Mint oil (<i>Mentha spicata</i> Linn.) offers behavioral radioprotection: a radiation‐induced conditioned taste aversion study

Haksar, Anupum; Sharma, Ashok; Chawla, Raman; Kumar, Raj; Lahiri, Sitanshu S.; Islam, Fakhrul; Arora, Mohit; Sharma, Rakesh; Tripathi, RP; Arora, Rajesh

doi:10.1002/ptr.2604

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…Mint oil blocked the saccharin avoidance response within 5 post-treatment observational days and demonstrated that mint oil may be of use in preventing the radiation-induced behavioral changes. [28] …”

Section: Mint Mitigates Radiation-induced Behavioral Perturbations Inmentioning

confidence: 97%

“…Due to these reasons the conditioned taste aversion has been proposed as a standard procedure and a reliable paradigm for evaluating behavioral alterations induced by radiation or other environmental agents/toxins. [27] Haksar et al, [28] have observed that the oil from M. spicata mitigated the radiation-induced conditioned taste aversion in rats. Intraperitoneal administration of the oil before exposure to radiation offered significant radioprotection against conditioned taste aversion.…”

Section: Mint Mitigates Radiation-induced Behavioral Perturbations Inmentioning

confidence: 98%

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Radioprotective potential of mint: A brief review

Baliga

Rao

2010

J Can Res Ther

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Radiation is an important modality in cancer treatment and estimates are that between one third and one half of all patients will require ionizing irradiation therapy during some point in their clinical management. However, the radiation-induced damage to the normal tissues restricts the therapeutic doses of radiation that can be delivered to tumors and thereby limits the effectiveness of the treatment. The use of chemical compounds (radioprotectors) represents an obvious strategy to improve the therapeutic index in radiotherapy. However, most of the synthetic radioprotective compounds studied have shown inadequate clinical application owing to their inherent toxicity and high cost. These observations necessitated a search for alternative agents that are less toxic and highly effective. Studies in the recent past have shown that some medicinal plants possess radioprotective effects. Two species of the commonly used aromatic herb mint, Mentha piperita and M. arvensis protected mice against the γ-radiation-induced sickness and mortality. Detail investigations have also shown that the aqueous extract of M. piperita protected the vital radiosensitive organs: the testis, gastrointestinal and hemopoetic systems in mice. The radioprotective effects are possibly due to free radical scavenging, antioxidant, metal chelating, anti-inflammatory, antimutagenic, and enhancement of the DNA repair processes. This review for the first time summarizes the observations and elucidates the possible mechanisms responsible for the beneficial effects. The lacunae in the existing knowledge and directions for future research are also addressed.

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Section: Mint Mitigates Radiation-induced Behavioral Perturbations Inmentioning

confidence: 97%

Section: Mint Mitigates Radiation-induced Behavioral Perturbations Inmentioning

confidence: 98%

Radioprotective potential of mint: A brief review

Baliga

Rao

2010

J Can Res Ther

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“…was effective in mitigating radiation-induced conditioned taste aversion (CTA), a phenomenon understood to be controlled in rodents by the same pathways that control nausea and vomiting in humans. 45 It was observed that the intraperitoneal administration of mint oil (5, 7.5, 10, 12.5, and 15% v/v) 1 hour before exposure to 2 Gy of whole body irradiation showed significant decrease in CTA at all doses, when compared with the 2 Gy radiation control at all time points (1, 2, 3, 4, and 5 days post irradiation). However, the best effect was observed as follows 10% > 12.5% > 15% > 7.5% > 5%.…”

Section: Mint Oil In the Prevention Of Rinvmentioning

confidence: 91%

“…However, the best effect was observed as follows 10% > 12.5% > 15% > 7.5% > 5%. 45 Mechanistically, it is quite possible that the free radical scavenging and the antioxidant effects of mint may have contributed to the reduction in CTA. Studies have also shown that rotundifolone, an active constituent of mint oil, mimics the effects produced by calcium channel blockers, and thus can neutralize the injurious effects of biogenic amines such as histamines and 5-HT and also modulate vagal activity and reduce intestinal motility and contractility.…”

Section: Mint Oil In the Prevention Of Rinvmentioning

confidence: 99%

Medicinal Plants as Antiemetics in the Treatment of Cancer

et al. 2011

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Chemotherapy- and radiotherapy-induced nausea and vomiting are the most common, intractable and unpleasant side effects in patients undergoing treatment for cancer. 5-Hydroxytryptamine-3 (5-HT3) receptor antagonists plus dexamethasone have significantly improved the control of acute nausea and vomiting, but delayed nausea and vomiting remains a significant clinical problem. Combined neurokinin-1 receptor antagonists with 5-HT3 antagonists and steroids are observed to be better in the control of both acute and delayed emesis. However, the use of these antiemetics is observed to possess inherent side effects. The medicinal plants such as Scutellaria baicalensis, Korean red ginseng, American ginseng berry, Ganoderma lucidum, Zingiber officinale, grape seed extract, and the oil of Mentha spicata are reported to be effective in the treatment of nausea and vomiting mostly in preclinical studies. Of these, ginger has also been evaluated for its efficacy in humans and the results have been contradictory. The current review for the first time summarizes the results related to these properties. An attempt is also made to address the lacunae in these published studies and to emphasize aspects that need further investigations for these plants to be of use in clinics in the future.

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“…This herb is widely used in treatment of fever, vomiting, sinusitis and common cold (Güney et al, 2006). The anti-microbial, radioprotective, anti-oxidant, anti-tumoral and anti-inflammatory effects of spearmint have been reported (Lixandru et al, 2010;Haksar et al, 2009;Pearson et al, 2010;Hussain et al, 2010;Arumugam and Ramesh, 2009). Besides, the toxic effect of Mentha pulegium (another specious of Mentha genus) on some cancer cells has been shown (Shirazi et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Down regulation of matrix metalloproteinases by spearmint extract in Wehi-164 cells

Hajighasemi¹,

Hashemi²

2012

J. Med. Plants Res.

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Tumor invasion and metastasis are the main causes of cancer death. Matrix metalloproteinases (MMPs) are endopeptidases which degredate the extracellular matrix proteins. MMPs have an important role in tumor progression and metastasis. Fibrosarcoma has been recognized as a highly metastatic cancer which its current therapeutic methods have not been very successful. Medicinal plants are widely used in treatment of cancers. Spearmint is a herb with well known anti-tumor activities. In the present study, the effect of hydro extract of spearmint on MMP-2/9 activities in Wehi-164 fibrosarcoma cells has been evaluated in vitro. Wehi-164 cells were cultured in Roswell Park Memorial Institute (RPMI) medium with 10% fetal bovine serum (FBS). Then the cells at logarithmic growth phase were incubated with different concentrations of hydro extract of spearmint (0.1 to 10 mg/ml) in the presence or absence of phorbol myristate acetate (PMA) (25 ng/ml) for 24, 48 and 72 h. The MMP-2/MMP-9 activity in conditioned medium was evaluated by gelatin zymography. Spearmint aqueous extract significantly reduced the MMP-2 and PMA-induced MMP-9 activity in fibrosarcoma Wehi-164 cells dose dependently. The aqueous extract of spearmint showed inhibitory effect on MMP-2/MMP-9 activity in Wehi-164 fibrosarcoma cells. So, the anti-tumor effects of spearmint may be in part due to its inhibitory effects on MMP-2/MMP-9 activity. Evaluation of effective component (s) in the spearmint extract with anti-MMP activity and their mechanism of action could be useful in designing novel natural MMP inhibitors.

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Mint oil (Mentha spicata Linn.) offers behavioral radioprotection: a radiation‐induced conditioned taste aversion study

Cited by 12 publications

References 14 publications

Radioprotective potential of mint: A brief review

Radioprotective potential of mint: A brief review

Medicinal Plants as Antiemetics in the Treatment of Cancer

Down regulation of matrix metalloproteinases by spearmint extract in Wehi-164 cells

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