miR-1-3p Inhibits Osteosarcoma Cell Proliferation and Cell Cycle Progression While Promoting Cell Apoptosis by Targeting CDK14 to Inactivate Wnt/Beta-Catenin Signaling

Zhang, Guangheng; Guan, Qingyu; Zhao, Yingsong; Wang, Siyuan; Li, Hewei

doi:10.1007/s12033-023-00811-1

Cited by 2 publications

(1 citation statement)

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“…miR-1-3p is lowly expressed in OS tissues and cells. Overexpression of miR-1-3p is able to inactivate the Wnt/β-catenin pathway by targeting cyclin-dependent kinase 14 (CDK14), thereby inhibiting cell proliferation and cell cycle progression while promoting apoptosis [ 137 ]. Cell cycle-dependent kinases (CDKs) are a class of key regulatory enzymes that drive cell cycle transitions and are considered to be critical targets for regulating cancer progression [ 138 – 140 ].…”

Section: Role Of Mir-1-3p In Tumor Occurrence and Developmentmentioning

confidence: 99%

The important role of miR-1-3p in cancers

Dai,

Li,

et al. 2023

J Transl Med

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Cancer is a malignant tumor that seriously threatens human life and health. At present, the main treatment methods include surgical resection, chemotherapy, radiotherapy, and immunotherapy. However, the mechanism of tumor occurrence and development is complex, and it produces resistance to some traditional treatment methods, leading to treatment failure and a high mortality rate for patients. Therefore, exploring the molecular mechanisms of tumor occurrence, development, and drug resistance is a very important task. MiRNAs are a type of non-coding small RNA that regulate a series of biological effects by binding to the 3′-UTR of the target mRNA, degrading the mRNA, or inhibiting its translation. MiR-1-3p is an important member of them, which is abnormally expressed in various tumors and closely related to the occurrence and development of tumors. This article introduces miR-1-3p from multiple aspects, including its production and regulation, role in tumor occurrence and development, clinical significance, role in drug resistance, and approaches for targeting miR-1-3p. Intended to provide readers with a comprehensive understanding of the important role of miR-1-3p in tumors. Graphical Abstract

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Section: Role Of Mir-1-3p In Tumor Occurrence and Developmentmentioning

confidence: 99%