarks that Ursolic acid and lupeol is ubiquitous to this plant. Results: Microscopic features revealed the presence of paracytic type of stomata, crescent bicollateral vascular bundle, calcium oxalate crystal and clothing trichomes in leaves whereas bark showed the presence of distinct periderm with cork and phellogen, sclereids, bast tissue with parenchymatous cells. Methanolic extract of both parts of plant was subjected to HPTLC. In HPTLC studies the Ursolic acid content in leaves was found to be 0.96% whereas in bark was detected as 0.051%, lupeol content in leaves and stem was found to be 0.014% and 0.018%. Conclusion: The data generated could be significantly used as reference for the standardization and quality control of Plumeria. rubra f. rubra, as no such work has been reported yet.

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Minor Secondary Metabolic Products from the Stem Bark ofPlumeria rubraLinn. Displaying Antimicrobial Activities

Cited by 43 publications

References 24 publications

Plumeria rubra L. (Apocynaceae): Ethnobotany, Phytochemistry and Pharmacology: A Mini Review

Plumeria rubra L. (Apocynaceae): Ethnobotany, Phytochemistry and Pharmacology: A Mini Review

DEVELOPMENT AND OPTIMIZATION OF A MICROWAVE-ASSISTED EXTRACTION OF PLUMIERIDE FROM Allamanda cathartica L. FLOWERS

Pharmacognostic Standardization and Chromatographic Fingerprint Analysis on Triterpenoids Constituents of the Medicinally Important Plant Plumeria rubra f. rubra by HPTLC technique

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