miR-126 functions as a tumour suppressor in human gastric cancer

Feng, Runhua; Chen, Xuehua; Yu, Yingyan; Yu, Beiqin; Li, Jianfang; Cai, Qing; Yan, Min; Liu, Bingya; Zhu, Zhenggang

doi:10.1016/j.canlet.2010.06.004

Cited by 262 publications

(235 citation statements)

References 33 publications

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“…Previous research of colon cancer (Li et al, 2013), cervical cancer (Yu et al, 2013) and gastric cancers (Feng et al, 2010) also observed down-regulated expression of miR-126. Moreover, it has been shown that retrovirus-mediated restoration of miR-126 expression in murine primary breast cancer cells caused the suppression of overall tumor growth and metastasis to the bone and lung (Sohail et al, 2008).…”

Section: Discussionmentioning

confidence: 64%

Characterization of the MicroRNA Expression Profile of Cervical Squamous Cell Carcinoma Metastases

Ding¹,

Wu²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Objectives: MicroRNAs (miRNAs) are important regulators of many physiological and pathological processes, including tumorigenesis and metastasis. In this study, we sought to determine the underlying molecular mechanisms of metastatic cervical carcinoma by performing miRNA profiling. Methods: Tissue samples were collected from ten cervical squamous cancer patients who underwent hysterectomy and pelvic lymph node (PLN) dissection in our hospital, including four PLN-positive (metastatic) cases and six PLN-negative (non-metastatic) cases. A miRNA microarray platform with 1223 probes was used to determine the miRNA expression profiles of these two tissue types and case groups. MiRNAs having at least 4-fold differential expression between PLN-positive and PLN-negative cervical cancer tissues were bioinformatically analyzed for target gene prediction. MiRNAs with tumor-associated target genes were validated by quantitative reverse transcription-polymerase chain reaction (RT-PCR). Results: Thirty-nine miRNAs were differentially expressed (>4-fold) between the PLN-positive and PLN-negative groups, of which, 22 were up-regulated and 17 were down-regulated. Sixty-nine percent of the miRNAs (27/39) had tumor-associated target genes, and the expression levels of six of those (miR-126, miR-96, miR-144, miR-657, miR-490-5p, and miR-323-3p) were confirmed by quantitative (q)RT-PCR. Conclusions: Six MiRNAs with predicted tumor-associated target genes encoding proteins that are known to be involved in cell adhesion, cytoskeletal remodeling, cell proliferation, cell migration, and apoptosis were identified. These findings suggest that a panel of miRNAs may regulate multiple and various steps of the metastasis cascade by targeting metastasis-associated genes. Since these six miRNAs are predicted to target tumor-associated genes, it is likely that they contribute to the metastatic potential of cervical cancer and may aid in prognosis or molecular therapy.

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Section: Discussionmentioning

confidence: 64%

Characterization of the MicroRNA Expression Profile of Cervical Squamous Cell Carcinoma Metastases

Ding¹,

Wu²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…miR-126 is relevant in many tumors, and studies have shown that miR-126 is significantly downregulated in gastric cancer tissues (Feng et al, 2010), non-small cell lung cancer cell lines (Zhu et al, 2012), prevalent diabetes mellitus (Zampetaki et al, 2010), cystic fibrosis airway epithelial cells (Oglesby et al, 2010), human breast cancer (Zhu et al, 2011), invasive ductal adenocarcinoma (Hamada et al, 2011), and cervical cancer tissues (Wang et al, 2008), as compared with relevant normal tissues. Using qRT-PCR analysis, we found that the expression of miR-126 in cervical cancer tissues was significantly decreased compare to that in normal cervical tissues, consistent with a previous report (Wang et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…miR-126 has been reported to affect cancer progression through signaling pathways that control tumor cell proliferation, migration, invasion, and survival (Feng et al, 2010;Hamada et al, 2011;van Solingen et al, 2011;Zhu et al, 2011;Zhu et al, 2012). Some studies have also demonstrated that miR-126 has roles in regulating adhesion molecule expression (Harris et al, 2008), providing additional control of vascular inflammation (Harris et al, 2008), regulating the VEGF/PI3K/AKT signaling pathway (Hu et al, 2010), regulating the translation and invasiveness of vascular endothelial cell sprouting (Musiyenko et al, 2008), and governing the integrity and angiogenesis of the vasculature (Kuhnert et al, 2008;Wang et al, 2008b).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have reported that miR-126 may play a role in tumorigenesis and growth by regulating the vascular endothelial growth factor (VEGF)/phosphoinositol 3-kinase (PI3K)/AKT signaling pathways in human breast cancer (Zhu et al, 2011). Additionally, this miRNA may function as a tumor suppressor, with Crk as a direct target, in gastric cancer (Feng et al, 2010) and via the regulation of ADAM9b in pancreatic cancer (Hamada et al, 2011). miR-126 may also play a role in angiogenesis in ischemia (van Solingen et al, 2011), and has also been reported to enhance the sensitivity of non-small cell lung cancer cells to anticancer agents by targeting VEGF-A (Zhu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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miR-126 Suppresses the Proliferation of Cervical Cancer Cells and Alters Cell Sensitivity to the Chemotherapeutic Drug Bleomycin

Liu²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…In contrast, the down‐regulation of miR‐126 enhances VEGFA activity in lung cancer, oral cancer and breast cancer,53, 54, 55, 56 and the restoration of miR‐126 decreases VEGF and tumour size in lung cancer 53, 57. In addition, miR‐126 inhibits gastric cancer angiogenesis by significantly reducing VEGFA expression and the activation of its downstream genes, Akt/protein kinase B, mTOR and Erk1/2 in the gastric cancer cell lines SGC‐7901, MKN‐28 and MKN‐45 27, 58. Furthermore, miR‐126‐3p inhibits angiogenesis in HCC by reducing LRP6 and PIK3R2,59 Thus, this suggests that miR‐126 inhibits tumour angiogenesis.…”

Section: Mirnas That Target Genes Involved In Angiogenesismentioning

confidence: 99%

The regulatory role of microRNAs in angiogenesis‐related diseases

Sun

Lei

et al. 2018

J Cellular Molecular Medi

119

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MicroRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression at a post‐transcriptional level via either the degradation or translational repression of a target mRNA. They play an irreplaceable role in angiogenesis by regulating the proliferation, differentiation, apoptosis, migration and tube formation of angiogenesis‐related cells, which are indispensable for multitudinous physiological and pathological processes, especially for the occurrence and development of vascular diseases. Imbalance between the regulation of miRNAs and angiogenesis may cause many diseases such as cancer, cardiovascular disease, aneurysm, Kawasaki disease, aortic dissection, phlebothrombosis and diabetic microvascular complication. Therefore, it is important to explore the essential role of miRNAs in angiogenesis, which might help to uncover new and effective therapeutic strategies for vascular diseases. This review focuses on the interactions between miRNAs and angiogenesis, and miRNA‐based biomarkers in the diagnosis, treatment and prognosis of angiogenesis‐related diseases, providing an update on the understanding of the clinical value of miRNAs in targeting angiogenesis.

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miR-126 functions as a tumour suppressor in human gastric cancer

Cited by 262 publications

References 33 publications

Characterization of the MicroRNA Expression Profile of Cervical Squamous Cell Carcinoma Metastases

Characterization of the MicroRNA Expression Profile of Cervical Squamous Cell Carcinoma Metastases

miR-126 Suppresses the Proliferation of Cervical Cancer Cells and Alters Cell Sensitivity to the Chemotherapeutic Drug Bleomycin

The regulatory role of microRNAs in angiogenesis‐related diseases

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