MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1

Li, Yan; N, Yao; Gao, Yan; Wang, Yunping; Bai, Linquan; Xu, Jia; Wang, Haixu

doi:10.1080/21655979.2021.1987125

Cited by 23 publications

(17 citation statements)

References 70 publications

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“…In PCOS, miR-1224-5p deactivates the NLRP3 inflammasome via FoxO1 [ 130 ]. The ability of granulosa cells to produce mature oocytes is arrested because of inflammatory reactions, which have also been confirmed in patients with PCOS [ 131 ].…”

Section: Molecular Pathologymentioning

confidence: 99%

Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome

Khan

Kim

et al. 2023

IJMS

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A significant fraction of couples around the world suffer from polycystic ovarian syndrome (PCOS), a disease defined by the characteristics of enhanced androgen synthesis in ovarian theca cells, hyperandrogenemia, and ovarian dysfunction in women. Most of the clinically observable symptoms and altered blood biomarker levels in the patients indicate metabolic dysregulation and adaptive changes as the key underlying mechanisms. Since the liver is the metabolic hub of the body and is involved in steroid-hormonal detoxification, pathological changes in the liver may contribute to female endocrine disruption, potentially through the liver-to-ovary axis. Of particular interest are hyperglycemic challenges and the consequent changes in liver-secretory protein(s) and insulin sensitivity affecting the maturation of ovarian follicles, potentially leading to female infertility. The purpose of this review is to provide insight into emerging metabolic mechanisms underlying PCOS as the primary culprit, which promote its incidence and aggravation. Additionally, this review aims to summarize medications and new potential therapeutic approaches for the disease.

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Section: Molecular Pathologymentioning

confidence: 99%

Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome

Khan

Kim

et al. 2023

IJMS

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“…[103] miR-1224-5p was proven to . [104] Therefore, miR-1224-5p-dependent NLRP3 inflammasome regulation may offer a potentail target for PCOS treatment (Table 1).…”

Section: Guo Et Almentioning

confidence: 99%

“…(2021) [104] In vitro: Upregulation of miR-1224-5p − Inhibited the production of testosterone and DHEA − Attenuated inflammation by suppressing NF-κB p65, NLRP3 inflammasome, and IL-1β − Decreased the expression of FOXO1 and its downstream gene TXNIP − FOXO1 was confirmed as a target of miR-1224-5p. − The downregulation of miR-1224-5p was found to be linked to an elevated activation of the NLRP3 inflammasome.…”

Section: Et Almentioning

confidence: 99%

Inhibition of NLRP3 inflammasome—A potential mechanistic therapeutic for treatment of polycystic ovary syndrome?

Chamanara,

Hozouri,

Irandoost

2023

J Biochem & Molecular Tox

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This review article explores the relationship between the NOD‐like receptor protein 3 (NLRP3) inflammasome and the risk of developing polycystic ovary syndrome (PCOS). The NLRP3 inflammasome, a fundamental element of the innate immune system, plays a crucial role in the production of proinflammatory mediators and pyroptosis, a type inflammatory cell death. We conducted a thorough search on scientific databases to gather relevant information on this topic, utilizing relevant keywords. The reviewed studies indicated a correlation between PCOS and a higher incidence of granulosa cell (GC) death and the presence of ovarian tissue fibrosis. NLRP3 inflammasome stimulation and subsequent pyroptosis in GCs play a significant role in the pathophysiology of PCOS. Active NLRP3 inflammasome is involved in the production of inflammatory mediators like interleukin‐1β (IL‐1β) and IL‐18, contributing to the development of PCOS, particularly in overweight patients. Therefore, inhibiting NLRP3 activation and pyroptosis could potentially offer novel therapeutic strategies for PCOS. Some limited studies have explored the use of agents with antioxidant and anti‐inflammatory properties, as well as gene therapy approaches, to target the NLRP3 and pyroptosis signaling pathways. This study overview the understanding of the relationship between NLRP3 inflammasome activation, pyroptosis, and PCOS. It highlights the potential of targeting the NLRP3 inflammasome as an approach for treating PCOS. Nonetheless, further research and clinical trials are imperative to validate these results and explore the effectiveness of NLRP3 inflammasome inhibition in the management of PCOS.

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“…Another study demonstrated that CCL2 as the main target of miR-374a-5p, and also demonstrated that the transcription factor NF-kB can activate CCL2, suggesting that miR-374a-5p may play a role in regulating inflammatory responses (109). Li et al described that miR-1224-5p exerts anti-inflammatory effects and alleviates PCOS by inhibiting the activation of the NF-kB signaling pathway (141).…”

Section: Nf-kb Pathwaymentioning

confidence: 99%

“…Li et al. described that miR-1224-5p exerts anti-inflammatory effects and alleviates PCOS by inhibiting the activation of the NF-κB signaling pathway ( 141 ).…”

Section: Possible Pathways Of Mirna-mediated Pcosmentioning

confidence: 99%

Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms

Chen

Huang²,

Wang³

et al. 2022

Front. Endocrinol.

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Polycystic ovary syndrome (PCOS) is a reproductive dysfunction associated with endocrine disorders and is most common in women of reproductive age. Clinical and/or biochemical manifestations include hyperandrogenism, persistent anovulation, polycystic ovary, insulin resistance, and obesity. Presently, the aetiology and pathogenesis of PCOS remain unclear. In recent years, the role of circadian rhythm changes in PCOS has garnered considerable attention. Changes in circadian rhythm can trigger PCOS through mechanisms such as oxidative stress and inflammation; however, the specific mechanisms are unclear. Exosomes are vesicles with sizes ranging from 30–120nm that mediate intercellular communication by transporting microRNAs (miRNAs), proteins, mRNAs, DNA, or lipids to target cells and are widely involved in the regulation of various physiological and pathological processes. Circadian rhythm can alter circulating exosomes, leading to a series of related changes and physiological dysfunctions. Therefore, we speculate that circadian rhythm-induced changes in circulating exosomes may be involved in PCOS pathogenesis. In this review, we summarize the possible roles of exosomes and their derived microRNAs in the occurrence and development of PCOS and discuss their possible mechanisms, providing insights into the potential role of exosomes for PCOS treatment.

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MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1

Cited by 23 publications

References 70 publications

Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome

Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome

Inhibition of NLRP3 inflammasome—A potential mechanistic therapeutic for treatment of polycystic ovary syndrome?

Therapeutic potential of exosomes/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms

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