Miopatías inflamatorias idiopáticas: una mirada actualizada al diagnóstico y el manejo

Acosta, Ignacio; Matamala, José Manuel; Jara, Paula; Pino, Francisca; Gallardo, Alejandra; Verdugo, Renato J.

doi:10.4067/s0034-98872019000300342

Cited by 13 publications

(16 citation statements)

References 63 publications

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“…Ningún paciente presentó anticuerpos tipo ENA. Teniendo en cuenta el número de pacientes incluidos en este estudio, se puede observar que la prevalencia global de anticuerpos antimiositis en nuestra serie fue similar a lo publicado en la literatura [30][31][32][33][34] , aunque difiere en el perfil de anticuerpos encontrados, ya que el anticuerpo más frecuente descrito en las series de pacientes con DM es el anti-Jo-1, el cual estuvo ausente en los pacientes incluidos en este trabajo. Un tercio de los pacientes tuvo DMCA, de ellos solo 2 presentaron algún AEM, lo cual refleja una baja frecuencia de estos en este subgrupo de pacientes, ya descrito en otras series 37 .…”

Section: Discussionunclassified

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Manifestaciones clínicas y anticuerpos asociados y específicos de miositis en 15 pacientes chilenos con dermatomiositis: serie clínica en un centro universitario

T.¹,

Burgos

Prieto-González

2020

Rev. méd. Chile

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Clinical manifestations and antibody profile in 15 patients with dermatomyositis Background: Certain associated and specific myositis antibodies are related to certain clinical phenotypes of dermatomyositis (DM), disease severity and the presence of cancer. Aim: To describe the clinical profile of Chilean patients with DM and their associated and specific myositis antibodies. Material and Methods: Review of medical records of 15 patients with DM aged 31 to 72 years. Their clinical characteristics, laboratory tests and complementary tests were reviewed. In serum samples from each patient the presence of 16 specific antibodies was analyzed by immunoblot technique (Myositis Profile Euroline Blot test kit). Results: Fourteen (93.3%) patients had skin manifestations, five (33.3%) had pulmonary involvement, two (13.3%) had an associated cancer and nine (60%) had specific antibodies associated with myositis. Conclusions: These patients with DM had a clinical profile similar to what has been described elsewhere. The profile of myositis specific antibodies was different from reports in other populations.

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Section: Discussionunclassified

“…El tratamiento recibido en prácticamente la totalidad de los pacientes fue la asociación de un glucocorticoide sistémico con un inmunosupresor, en consonancia con las recomendaciones publicadas y lo descrito en práctica clínica 33 .…”

Section: Discussionunclassified

Manifestaciones clínicas y anticuerpos asociados y específicos de miositis en 15 pacientes chilenos con dermatomiositis: serie clínica en un centro universitario

T.¹,

Burgos

Prieto-González

2020

Rev. méd. Chile

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“…Como alternativas para el uso de metotrexato se menciona azatioprina, mofetil micofenolato, tacrolimus, ciclosporina o ciclofosfamida, pero la evidencia de elección de uno sobre otro es limitada. Un dato importante para destacar en pacientes con miopatía anti HMGCR(+) es que el tratamiento con inmunoglobulinas IV ha dado muy buenos resultados en el control de la enfermedad refractaria, aún como monoterapia en aquellos pacientes que tienen contraindicación absoluta para el uso de esteroides, siempre por datos extraídos de pequeñas series de casos 13 .…”

Section: Infecciosasunclassified

Autoimmune necrotizing myositis. Presentation of a clinical case

Plou¹,

Gaona²,

Caputo³

2021

Rev. Argent. Reumatol.

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Inflammatory myopathies (IM) or myositis are a heterogeneous group of muscle diseases of rare occurrence. Such diseases are characterized by inflammation of the different components of muscle tissue, which can occur either in isolation or, more commonly, as part of a systemic disorder. Immune-mediated necrotizing myopathies (IMNM) are a type of autoimmune myopathy characterized by proximal muscle weakness, myofiber necrosis with minimal inflammatory cell infiltrate on muscle biopsy and infrequent extramuscular involvement. Even though there are clinical and histopathological similarities. The spectrum of inflammatory myopathies is considerably variable. Therefore, the performance of complementary studies is essential for the proper identification of the IM subtype to contribute accurately on treatment so determine the better prognosis). The present article shows the case of a young 29 years old, with no personal and family history background of autoimmune disease and no relevant pathological back-ground. The patient consulted the medical ward of the Institution with pain, functional impairment of upper and lower extremities, muscle weakness mainly located in the pectoral girdle area and, although to a lesser degree, in the pelvic girdle area. It was also associated with asthenia, tendency to drowsiness and hyporeactivity.

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“…Dermatomyositis (DM) is a rare autoimmune disease. It is related to various amounts of systemic involvement, such as muscle, lung and other organs (1), characterised by proximal muscle weakness, elevation of muscle enzymes, myopathic changes on electromyography (EMG) and muscle pathological damage. Clinically amyopathic DM (CADM) is a combination of hypomyopathic DM (HDM) and amyopathic DM (ADM), with a characteristic skinpredominant lesions (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Nomogram to predict dermatomyositis prognosis: a population-based study of 457 cases

Wang

et al. 2022

Clinical and Experimental Rheumatology

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ObjectiveDermatomyositis (DM) is a systemic autoimmune disease, which typically affects the striated muscle with a variable involvement of the skin and other organs. Clinically amyopathic DM (CADM) is a combination of hypomyopathic DM (HDM) and amyopathic DM (ADM), with a characteristic of skin-predominant lesions. To date, large-scale studies on the prognostic factors of DM/CADM have been limited. The aim of this study is to evaluate the prognostic values of clinical manifestations in DM/CADM and to develop a prognostic nomogram for DM/CADM. Methods A development cohort (n =239), an internal validation cohort (n=128) and an external validation cohort (n=90) were included in this study. Overall survival (OS) was estimated by the Kaplan-Meier method. Univariate and multivariate Cox proportional hazards regression analyses were performed. Cox proportional hazards model and forward stepwise selection with the Akaike information criterion were used for multivariate analysis of prognostic factors. The concordance index(C-index) and calibration curve were calculated to evaluate the predictive accuracy of the proposed nomogram. Results Rapidly progressive interstitial lung disease (RP-ILD) and erythrocyte sedimentation rate (ESR) were identified as risk independent prognostic factors, with antinuclear antibodies (ANA) was identified as protective independent prognosticfactors, for DM/CADM. A prognostic nomogram was formulated based on these three predictors. The C-index of the proposed nomogram in the development cohort was 0.874 (95%CI, 0.819-0.929). The predictive accuracy of the proposed nomogram was further validated in the internal validation cohort, with a C-index of 0.799 (95%CI,. Furthermore, the C-index was 0.864 (95%CI, 0.699-1.000) in the external validation cohort, indicating a good calibration ability. This proposed nomogram showed a promising predictive accuracy on the prognosis of DM/CADM. ConclusionRP-ILD, ANA and ESR are prognostic factors for DM/CADM. The proposed nomogram based on these three factors could accurately predict the 10-year OS probabilities of patients with DM/CADM.

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Miopatías inflamatorias idiopáticas: una mirada actualizada al diagnóstico y el manejo

Cited by 13 publications

References 63 publications

Manifestaciones clínicas y anticuerpos asociados y específicos de miositis en 15 pacientes chilenos con dermatomiositis: serie clínica en un centro universitario

Manifestaciones clínicas y anticuerpos asociados y específicos de miositis en 15 pacientes chilenos con dermatomiositis: serie clínica en un centro universitario

Autoimmune necrotizing myositis. Presentation of a clinical case

Nomogram to predict dermatomyositis prognosis: a population-based study of 457 cases

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