Mir-129-2-3p Has Tumor Suppressor Role in Ewing Sarcoma Cell Lines and Cancer Tissue Samples

Tanoglu, Esra Guzel; Arıkan, Yavuz; Kabukçuoğlu, Yavuz; Kabukçuoğlu, Fevziye; Tanoğlu, Alpaslan; Öztürk, Şükrü

doi:10.1590/1678-4324-2021210306

Cited by 2 publications

(2 citation statements)

References 24 publications

(28 reference statements)

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“…LncRNA H19 is an important maternally inherited oncogenic factor. It is effective in the malignancy of tumors by affecting specific miRNAs in many cancer types, such as PDAC [ 58 – 60 ]. H19 expression is significantly increased in metastatic PDAC.…”

Section: Lncrnas In Pancreas Cancermentioning

confidence: 99%

Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets

TANOĞLU,

ADIGÜZEL,

TANOĞLU

et al. 2023

Turkish Journal of Medical Sciences

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Long noncoding RNAs (lncRNAs) are noncoding RNA molecules with a heterogeneous structure consisting of 200 or more nucleotides. Because these noncoding RNAs are transcribed by RNA polymerase II, they have properties similar to messenger RNA (mRNA). Contrary to popular belief, the term “ncRNA” originated before the discovery of microRNAs. LncRNA genes are more numerous than protein-coding genes. They are the focus of current molecular research because of their pivotal roles in cancer-related processes such as cell proliferation, differentiation, and migration. The incidence of pancreatic cancer (PC) is increasing around the world and research on the molecular aspects of PC are growing. In this review, it is aimed to provide critical information about lncRNAs in PC, including the biological and oncological behaviors of lncRNAs in PC and their potential application in therapeutic strategies and as diagnostic tumor markers.

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Section: Lncrnas In Pancreas Cancermentioning

confidence: 99%

Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets

TANOĞLU,

ADIGÜZEL,

TANOĞLU

et al. 2023

Turkish Journal of Medical Sciences

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“…Overexpression of miR-129-2-3p significantly inhibits the proliferation and induces apoptosis of breast cancer cells ( Tang et al, 2016 ). The expression levels of miR-129-2-3p in Ewing sarcoma tumor tissue samples are significantly lower than those in corresponding adjacent normal tissue samples ( Tanoglu et al, 2021 ). The aberrant expression of the miR-129-2-3p is also detected in lung adenocarcinoma ( Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Rolling circle amplification (RCA) -based biosensor system for the fluorescent detection of miR-129-2-3p miRNA

Yan

Lin

Chi

et al. 2022

PeerJ

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Herein, a versatile fluorescent bioanalysis platform for sensitive and specific screening of target miRNA (miR-129-2-3p) was innovatively designed by applying target-induced rolling circle amplification (RCA) for efficient signal amplification. Specifically, miR-129-2-3p was used as a ligation template to facilitate its ligation with padlock probes, followed by an RCA reaction in the presence of phi29 DNA polymerase. The dsDNA fragments and products were stained by SYBR Green I and then detected by fluorescence spectrophotometry. As a result, miR-129-2-3p concentrations as low as 50 nM could be detected. Furthermore, the expression of miR-129-2-3p in breast cancer patients was about twice that in healthy people. Therefore, the results indicated that the RCA-based biosensor system could be a valuable platform for miRNA detection in clinical diagnosis and biomedical study.

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Mir-129-2-3p Has Tumor Suppressor Role in Ewing Sarcoma Cell Lines and Cancer Tissue Samples

Cited by 2 publications

References 24 publications

Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets

Long noncoding RNAs in pancreas cancer: from biomarkers to therapeutic targets

Rolling circle amplification (RCA) -based biosensor system for the fluorescent detection of miR-129-2-3p miRNA

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