2024
DOI: 10.20944/preprints202403.0693.v1
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miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region

Carlos García-Padilla,
Estefanía Lozano-Velasco,
Virginio García-López
et al.

Abstract: A large diversity of epigenetic factors, such as microRNAs and histones modifications, are known to be capable of regulating gene expression without altering DNA sequence itself. In particular, miR-1 is considered the first essential microRNA in cardiac development. In this study, miR-1 potential role in early cardiac chamber differentiation is analyzed through specific signaling pathways. For this, we performed in chick embryos functional experiments by means of miR-1 microinjections into the posterior cardia… Show more

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