miR-1202 acts as anti-oncomiR in myeloid leukaemia by down-modulating GATA-1
S
expression
Raffaele Sessa,
Silvia Trombetti,
Alessandra Lo Bianco
et al.
Abstract:Transient abnormal myelopoiesis (TAM) is a Down syndrome-related pre-leukaemic condition characterized by somatic mutations in the haematopoietic transcription factor GATA-1 that result in exclusive production of its shorter isoform (GATA-1
S
). Given the common hallmark of altered miRNA expression profiles in haematological malignancies and the pro-leukaemic role of GATA-1
S
, we aimed to search for miRNAs potentially able to modulate the expression of GATA-1 is… Show more
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