miR-1, miR-21, and galectin-3 in hypertensive patients with symptomatic heart failure and left ventricular hypertrophy

Tomaniak, Mariusz; Sygitowicz, Grażyna; Błaszczyk, Olga; Kołtowski, Łukasz; Puchta, Dominika; Malesa, Karolina; Kochanowski, Janusz; Sitkiewicz, Dariusz; Filipiak‬, Krzysztof J.

doi:10.5603/kp.2018.0117

Cited by 15 publications

(13 citation statements)

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“…Furthermore, according to the results of the ROC analysis, miR-21 might be a good biomarker to distinguish HF + DM from DM. Contrary to our results, Tomaniak et al [39] found significant downregulation of miR-21 associated with the increase of LVEDD in symptomatic HF and that miR-21 was upregulated in fibroblasts with high glucose treatment and exerted its harmful effects [43]. Dai et al [50] demonstrated that miR-21 exerted its protective role directly in cardiac myocytes and encouraged further development of cardiac specific overexpression of miR-21 therapy toward cellular tropism.…”

Section: Discussioncontrasting

confidence: 99%

“…Restoration of miR-1 gene expression was a potential novel therapeutic strategy to reverse pressure-induced cardiac hypertrophy and prevent maladaptive cardiac remodeling. Tomaniak et al [39] found that in symptomatic HF patients with LVH, galectin-3 concentrations and miR-1 expressions were correlated with anatomic changes of the left ventricle. Karakikes et al [40] suggested that the restoration of miR-1 gene expression was a potential novel therapeutic strategy to reverse pressure-induced cardiac hypertrophy and prevent maladaptive cardiac remodeling.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic Patients

et al. 2019

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To investigate whether the circulating miR-1 (microRNA-1) and miR-21 expression might be used in the diagnosis of heart failure (HF) and silent coronary artery disease (SCAD) in asymptomatic type 2 diabetes mellitus (T2DM) patients and to explore the relationship of these miRs with N-terminal pro-brain natriuretic peptide (NT-proBNP) and galectin-3. One hundred thirty-five consecutive patients with T2DM and 45 matched control subjects were enrolled in the study. This study consisted of the following four groups: control group (mean age: 60.23 ± 6.27 years, female/male (F/M): 23/22); diabetic group (DM) (mean age: 61.50 ± 5.08, F/M: 23/22); DM + SCAD group (mean age: 61.61 ± 6.02, F/M: 20/25); and DM + acute HF group (mean age: 62.07 ± 5.26 years, F/M: 20/25). miR-1 was downregulated in the DM, CAD + DM and HF + DM groups by 0.54, 0.54, and 0.12 fold as compared with controls, respectively. The miR-1 levels were significantly lower in HF + DM than DM with 0.22 fold changes (p < 0.001); and in patients with CAD + DM group with 0.22 fold changes (p < 0.001). Similarly, miR-21 was overexpressed in patients with DM, CAD + DM, and HF + DM with 1.30, 1.79 and 2.21 fold changes as compared with controls, respectively. An interesting finding is that the miR-21 expression was significantly higher in the HF + DM group as compared with the CAD + DM group; miR-1 was negatively correlated with NT-proBNP (r = −0.891, p < 0.001) and galectin-3 (r = −0.886, p < 0.001) in the HF + DM group; and miR-21 showed a strongly positive correlation with (r = 0.734, p < 0.001) and galectin-3 (r = 0.764. p < 0.001) in the HF + DM group. These results suggest that the circulating decreased miR-1 and increased miR-21 expression are associated with NT-proBNP and galectin-3 levels in acute HF + DM. Especially the miR-21 expression might be useful in predicting the onset of acute HF in asymptomatic T2DM patients. The miR-21 expression is more valuable than the miR-1 expression in predicting cardiovascular events of acute HF and the combined analysis of miR-21 expression, galectin-3, and NT-proBNP can increase the predictive value of miR-21 expression.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic Patients

et al. 2019

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“…In combination with other researchers 'statistics on sample size, we selected more than 60 healthy samples and more than 60 cases of heart failure. Exhaustion samples were analyzed [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38]. As shown in Figure 1, the aim of the present study was to identify circulating miRNAs in human plasma as biomarkers for the diagnosis of heart failure and its related diseases, to assess the appropriate biomarkers for identifying key characteristics of miRNAs, and to analyze their performance.…”

Section: Introductionmentioning

confidence: 99%

Combined detection of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 for screening of early heart failure diseases

Ding

Wang

et al. 2020

Bioscience Reports

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The use of circulating microRNAs as biomarkers opens up new opportunities for the diagnosis of cardiovascular diseases because of their specific expression profiles. The aim of the present study was to identify circulating microRNAs in human plasma as potential biomarkers of heart failure and related diseases. We used real-time quantitative PCR to screen mi-croRNA in plasma samples from 62 normal controls and 62 heart failure samples. We found that circulating miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 expressed differently between healthy controls and heart failure patients. Plasma levels of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 were unaffected by hemolysis. Correlation analysis showed any two of these miRNAs possess a strong correlation, indicating a possibility of combined analysis. MiR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 could be combined in two or three or more combinations. The results suggest that miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 may be a new diagnostic biomarker for heart failure and related diseases.

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“…In a short announcement, Tomaniak and coauthors concluded that patients with decompensated systolic heart failure had a higher miR-21 expression, but it was comparable regardless of the left ventricular dimension. "The expression of miR-21 was comparable regardless of LV size" [57]. Studies of cardiac injuries and disturbances caused by aldosterone in rats also suggest that the reduction in miR-21 expression intensifies cardiac hypertrophy, gene expression of fibrosis markers, interstitial fibrosis and perivascular disorders, and cardiac dysfunction [58].…”

Section: Discussionmentioning

confidence: 94%

Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

Krzywińska

Bracha

Jeannière

et al. 2020

BioMed Research International

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MicroRNAs (miRNAs) are short and noncoding RNA fragments that bind to the messenger RNA. They have different roles in many physiological or pathological processes. MicroRNA-21, one of the first miRNAs discovered, is encoded by the MIR21 gene and is located on the chromosomal positive strand 17q23.2. MicroRNA-21 is transcribed by polymerase II and has its own promoter sequence, although it is in an intron. It is intra-and extracellular and can be found in many body fluids, alone or combined with another molecule. It regulates many signalling pathways and therefore plays an important role in the cardiovascular system. Indeed, it is involved in the differentiation and migration of endothelial cells and angiogenesis. It contributes to the reconstruction of a myocardial infarction, and it can also act as a cellular connector or as an antagonist to cardiac cell apoptosis. By playing all these roles, it can be interesting to use it as a biomarker, especially for cardiovascular diseases.

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miR-1, miR-21, and galectin-3 in hypertensive patients with symptomatic heart failure and left ventricular hypertrophy

Cited by 15 publications

References 0 publications

Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic Patients

Clinical Value of Circulating Microribonucleic Acids miR-1 and miR-21 in Evaluating the Diagnosis of Acute Heart Failure in Asymptomatic Type 2 Diabetic Patients

Combined detection of miR-21-5p, miR-30a-3p, miR-30a-5p, miR-155-5p, miR-216a and miR-217 for screening of early heart failure diseases

Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

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