miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death

Jin, Caining; Rajabi, Hasan; Küfe, Donald

doi:10.3892/ijo_00000653

Cited by 27 publications

(13 citation statements)

References 43 publications

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“…miR-1226 was reported to be involved in tumorigenesis, angiogenesis and drug resistance in breast cancer and non-small cell lung cancer [23, 24]. The correlation between hsa-miR-1226-3p and MUC1 has also been proved by the previous study which revealed that miR-1226 interacted with the MUC1 mRNA 3’ UTR and induced downregulation of MUC1 [25].…”

Section: Discussionmentioning

confidence: 95%

The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma

Huang

Meng

Chen

et al. 2019

Aging

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Soft tissue sarcoma (STS) is one of the most challenging tumors for medical oncologists, with a high rate of recurrence after initial resection. In this study, a recurrent STS-specific competitive endogenous RNA (ceRNA) network including seven recurrence and overall survival (OS)-associated genes (LPP-AS2, MUC1, GAB2, hsa-let-7i-5p, hsa-let-7f-5p, hsa-miR-101-3p and hsa-miR-1226-3p) was established based on the gene expression profiling of 259 primary sarcomas and 3 local recurrence samples from the TCGA database. The algorithm “cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT)” was applied to estimate the fraction of immune cells in sarcomas. Based on 5 recurrence and OS-associated immune cells (NK cells activated, dendritic cells resting, mast cells resting, mast cells activated and macrophages M1), we constructed a recurrent STS-specific immune cells network. Both nomograms were identified to have good reliabilities (Area Under Curve (AUC) of 5-year survival is 0.724 and 0.773, respectively). Then the co-expression analysis was performed to identify the potential regulation network among recurrent STS-specific immune cells and ceRNAs. Hsa-miR-1226-3p and MUC1 were significantly correlated and dendritic cells resting was related to hsa-miR-1226-3p. Additionally, the expression of MUC1 and dendritic cell marker CD11c were also verified by immunohistochemistry (IHC) assay and multidimensional databases. In conclusion, this study illustrated the potential mechanism of hsa-miR-1226-3p regulating MUC1 and dendritic cells resting might play an important role in STS recurrence. These findings might provide potential prognostic biomarkers and therapeutic targets for recurrent STS.

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Section: Discussionmentioning

confidence: 95%

The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma

Huang

Meng

Chen

et al. 2019

Aging

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“…1 ). Most recently, downregulation of MUC1 expression by micro-RNA has been reported by several groups (Jin et al 2010 ; Rajabi et al 2010 ; Sachdeva and Mo 2010 ). Sachdeva and Mo showed that miR-145 directly targets MUC1 by interaction with the 3 ′ -UTR and found that miR-145 acts as a tumor suppressor in part by affecting invasion and metastasis by targeting MUC1 (Sachdeva and Mo 2010 ).…”

Section: Functional Role and Epigenetic Regulation Mechanisms Of Mucimentioning

confidence: 91%

“…In breast cancer cells, Rajabi et al indicated that miR-125b suppresses translation of the MUC1 and that miR-125b thereby functions as a tumor suppressor (Rajabi et al 2010 ). Jin et al showed that MUC1 expression is suppressed by miR-1226 and that miR-1226-induced downregulation of MUC1 is correlated with cell death of MUC1-positive breast cancer cells (Jin et al 2010 ). These findings suggest the possible functional importance of MUC1 under both physiological and pathological conditions.…”

Section: Functional Role and Epigenetic Regulation Mechanisms Of Mucimentioning

confidence: 99%

“…Among mucin genes, MUC1 expression has been shown to be directly downregulated by miR-145, with the further finding that miR-145 acts as a tumor suppressor in cell invasion and metastasis by targeting MUC1 (Sachdeva and Mo 2010 ). miR-125b and miR-1226 have also been reported to target MUC1 expression (Jin et al 2010 ), and it is likely that these miRNAs could be attractive targets for therapeutic intervention in advanced cancers.…”

Section: Conclusion and Clinical Perspectivesmentioning

confidence: 99%

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Epigenetic regulation of mucin genes in human cancers

et al. 2011

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Mucins are high molecular weight glycoproteins that play important roles in diagnostic and prognostic prediction and in carcinogenesis and tumor invasion. Regulation of expression of mucin genes has been studied extensively, and signaling pathways, transcriptional regulators, and epigenetic modification in promoter regions have been described. Detection of the epigenetic status of cancer-related mucin genes is important for early diagnosis of cancer and for monitoring of tumor behavior and response to targeted therapy. Effects of micro-RNAs on mucin gene expression have also started to emerge. In this review, we discuss the current views on epigenetic mechanisms of regulation of mucin genes (MUC1, MUC2, MUC3A, MUC4, MUC5AC, MUC5B, MUC6, MUC16, and MUC17) and the possible clinical applications of this epigenetic information.

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“…Interrogation of MiRbase and MiRanda databases revealed a large number of miRNAs that could potentially target the 3′-UTR of mucin genes including MUC1 , MUC4 , MUC17 or MUC2 , MUC5AC , and MUC6 [ 66 ]. Very recent data indeed indicate that the MUC1 3’-UTR is directly regulated by miR-125b, miR-145 and miR-1226 in human breast cancer cell line [ 76 , 77 , 78 ].…”

Section: Epigenetic Regulation Of Mucin Genes In Pancreatic Cancermentioning

confidence: 99%

Mucins and Pancreatic Cancer

Jonckheere

Skrypek

Seuningen

2010

Cancers

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Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins. Secreted mucins are the main component of mucus protecting the epithelia whereas membrane-bound mucins are thought to play important biological roles in cell-cell and cell-matrix interactions, in cell signaling and in modulating biological properties of cancer cells. In this review, we will focus on the altered expression pattern of mucins in pancreatic cancer, from the early neoplastic lesion Pancreatic Intraepithelial Neoplasia (PanIN) to invasive pancreatic carcinomas, and the molecular mechanisms (including genetic and epigenetic regulation) and signaling pathways known to control their expression. Moreover, we will discuss the recent advances about the biology of both secreted and membrane-bound mucins and their key roles in pancreatic carcinogenesis and resistance to therapy. Finally, we will discuss exciting opportunities that mucins offer as potential therapeutic targets in pancreatic cancer.

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miR-1226 targets expression of the mucin 1 oncoprotein and induces cell death

Cited by 27 publications

References 43 publications

The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma

The construction and analysis of tumor-infiltrating immune cell and ceRNA networks in recurrent soft tissue sarcoma

Epigenetic regulation of mucin genes in human cancers

Mucins and Pancreatic Cancer

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