Minutes, days and years: molecular interactions among different scales of biological timing

Golombék, Diego A.; Bussi, Ivana L.; Agostino, Patricia V.

doi:10.1098/rstb.2012.0465

Cited by 65 publications

(47 citation statements)

References 141 publications

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“…For example, there is a link between circadian timing mechanisms and seasonal, photoperiodic driven changes in an organism’s physiology and behavior (Golombek et al, 2014). However, there is little evidence to date demonstrating a role of the circadian system in timing of developmental processes.…”

Section: Discussionmentioning

confidence: 99%

Clock Genes Control Cortical Critical Period Timing

Kobayashi

Hensch

2015

Neuron

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Summary Circadian rhythms control a variety of physiological processes, but whether they may also time brain development remains largely unknown. Here, we show that circadian clock genes control the onset of critical period plasticity in the neocortex. Within visual cortex of Clock-deficient mice, the emergence of circadian gene expression was dampened, and the maturation of inhibitory parvalbumin (PV)-cell networks slowed. Loss of visual acuity in response to brief monocular deprivation was concomitantly delayed and rescued by direct enhancement of GABAergic transmission. Conditional deletion of Clock or Bmal1 only within PV-cells recapitulated the results of total Clock-deficient mice. Unique downstream gene sets controlling synaptic events and cellular homeostasis for proper maturation and maintenance were found to be regulated by CLOCK specifically within PV-cells. These data demonstrate a developmental role for circadian clock genes outside the suprachiasmatic nucleus, which may contribute mis-timed brain plasticity in associated mental disorders.

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Section: Discussionmentioning

confidence: 99%

Clock Genes Control Cortical Critical Period Timing

Kobayashi

Hensch

2015

Neuron

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“…This range of values is consistent with the variation in sequence duration that Bhalla (2017) found for biological sequences in the hippocampus. While the mechanisms for temporal phenomena under the millisecond scale (inter-aural-scale, Carr and Konishi (1990)) and over the minute scale (circadian rhythms, Golombek et al (2014)) are already well understood, the nature and origin of temporal phenomena at the intermediate time scales is still a matter of debate (Paton and Buonomano, 2018). We believe our work contributes to this debate by offering an intrinsic model of time (Ivry and Schlerf, 2008) capable of both, using the taxonomy of Paton and Buonomano (2018), the production and reproduction of temporal patterns within the discussed range.…”

Section: Control Of the Temporal Structure Of The Sequencementioning

confidence: 99%

Probabilistic associative learning suffices for learning the temporal structure of multiple sequences

Martínez

Lansner

Herman

2019

Preprint

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Many brain phenomena both at the cognitive and behavior level exhibit remarkable sequential characteristics. While the mechanisms behind the sequential nature of the underlying brain activity are likely multifarious and multi-scale, in this work we attempt to characterize to what degree some of this properties can be explained as a consequence of simple associative learning. To this end, we employ a parsimonious firing-rate attractor network equipped with the Hebbian-like Bayesian Confidence Propagating Neural Network (BCPNN) learning rule relying on synaptic traces with asymmetric temporal characteristics. The proposed network model is able to encode and reproduce temporal aspects of the input, and offers internal control of the recall dynamics by gain modulation. We provide an analytical characterisation of the relationship between the structure of the weight matrix, the dynamical network parameters and the temporal aspects of sequence recall. We also present a computational study of the performance of the system under the effects of noise for an extensive region of the parameter space. Finally, we show how the inclusion of modularity in our network structure facilitates the learning and recall of multiple overlapping sequences even in a noisy regime.

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“…Los componentes principales del circuito temporal de las células son los genes clock y bmal1, cuyos productos se dimerizan en el complejo CLOCK/BMAL1 y forman lo que se conoce como el brazo positivo del reloj (13,14). Este complejo funciona como activador de la transcripción, por medio de elementos E-box de los genes period y cryptocrome al principio de cada día (12).…”

Section: Fundamentos Moleculares Del Reloj Biológicounclassified

“…Este complejo funciona como activador de la transcripción, por medio de elementos E-box de los genes period y cryptocrome al principio de cada día (12). Las proteínas PER y CRY se acumulan durante el día y forman un complejo represor PER/CRY, el brazo negativo del reloj, que al principio de la noche inhibe la actividad de CLOCK/BMAL1 (13,14). Este circuito de activación e inhibición genéticas dura aproximadamente 24 horas, y es finalmente regulado por el resto de la maquinaria del reloj molecular, que incluye los receptores nucleares Rev-erbβ y Roaa (8,14).…”

Section: Fundamentos Moleculares Del Reloj Biológicounclassified

“…Las proteínas PER y CRY se acumulan durante el día y forman un complejo represor PER/CRY, el brazo negativo del reloj, que al principio de la noche inhibe la actividad de CLOCK/BMAL1 (13,14). Este circuito de activación e inhibición genéticas dura aproximadamente 24 horas, y es finalmente regulado por el resto de la maquinaria del reloj molecular, que incluye los receptores nucleares Rev-erbβ y Roaa (8,14). El mecanismo molecular fue elucidado originalmente en la mosca de la fruta y aunque las secuencias de los genes no son las mismas, el proceso es altamente conservado filogenéticamente con diferentes grados de complejidad en otras especies incluyendo a los humanos (15).…”

Section: Fundamentos Moleculares Del Reloj Biológicounclassified

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Los ritmos circadianos en cáncer y la cronoterapia

Molina-Rodríguez¹,

Álvarez²

2016

iatreia

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RESUMENLos ritmos circadianos, períodos fisiológicos de 24 horas aproximadamente, coordinan la actividad temporal de la mayoría, si no, de todos los seres vivos del planeta. Uno de los procesos más importantes del cuerpo, la proliferación celular, también está regulado por el reloj biológico cuya alteración puede tener repercusiones directas en el desarrollo del cáncer. El concepto de cronoterapia ha surgido a partir de la evidencia que tanto la proliferación de las células, como los mecanismos responsables de la farmacocinética y la farmacodinamia de los antineoplásicos ocurren a horas específicas del día. En esta revisión se presentan las generalidades del ciclo circadiano y su relación con el ciclo celular y el cáncer. Además, se expone evidencia del uso de la cronoterapia en pacientes con leucemia linfocítica aguda y en estudios clínicos de cáncer de colon, endometrio y ovario con asignación aleatoria. Se concluye que la hora de administración de la quimioterapia debe tener en cuenta los ritmos circadianos de los pacientes. Se enfatiza en la necesidad de hacer estudios clínicos enfocados en la quimioterapia cronomodulada, con el fin de aumentar la tolerancia y efectividad de los medicamentos con los protocolos existentes.

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Minutes, days and years: molecular interactions among different scales of biological timing

Cited by 65 publications

References 141 publications

Clock Genes Control Cortical Critical Period Timing

Clock Genes Control Cortical Critical Period Timing

Probabilistic associative learning suffices for learning the temporal structure of multiple sequences

Los ritmos circadianos en cáncer y la cronoterapia

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