miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes

Parrizas, Marcelina; Mundet, Xavier; Castaño, Carlos; Canivell, Sílvia; Cos, Xavier; Brugnara, Laura; Giráldez‐García, Carolina; Regidor, Enrique; Mata-Cases, Manel; Franch-Nadal, Josep; Novials, Anna

doi:10.1007/s40618-019-01129-z

Cited by 39 publications

(31 citation statements)

References 37 publications

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“…miR-491-5p, miR-1307-3p, and miR-298, have also been recognized, as predictive tools of T2D in prediabetes patients [ 57 , 58 ]. In a recent study, Parrizas et al provided evidence for the existence of a circulating miRNA signature for prediabetes by identifying two different miRNAs, miR-10b and miR-223-3p, whose combination was able to differentiate between progressor and non-progressor prediabetic subjects at a stage at which other features, including glycaemia, are less useful in separating them [ 59 ]. That study was conducted on a subset of extracellular miRNAs enclosed inside microvesicles and highlights the ability of miRNA screening as a useful tool for adult subjects at risk of developing diabetes.…”

Section: Discussionmentioning

confidence: 99%

The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study

et al. 2021

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Background In recent years, the exciting emergence of circulating miRNAs as stable, reproducible, and consistent among individuals has opened a promising research opportunity for the detection of non-invasive biomarkers. A firm connection has been established between circulating miRNAs and glycaemic as well as metabolic homeostasis, showing that levels of specific miRNAs vary under different physio-pathological conditions. Objective In this pilot study, we investigated the expression of candidate miRNAs, hsa-miR-191-3p and hsa-miR-375, in relation to biomarkers associated with insulin sensitivity in a subgroup (n=58) of subjects participating to the European I.Family Study, a project aimed to assess the determinants of eating behaviour in children and adolescents and related health outcomes. The sample included overweight/obese children/adolescents since overweight/obesity is a known risk factor for impaired glucose homeostasis and metabolic disorders. Biological targets of candidate miRNAs were also explored in silico. Results We observed a significant association of the two miRNAs and early changes in glycaemic homeostasis, independent of covariates including country of origin, age, BMI z-score, puberty status, highest educational level of parents, total energy intake, energy from fats, energy from carbohydrates, and energy from proteins. Conclusion Identification of circulating miRNAs associated with insulin impairment may offer novel approaches of assessing early variations in insulin sensitivity and provide evidence about the molecular mechanisms connected to early changes in glycaemic homeostasis. Trial registration ISRCTN, ISRCTN62310987. Retrospectively registered, http://isrctn.com/ISRCTN62310987

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Section: Discussionmentioning

confidence: 99%

The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study

et al. 2021

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“…Insulin autoantibodies were negatively associated to miR-10b-5p [58]. miR-10b targeted components of the insulin signaling pathway [133]. Vitro studies showed the overexpression of miR-10b led to chemoresistance in CRC cells to 5-FU [134].…”

Section: Microrna Biomarkersmentioning

confidence: 98%

MicroRNA, Diabetes Mellitus and Colorectal Cancer

Wang

2020

Biomedicines

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Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to these complications, DM was reported to be associated with different cancers. In this review, we discuss the association between DM and colorectal cancer (CRC). CRC is the third most commonly diagnosed cancer worldwide that mostly affects older people, however, its incidence and mortality are rising among young people. We discuss the relationship between DM and CRC based on their common microRNA (miRNA) biomarkers. miRNAs are non-coding RNAs playing important functions in cell differentiation, development, regulation of cell cycle, and apoptosis. miRNAs can inhibit cell proliferation and induce apoptosis in CRC cells. miRNAs also can improve glucose tolerance and insulin sensitivity. Therefore, investigating the common miRNA biomarkers of both DM and CRC can shed a light on how these two diseases are correlated and more understanding of the link between these two diseases can help the prevention of both DM and CRC.

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“…It is to note that the feasibility of using miR‐223 serum levels as biomarker is not only being exploited in cancer patients, but also in a wide range of other pathologies, ranging from neurodegenerative diseases like Parkinson, Alzheimer and dementia (Jia & Liu, 2016 ; Mancuso et al, 2019 ; Wei et al, 2018 ) to arthritis (Dunaeva et al, 2018 ), diabetes (Parrizas et al, 2020 ) and bacterial peritonitis (Brook et al, 2019 ). Given the deep involvement of miR‐223 in inflammation and immune response, particularly in the respiratory tract (Bauernfeind et al, 2012 ; Dorhoi et al, 2013 ; Feng et al, 2017 ; Neudecker et al, 2017 ), it will not be surprising to discover that miR‐223 plays a central role in SARS‐CoV 2 pathogenesis and may be exploitable as either biomarker or therapeutic target.…”

Section: Mir ‐223 As Potential Biomarkermentioning

confidence: 99%

The many facets of miR‐223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response

et al. 2021

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Given their intrinsic pleiotropism, microRNAs (miR) play complex biological roles, in both normal and pathological conditions. Often the same miR can act as oncogene or oncosuppressor, depending on the biological process dysregulated in each specific tissue. miR-223 does not represent an exception to this rule and its functions greatly differ in different contexts. miR-223 has been widely studied in the hematopoietic compartment, where it plays a central role in innate immune response, regulating myeloid differentiation and granulocytes function. Accordingly, dysregulated expression of miR-223 has been associated to different inflammatory disorders and tumors arising from the immune compartment. Most carcinomas, breast cancer being the most studied, display loss of miR-223. However, in gastro-esophageal cancers miR-223 is frequently overexpressed and correlates with worse prognosis. A link between miR-223 and response to CDK4/6-inhibitors has been recently proposed, suggesting a role as biomarker of therapeutic response. The notion that one of the most commonly mutated protein in cancer, mutant p53, binds the promoter of miR-223 and suppresses its transcription, adds a further level of complexity to the full understanding of miR-223 in cancer. In this review, we will summarize the current knowledge on the molecular networks that alter or are altered by miR-223, in different cancer types. We will discuss if the times are ready for the exploitation of miR-223 as predictive biomarker of treatment response or, even, as therapeutic target, in specific settings. Finally, we will suggest which could be the next steps to be taken for a realistic clinical application of miR-223.

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miR-10b and miR-223-3p in serum microvesicles signal progression from prediabetes to type 2 diabetes

Cited by 39 publications

References 37 publications

The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study

The association of circulating miR-191 and miR-375 expression levels with markers of insulin resistance in overweight children: an exploratory analysis of the I.Family Study

MicroRNA, Diabetes Mellitus and Colorectal Cancer

The many facets of miR‐223 in cancer: Oncosuppressor, oncogenic driver, therapeutic target, and biomarker of response

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