MiR-1256 inhibits cell proliferation and cell cycle progression in papillary thyroid cancer by targeting 5-hydroxy tryptamine receptor 3A

Wu, Cunkai; Ma, Liyuan; Wei, Hongfa; Nie, Furong; Ning, Jie; Jiang, Tao

doi:10.1007/s13577-020-00325-x

Cited by 22 publications

(11 citation statements)

References 33 publications

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“…Moreover, miR-198 and miR-217 may be highly specific as diagnostic and differentiating biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma [ 30 ]. Furthermore, miR-409 dysregulation has also been shown in PDAC; low expression was associated with poor outcomes, and miR-409 was reported to downregulate GAB-1 and antagonize PD-L1 action, a key molecule in immune checkpoint control [ 41 , 42 ]. Recent studies also revealed that different alterations in the signal transduction pathways are altered in response to the dysregulation of miR-409 and miR-490-3p.…”

Section: Microrna Dysregulation In Tumor Tissue Of Patients With Pdac...mentioning

confidence: 99%

“…Recent studies also revealed that different alterations in the signal transduction pathways are altered in response to the dysregulation of miR-409 and miR-490-3p. While miR-490 downregulates GAB-1 and antagonizes PD-L1 action, a key molecule in immune checkpoint control [ 41 , 42 ], miR-490-3p seems to suppress growth and metastasis in cell lines by targeting SMARCD1 [ 43 ].…”

Section: Microrna Dysregulation In Tumor Tissue Of Patients With Pdac...mentioning

confidence: 99%

“…This SNP is located in the lnc-SMC2-1 gene and has been reported to disrupt the binding of the lncRNA with miR-1256, which regulates several genes involved in the cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic, and its genetic variants have been associated with several human diseases, possibly though the interaction between lncRNA and miRNA [ 42 ]. A link to hyperinsulinemia could also be possible, linking HbA1c expression panels with the dysregulation of miRNAs such as miR-1246, miR-1256, and miR-1290 [ 44 , 45 , 53 ].…”

Section: Microrna Dysregulation In Tumor Tissue Of Patients With Pdac...mentioning

confidence: 99%

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MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions

Prinz

Fehring

Frese

2022

Cells

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The dysregulation of microRNAs has recently been associated with cancer development and progression in pancreatic ductal adenocarcinoma (PDAC) and cystic pancreatic lesions. In solid pancreatic tumor tissue, the dysregulation of miR-146, miR-196a/b, miR-198, miR-217, miR-409, and miR-490, as well as miR-1290 has been investigated in tumor biopsies of patients with PDAC and was reported to predict cancer presence. However, the value of the predictive biomarkers may further be increased during clinical conditions suggesting cancer development such as hyperinsulinemia or onset of diabetes. In this specific context, the dysregulation of miR-486 and miR-196 in tumors has been observed in the tumor tissue of PDAC patients with newly diagnosed diabetes mellitus. Moreover, miR-1256 is dysregulated in pancreatic cancer, possibly due to the interaction with long non-coding RNA molecules that seem to affect cell-cycle control and diabetes manifestation in PDAC patients, and, thus, these three markers may be of special or “sentinel value”. In blood samples, Next-generation sequencing (NGS) has also identified a set of microRNAs (miR-20a, miR-31-5p, miR-24, miR-25, miR-99a, miR-185, and miR-191) that seem to differentiate patients with pancreatic cancer remarkably from healthy controls, but limited data exist in this context regarding the prediction of cancer presences and outcomes. In contrast to solid pancreatic tumors, in cystic pancreatic cancer lesions, as well as premalignant lesions (such as intraductal papillary neoplasia (IPMN) or mucinous-cystic adenomatous cysts (MCAC)), the dysregulation of a completely different expression panel of miR-31-5p, miR-483-5p, miR-99a-5p, and miR-375 has been found to be of high clinical value in differentiating benign from malignant lesions. Interestingly, signal transduction pathways associated with miR-dysregulation seem to be entirely different in patients with pancreatic cysts when compared to PDAC. Overall, the determination of these different dysregulation “panels” in solid tumors, pancreatic cysts, obtained via fine-needle aspirate biopsies and/or in blood samples at the onset or during the treatment of pancreatic diseases, seems to be a reasonable candidate approach for predicting cancer presence, cancer development, and even therapy responses.

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Section: Microrna Dysregulation In Tumor Tissue Of Patients With Pdac...mentioning

confidence: 99%

Section: Microrna Dysregulation In Tumor Tissue Of Patients With Pdac...mentioning

confidence: 99%

Section: Microrna Dysregulation In Tumor Tissue Of Patients With Pdac...mentioning

confidence: 99%

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MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions

Prinz

Fehring

Frese

2022

Cells

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“…For example, miR-100-5p inhibits proliferation, migration, and invasion of prostate cancer cells ( 8 ). MiR-1256 is downregulated in papillary thyroid cancer, and restoring its expression inhibits cancer cell growth by repressing proliferation-associated proteins including PCNA, CDK4, and cyclin D1 ( 9 ). Evidence suggests that several miRNAs also have anti-radiation resistance effects in tumors.…”

Section: Introductionmentioning

confidence: 99%

Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway

et al. 2022

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Purpose: The purpose of this study was to analyze the effects of miR-640–SLIT1 axis and the Wnt/β-catenin signaling pathway on radiosensitivity of glioma cells.Methods: Relative expressions of miR-640 and slit guidance ligand 1 (SLIT1) in glioma tissues and glioma cell lines U251 and A172 were detected using RT-qPCR. The cell lines were transfected with si-SLIT1 or miR-640 inhibitor to study the radiosensitivity of glioma cells. We detected cell activity using CCK-8 assay, cell migration using wound healing assay, cell invasion using transwell assay, and apoptosis using caspase-3 assay.Results: SLIT1 was upregulated in glioma tissues and cell lines, and inversely correlated with radiation sensitivity. Its knockdown reduced radioresistance, migration, and invasion, but increased apoptosis in U251 and A17 cells. Loss of miR-640 activity upregulated SLIT1, Wnt, and β-catenin protein expression, whereas it inhibited p-GSK-3β protein levels in U251 and A17 cells. These results suggest that miR-640 mediates the radiosensitivity of glioma cells through SLIT1 and the Wnt/β-catenin signaling pathway.Conclusion: The miR-640–SLIT1 axis that regulates the Wnt/β-catenin signaling pathway is a possible therapeutic option for the effective treatment of glioma in combination with radiotherapy.

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“…According to the prediction of biological software, circ_0025033 has a binding site with miR-1256. It is reported that the high expression of miR-1256 can inhibit the cell proliferation and cell cycle progression of papillary thyroid carcinoma [6] . The expression of miR-1256 is down-regulated in nonsmall cell lung cancer tissues and the overexpression of miR-1256 inhibits the proliferation and migration of non-small cell lung cancer cells [7] .…”

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confidence: 99%

Mechanism of Regulating the Proliferation, Migration and Invasion of Cervical Cancer Hela Cells by Circular RNA Circ_0025033 Targeting microRNA 1256

He¹,

Huang²

2021

ijps

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To explore the effect of circular RNA_0025033 on the proliferation, migration and invasion of cervical cancer HeLa cells and its molecular mechanism. The cancer tissues and adjacent tissues of 39 patients with cervical cancer in our hospital from January 2017 to December 2020 were selected. The expression levels of circular RNA_0025033 and microRNA-1256 were detected by Quantitative reverse transcription polymerase chain reaction. Cell counting kit 8 was used to detect cell viability. Plate cloning test was conducted to detect the number of cell clones. Scratch test was carried out to detect cell scratch healing rate. Transwell chamber was used to detect cell invasion. Western blot was adopted to detect protein expression. Dual luciferase reporter assay was carried out to detect the targeting relationship between circular RNA_0025033 and microRNA-1256. The expression level of circular RNA_0025033 in cervical cancer tissues was increased and the expression level of microRNA-1256 was decreased (p<0.05). After inhibiting the expression of circular RNA_0025033 or overexpression of microRNA-1256, cell viability was decreased and the number of cell clone formation was decreased. The healing rate of cell scratches was decreased and the number of invasive cells was decrease. E-cadherin expression was increased and N-cadherin expression was decreased (p<0.05). Circular RNA_0025033 targeted regulation of the expression of microRNA-1256 was carried out; interference with microRNA-1256 expression reversed the inhibition of circular RNA_0025033 on the proliferation, migration and invasion of cervical cancer HeLa cells. Inhibition of circular RNA_0025033 expression may inhibit the proliferation, migration and invasion of cervical cancer HeLa cells through targeted regulation of microRNA-1256.

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MiR-1256 inhibits cell proliferation and cell cycle progression in papillary thyroid cancer by targeting 5-hydroxy tryptamine receptor 3A

Cited by 22 publications

References 33 publications

MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions

MicroRNAs as Indicators of Malignancy in Pancreatic Ductal Adenocarcinoma (PDAC) and Cystic Pancreatic Lesions

Micro RNA-640 Targeting SLIT1 Enhances Glioma Radiosensitivity by Restraining the Activation of Wnt/β-Catenin Signaling Pathway

Mechanism of Regulating the Proliferation, Migration and Invasion of Cervical Cancer Hela Cells by Circular RNA Circ_0025033 Targeting microRNA 1256

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