Minoxidil-Associated Exudative Pleural Effusion

Siddiqui, Atif; Ansari, Mohammed Ghouse Ahmed; Shakil, Jawairia; Chemitiganti, Rama

doi:10.1097/smj.0b013e3181be3415

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…[2][3][4] In these cases, there were no recurrent effusions following cessation of the drug. In any patient on dialysis and minoxidil, identification of a pleural or pericardial effusion unresponsive to ultrafiltration should prompt suspicion of this complication.…”

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confidence: 79%

Minoxidil-Associated Pleuropericardial Effusion

Brondfield

Benowitz

2016

J GEN INTERN MED

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confidence: 79%

Minoxidil-Associated Pleuropericardial Effusion

Brondfield

Benowitz

2016

J GEN INTERN MED

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“…However, it carries a boxed warning of a rare finding: medication-induced pericardial effusion that can progress to tamponade [3]. There have been case reports of minoxidil used in dialysis and normal renal patients and causing pericardial effusion, but only three cases of pleuropericardial effusion have been published and reported to date [4][5][6]. This case report discusses minoxidil-induced anasarca and pleuropericardial effusion.…”

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confidence: 99%

Atypical Case of Minoxidil-Induced Generalized Anasarca and Pleuropericardial Effusion

Gbadamosi¹,

Melvin²,

López³

2021

Cureus

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Minoxidil is an antihypertensive medication used to control blood pressure that is resistant to three or more antihypertensive medications including diuretics. There have only been a few reported cases of minoxidilinduced pleuropericardial effusion with anasarca. Here, we discuss the case of a 70-year-old male with a history of uncontrolled hypertension who presented to the hospital with swelling of the extremities. He was on minoxidil 10 mg twice a day and complained of generalized body swelling and extremity pain with symptoms of dyspnea on exertion, paroxysmal nocturnal dyspnea, weight gain, abdominal distention, and intermittent, throbbing extremity pain (8/10). The patient denied a history of cardiac disease, pulmonary embolism, deep vein thrombosis, and malignancy. His vitals were stable with a blood pressure of 152/67 mmHg. The physical examination findings were significant for positive jugular vein pressure, bilateral crackles at the lung bases with abdominal distention, fluid thrill, and flank edema. The extremities showed pitting edema in the upper and lower extremities that were tender to palpation. Laboratory results were only significant for uremia and elevated brain natriuretic peptide. Electrocardiography, echocardiography, and CT of the chest and abdomen exhibited findings consistent with pericardial effusion, pleural effusion, abdominal ascites, and anasarca in the soft tissues of the axilla and chest wall. After discontinuation of minoxidil and starting intravenous diuretics, the patient showed clinical improvement. This case report reviews and explains that minoxidil-induced anasarca should be considered as a differential diagnosis in patients taking minoxidil as knowledge of this rare finding may lead to early diagnosis and management.

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Current awareness: Pharmacoepidemiology and drug safety

2010

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 23 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Antidiabetic Agents; 21 Contrast Agents; 22 Bone Conservation Agents; 23 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Minoxidil-Associated Exudative Pleural Effusion

Cited by 12 publications

References 4 publications

Minoxidil-Associated Pleuropericardial Effusion

Minoxidil-Associated Pleuropericardial Effusion

Atypical Case of Minoxidil-Induced Generalized Anasarca and Pleuropericardial Effusion

Current awareness: Pharmacoepidemiology and drug safety

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