Minute lesions of alveolar damages in lungs of patients with stable chronic obstructive pulmonary disease

Emura, Iwao; Usuda, Hiroyuki; Satou, Kazuhiro

doi:10.21767/2572-5548.100028

Cited by 1 publication

(4 citation statements)

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“…SRA antigen is expressed only on macrophages . MLADs were detected in lungs of some patients with stable COPD, and large SRA + cells were observed in PB of Group B patients. SRA ‐ monocytes differentiated into SRA + cells after 5 days in culture with macrophage‐colony stimulating factor, and had differentiated into large sized macrophages by 10 days .…”

Section: Discussionmentioning

confidence: 94%

“…Small SRA þ cells were detected in all cases, but we could not distinguish small SRA þ cells from SRAmonocytes in smear preparations stained with Papanicolaou method. One to eighteen (Median [range], 4 [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] large SRA þ cells were observed in some of the smears from patients in Group B (Fig. 1).…”

Section: Sra þ Cells In the Systemic Circulationmentioning

confidence: 99%

“…8 We previously reported that minute lesions of alveolar damage (MLADs) were detected in lungs of patients with stable COPD. 9 MLADs were also observed in lungs of patients with stable idiopathic pulmonary fibrosis (IPF), and acute exacerbation of IPF restrictedly occurred in patients with MLADs. 10 Large scavenger receptor A-positive (SRA þ ) cells were detected in peripheral blood (PB) of patients with acute exacerbation of IPF, 11 and large SRA þ cells in PB might be a useful risk factor for acute exacerbation of IPF.…”

Section: Introductionmentioning

confidence: 99%

“…Chronic inflammatory changes with increased numbers of inflammatory cell types, and structural changes resulting from repeated injury and repair are found in the airway, lung parenchyma, and pulmonary vasculature of patients with COPD . We previously reported that minute lesions of alveolar damage (MLADs) were detected in lungs of patients with stable COPD . MLADs were also observed in lungs of patients with stable idiopathic pulmonary fibrosis (IPF), and acute exacerbation of IPF restrictedly occurred in patients with MLADs .…”

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confidence: 99%

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Appearance of large scavenger receptor A‐positive cells in peripheral blood: A potential risk factor for severe exacerbation of chronic obstructive pulmonary disease

Emura

Usuda

Satou

2019

Pathology International

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Fresh peripheral blood (PB) samples from 432 outpatients with stable chronic obstructive pulmonary disease (COPD) were examined. Patients were classified into Group A (large SRA+ cells were undetected) and Group B (large SRA+ cells were detected) and followed‐up for 1 year. Patients were further subdivided according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage. Cox proportional hazard model had shown that Gold, Group, home oxygen therapy (HOT), and treatment were significant predictors of severe exacerbation. Six of 353 patients in Group A and 29 of 79 in Group B developed severe exacerbation. The rates of severe exacerbation were significantly higher in Group B patients, GOLD stage 2 than Group A, GOLD stage 2; in Group B, GOLD stage 3 than Group A, GOLD stage 3; and in all of Group B compared with in all of Group A. The Kaplan‐Meier curves of Group B, GOLD stages 1–4, and of all of Group B showed significantly worse rates of severe exacerbation than those of Group A, Gold 1–4, and all of Group A, respectively. The appearance of large SRA+ cells in the PB of patients with stable COPD may represent a useful biomarker for severe COPD exacerbation.

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Section: Discussionmentioning

confidence: 94%