The present study was applied to an immediate post-operative patient for uterine myomatosis hospitalized in the obstetrics and gynecological service. Uterine fibroids or leiomyomas are tumors formed by smooth muscles that grow on the wall of the uterus. They are non-malignant tumors common in women of reproductive age. The objective was to manage nursing care in a postoperative patient for uterine myomatosis. The study had a qualitative, single-case approach; The methodology applied was the nursing care process (PAE), which included a 41-year-old patient, in which each of its stages was applied, the assessment was carried out through the assessment guide with the eleven patterns Marjory Gordon's functional models, three altered patterns were prioritized: cognition and perception, coping and tolerance to stress, and sleep and rest; The diagnostic stage was developed based on taxonomy II of NANDA I, seven nursing diagnoses were identified, prioritizing 3 of them: (00132) Acute pain, (00146) Anxiety and (00198) Altered sleep pattern, according to the format SSPFR (signs and symptoms, problem and related factor/risk factor/associated); In planning, the individualized care plan was developed based on the NOC Taxonomy, NIC with expected results and selection of interventions; In the execution stage, nursing care was administered and the care plan was updated; and the evaluation was given by the difference in final and baseline scores respectively; In the evaluation, favorable results were obtained with change scores of + 2, +2 and + 1. In conclusion, the PAE was carried out on the patient, which made it possible to provide humanized care with warmth and quality to the patient.