Minoxidil-associated pericardial effusion and impending tamponade

Lew, Michelle J.; Amato, Jordan

doi:10.1097/01.jaa.0000944608.70893.b3

Jaapa

2023

DOI: 10.1097/01.jaa.0000944608.70893.b3

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Minoxidil-associated pericardial effusion and impending tamponade

Michelle J. Lew,

Jordan Amato

Abstract: A patient with a large pericardial effusion and impending tamponade exhibited clinical improvement with urgent pericardiocentesis. Further workup ruled minoxidil to be the likely cause of the effusion. After discontinuation of minoxidil, the effusion did not recur.

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2024

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Cited by 3 publications

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Evaluation of the Safety and Effectiveness of Oral Minoxidil in Children: A Systematic Review

Williams,

Olukoga,

Tosti

2024

Dermatol Ther (Heidelb)

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The minimal adverse-effect profile and positive clinical response of low-dose oral minoxidil (LDOM) have recently caused the drug to gain popularity for the treatment of hair disorders in adults. However, in the pediatric population, hesitancy still surrounds the use of oral minoxidil given the wide profile of potential side effects the drug offers. This review aims to characterize the safety and use of oral minoxidil in children for the treatment of all disorders to equip physicians with ample knowledge when prescribing oral minoxidil in the pediatric population. A total of 41 studies (19 case reports, 10 cohort studies, 7 retrospective chart reviews, and 5 case series) that reported data on 442 pediatric patients for whom oral minoxidil was used for treatment were included. Conditions for which treatment with minoxidil was described were hair disorders (83.9%, 371/442) and hypertension (11.3%, 50/442); accidental usage (4.8%, 21/442) was also noted in the literature and included in this review. This review is broken down by dosage and describes the safety and efficacy of oral minoxidil in pediatric patients aged 0 to 18 years old for the treatment of hair disorders. This review found that LDOM may represent a safe option for the treatment of hair disorders in children. This study also suggests moderate and high doses of oral minoxidil may not be safe for use in children. Additional studies are needed to further understand this drug’s efficacy and safety in children.

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Evaluation of the Safety and Effectiveness of Oral Minoxidil in Children: A Systematic Review

Williams,

Olukoga,

Tosti

2024

Dermatol Ther (Heidelb)

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Minoxidil-Related Pericarditis

Abdulhai,

Parizher,

Zmaili

et al. 2024

JACC: Case Reports

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The Role of Patient‐ and Drug‐Related Factors in Oral Minoxidil and Pericardial Effusion: Analyses of Data From the United States Food and Drug Administration Adverse Event Reporting System

Gupta,

Bamimore,

Haber

et al. 2024

J of Cosmetic Dermatology

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BackgroundWhile oral minoxidil (OM) has been associated with pericardial effusion (PE), its etiology is presently inconclusive.AimsWe characterized patient‐ and drug‐related factors across reports from the United States Food and Drug Administration Adverse Event Reporting System (FAERS) for PE and OM.MethodsOur observation period spanned 18.5 years. Parametric and non‐parametric analyses were used; we stratified our findings according to two groups of adverse events (AEs), namely, PE and all other AEs.ResultsAcross reports of OM (n = 2747), positive dechallenge (complete resolution or subsiding of AE upon discontinuation of OM) was significantly more likely to occur for PE than for all other AEs (p < 0.05). Furthermore, OM was significantly more likely to play a primary role in PE compared to all other AEs (p < 0.05). The proportion of men was significantly higher in OM reports of PE than in OM reports of all other AEs (p < 0.05). We also identified six reports of PE and topical minoxidil.ConclusionsThough findings from spontaneously reported data never prove causality, our findings on dechallenge and purported role may suggest one. There were no reports of PE at a dose < 2.5 mg/day, 2/35 reports at 2.5 mg/day, and 8/35 reports at 5 mg/day. Overall, the results of statistical analyses support that the relationship between OM and PE is dose independent. Caution should also be taken when applying minoxidil topically because of reports of PE associated with this route of administration.

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Minoxidil-associated pericardial effusion and impending tamponade

Abstract: A patient with a large pericardial effusion and impending tamponade exhibited clinical improvement with urgent pericardiocentesis. Further workup ruled minoxidil to be the likely cause of the effusion. After discontinuation of minoxidil, the effusion did not recur.

Cited by 3 publications

References 17 publications

Evaluation of the Safety and Effectiveness of Oral Minoxidil in Children: A Systematic Review

Evaluation of the Safety and Effectiveness of Oral Minoxidil in Children: A Systematic Review

Minoxidil-Related Pericarditis

The Role of Patient‐ and Drug‐Related Factors in Oral Minoxidil and Pericardial Effusion: Analyses of Data From the United States Food and Drug Administration Adverse Event Reporting System

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