miR-100-5p Is a Novel Biomarker That Suppresses the Proliferation, Migration, and Invasion in Skin Cutaneous Melanoma

Abstract

Description. Cutaneous melanoma (SKCM) is one of the most common skin malignancies. miR-100-5 has been found to highly express microRNAs in a variety of cancers. This is a novel biomarker to inhibit the proliferation, migration, and invasion of cutaneous melanoma. However, its function and potential mechanisms in SKCM remain unknown. Objective. To better understand the role and underlying mechanisms of SKCM, we conducted bioinformatics analysis and in vivo experiments. Results. We found its role as a tumor suppressor gene in SKCM and its effect on prognosis. In addition, this study found that miR-100-5p had a bidirectional effect on SKCM microenvironment. After exploring the relationship between the two, it was found that tumors with intermediate miR-100-5p expression had the highest level of immune cell infiltration. In addition, the value of miR-100-5p was assessed by survival analysis, univariate Cox regression analysis, and nomogram prognostic prediction. Finally, we constructed a regulatory network to illustrate the regulatory relationship of miR-100-5p. Conclusions. In conclusion, the antitumor effect of miR-100-5p is revealed, and the present study is followed by a discussion of its molecular regulatory network, followed by novel insights into SKCM therapy.

Screening and identification of key biomarkers associated with amyotrophic lateral sclerosis and depression using bioinformatics

“…[66] miR-100-5p can affect cell proliferation, migration, invasion, and apoptosis, including BC cells and SKCM cells. [67,68] miR-30b-5p significantly affects various biological processes including cell differentiation, oxidative stress, apoptosis, and protein stability. [69]…”

“…[66] miR-100-5p can affect cell proliferation, migration, invasion, and apoptosis, including BC cells and SKCM cells. [67,68] miR-30b-5p significantly affects various biological processes including cell differentiation, oxidative stress, apoptosis, and protein stability. [69] miR-615-3p not only plays important roles in various tumor diseases and skeletal development, but has also been shown to be involved to some extent in neurodegenerative diseases.…”

Retracted: miR-100-5p Is a Novel Biomarker That Suppresses the Proliferation, Migration, and Invasion in Skin Cutaneous Melanoma

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”