Minor stroke in a Takotsubo-like syndrome: A rare clinical presentation due to transient left ventricular thrombus

Gregorio, Cesare de; Cento, D; Bella, Gianluca Di; Coglitore, Sebastiano

doi:10.1016/j.ijcard.2007.11.104

Cited by 18 publications

(12 citation statements)

References 12 publications

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“…No serious arrhythmic disorders were reported in this case series, with the exception of some patients showing sinus bradycardia [22] or tachycardia [24].…”

Section: Electrocardiographic Findingsmentioning

confidence: 61%

Cardioembolic outcomes in stress-related cardiomyopathy complicated by ventricular thrombus: A systematic review of 26 clinical studies

Gregorio

2010

International Journal of Cardiology

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“…No serious arrhythmic disorders were reported in this case series, with the exception of some patients showing sinus bradycardia [22] or tachycardia [24].…”

Section: Electrocardiographic Findingsmentioning

confidence: 61%

Cardioembolic outcomes in stress-related cardiomyopathy complicated by ventricular thrombus: A systematic review of 26 clinical studies

Gregorio

2010

International Journal of Cardiology

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“…No arrhythmic disorders were reported in these studies, except for sinus bradycardia [17]. Electrocardiography did not allow distinguishing between patients with or without cardioembolic complications.…”

Section: Electrocardiographic Findingsmentioning

confidence: 75%

“…In three cases (20%), cardioembolic stroke was the main clinical presentation [9,17]. Late renal embolization (3 days after the clinical presentation of Takotsubo syndrome) was reported in another patient [11], and leg ischemia in the last one [19].…”

Section: Cardioembolic Events and Treatment Of Ventricular Thrombosismentioning

confidence: 95%

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Left ventricular thrombus formation and cardioembolic complications in patients with Takotsubo-like syndrome: A systematic review

Gregorio¹,

Grimaldi²,

Lentini³

2008

International Journal of Cardiology

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140

109

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“…A recent case repot describes a 88 years old female with biventricular TCM complicated by biventricular thrombosis [23]. A thrombus attached to the septo-apical wall [24], a thrombus attached to the apical inferior wall by a thin stalk [25], a thrombus attached to an akinetic segment of the anterior and anteroseptal wall, a mobile thrombus adjacent to the anterolateral papillary muscle [8], a mobile thrombus adjacent to the posteromedial papillary muscle [8], two mobile thrombi in the left ventricular apex [8] and multiple thrombotic masses in the left ventricular apex [26] were also described.…”

Section: Discussionmentioning

confidence: 99%

Takotsubo cardiomyopathy complicated with apical thrombus formation on first day of the illness: a case report and literature review

Herath

Pahalagamage

Lindsay

et al. 2017

BMC Cardiovasc Disord

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BackgroundTakotsubo cardiomyopathy is characterized by transient systolic dysfunction of the apical and mid segments of the left ventricle in the absence of obstructive coronary artery disease. Intraventricular thrombus formation is a rare complication of Takotsubo cardiomyopathy and current data almost exclusively consists of isolated case reports and a few case series. Here we describe a case of Takotsubo cardiomyopathy with formation of an apical thrombus within 24 h of symptom onset, which has been reported in the literature only once previously, to the best of our knowledge. We have reviewed the available literature that may aid clinicians in their approach to the condition, since no published guidelines are available.Case presentationA 68-year-old Sri Lankan female presented to a local hospital with chest pain. Electrocardiogram (ECG) showed ST elevation, and antiplatelets, intravenous streptokinase and a high dose statin were administered. Despite this ST elevation persisted; however the coronary angiogram was negative for obstructive coronary artery disease. Echocardiogram revealed hypokinesia of the mid and apical segments of the left ventricle with typical apical ballooning and a sizable apical thrombus. She had recently had a viral infection and was also emotionally distressed as her sister was recently diagnosed with a terminal cancer. A diagnosis of Takotsubo cardiomyopathy was made and anticoagulation was started with heparin and warfarin. The follow up echocardiogram performed 1 week later revealed a small persistent thrombus, which had completely resolved at 3 weeks.ConclusionThough severe systolic dysfunction is observed in almost all the patients with Takotsubo cardiomyopathy, intraventricular thrombus formation on the first day of the illness is rare. The possibility of underdiagnosis of thrombus can be prevented by early echocardiogram in Takotsubo cardiomyopathy. The majority of reports found in the literature review were of cases that had formed an intraventriclar thrombus within the first 2 weeks, emphasizing the importance of follow up echocardiography at least 2 weeks later. The management of a left ventricular thrombus in Takotsubo cardiomyopathy is controversial and in most cases warfarin and heparin were used for a short duration.Electronic supplementary materialThe online version of this article (doi:10.1186/s12872-017-0616-0) contains supplementary material, which is available to authorized users.

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Minor stroke in a Takotsubo-like syndrome: A rare clinical presentation due to transient left ventricular thrombus

Cited by 18 publications

References 12 publications

Cardioembolic outcomes in stress-related cardiomyopathy complicated by ventricular thrombus: A systematic review of 26 clinical studies

Cardioembolic outcomes in stress-related cardiomyopathy complicated by ventricular thrombus: A systematic review of 26 clinical studies

Left ventricular thrombus formation and cardioembolic complications in patients with Takotsubo-like syndrome: A systematic review

Takotsubo cardiomyopathy complicated with apical thrombus formation on first day of the illness: a case report and literature review

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