MiR-125 Family in Cardiovascular and Cerebrovascular Diseases

Abstract

Cardiovascular and cerebrovascular diseases are a serious threaten to the health of modern people. Understanding the mechanism of occurrence and development of cardiovascular and cerebrovascular diseases, as well as reasonable prevention and treatment of them, is a huge challenge that we are currently facing. The miR-125 family consists of hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. It is a kind of miRNA family that is highly conserved among different species. A large amount of literature shows that the lack of miR-125 can cause abnormal development of the cardiovascular system in the embryonic period. At the same time, the miR-125 family participates in the occurrence and development of a variety of cardiovascular and cerebrovascular diseases, including myocardial ischemia, atherosclerosis, ischemia-reperfusion injury, ischemic stroke, and heart failure directly or indirectly. In this article, we summarized the role of the miR-125 family in the development and maturation of cardiovascular system, the occurrence and development of cardiovascular and cerebrovascular diseases, and its important value in the current fiery stem cell therapy. In addition, we presented this in the form of table and diagrams. We also discussed the difficulties and challenges faced by the miR-125 family in clinical applications.

Exosome-Loaded Pro-efferocytic Vascular Stent with Lp-PLA2-Triggered Release for Preventing In-Stent Restenosis

“…Exosome contains not just a variety of proteins, it also encapsulates genetic substances. MicroRNA sequencing disclosed more than 400 total miRNAs, specifically including those associated with oxidation regulation, vascular calcification, and SMCs’ plasticity (mir-125 family, − mir-143), anti-inflammation (mir-16–5p), tissue repair (let-7 family), and cholesterol hemostasis (mir-26, mir-148) (Figure H). These results suggested that MSCs-Exo was successfully extracted, and it conveys contents that have the potential to regulate efferocytosis process, lipid metabolism, SMCs’ phenotype transformation, and oxidation.…”

Expression profiling analysis reveals key microRNA–mRNA interactions in patients with transposition of the great arteries and systemic left and right ventricles

“…In this study, we identified six miRNAs including miR-125a-5p, miR-125b-5p, miR-181b-5p, miR-19a-3p, miR-20a-5p, and miR-30b-5p were significantly associated with heart failure (HF) ( Supplementary Table 4 ). Of these six miRNAs, the miR-125 family was previously reported to be dysregulated and significantly correlated with HF and many other cardiac manifestations ( 12 , 33 – 35 ). Also, miR-19, miR-181, miR-125, and miR-30 levels were associated with myocardium levels during the development of diabetic cardiomyopathy and failing hearts ( 33 , 36 ), and the miR-30 and miR-19 families were frequently reported to be dysregulated in patients with the acute coronary syndrome (ACS) ( 37 ).…”

miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium

“…Apoptotic cell death is linked to low expression of miR-498 in MI patients [47] and is in agreement with the downregulation in our array. MiRNAs with a negative correlation between cardiac remodeling and the direction of regulation in our array, such as miR-28 [48,49], miR-374c [50], and miR-125a [51] are likely part of an early coping mechanism.…”