miR‐129‐5p inhibits proliferation, migration, and invasion in rectal adenocarcinoma cells through targeting E2F7

Wan, Ping; Bai, Xuan; Yang, Chao; He, Tian; Luo, Lilin; Wang, Yun; Fan, Ming‐Yu; Wang, Zhilin; Lu, Liming; Yin, Yunqiang; Li, Sisi; Guo, Qiang; Song, Zheng-Yi

doi:10.1002/jcp.29501

Cited by 24 publications

(19 citation statements)

References 46 publications

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“…Recent studies have confirmed our conclusion: E2F7 has been proven to overexpressed in LUAD, and its expression is regulated by SNHG6 through the competitive sponging of miR-26a-5p, which promotes tumor growth and metastasis (25,26). E2F7 plays an indispensable role in a variety of tumors, such as gallbladder cancer (27), rectal adenocarcinoma (28), and breast cancer (29), indicating that E2F7 may be a potential prognostic marker. The high expression of E2F7 is related to short patient survival time and can promote NSCLC cell proliferation, migration, and invasion (30).…”

Section: Discussionsupporting

confidence: 77%

Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma

et al. 2020

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Background: A growing body of evidence indicates that long non-coding RNAs (lncRNAs) can act as competitive endogenous RNAs (ceRNAs) to bind to microRNAs (miRNAs), thereby affecting and regulating the expression of target genes. The lncRNA-miRNA-mRNA ceRNA network has been theorized to play an indispensable role in many types of tumors. However, the role of the lncRNA-related ceRNA regulatory network in lung adenocarcinoma (LUAD) remains unclear. Methods: We downloaded the RNAseq and miRNAseq data of LUAD from The Cancer Genome Atlas (TCGA) data portal and identified differentially expressed lncRNAs (DElncRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed mRNAs (DEmRNAs) between LUAD and corresponding paracancerous tissues by using the edgeR package of R software. We constructed the lncRNA-miRNA-mRNA ceRNA network by using Cytoscape (version 3.7.2) on the basis of the interaction generated from the miRcode, miRTarBase, miRDB, and TargetScan databases. Gene Ontology (GO) annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed with DAVID 6.8 bioinformatics resources and plotted by using the ggplot2 package in R. The effect of genes on LUAD prognosis was assessed by applying the survival package in R in accordance with the Kaplan-Meier curve. Results: In total, 1645 DElncRNAs, 117 DEmiRNAs, and 2729 DEmRNAs were identified in LUAD. The LUAD-specific ceRNA network was composed of 157 nodes and 378 edges (329 DElncRNA-DEmiRNA interactions and 49 DEmiRNA-DEmRNA interactions). GO and KEGG pathway annotations suggested that the LUAD-specific ceRNA network was related to tumor-related molecular functions and pathways.

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Section: Discussionsupporting

confidence: 77%

Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma

et al. 2020

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“…7 Accumulating evidence proves that miRs take part in the progression of CRC, such as miR-143 and miR-145. 8 As a tumor suppressor, miR-129-5p participates in various tumors, like rectal adenocarcinoma 9 and gastric cancer. 10 It is reported that miR-129-5p expression is declined in CRC cell lines, and miR-129-5p can impede cancer cell proliferation and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA PITPNA-AS1 Accelerates the Progression of Colorectal Cancer Through miR-129-5p/HMGB1 Axis

Yuan

Yang

2020

CMAR

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Background: Long non-coding RNAs (lncRNAs) are essential regulators in colorectal cancer (CRC) progression. This work aimed to delve into the characteristics of lncRNA PITPNA-AS1 in CRC. Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was adopted to examine PITPNA-AS1, miR-129-5p, high-mobility group box-1 (HMGB1) mRNA expressions in CRC tissues and cell lines. Functionally, cell counting kit-8 (CCK-8) and 5-ethynyl-2-deoxyuridine (EdU) incorporation assays were employed to examine cell proliferation; wound healing assay was utilized to detect cell migration; and flow cytometry was used to detect the cell apoptosis. Luciferase reporter assay, RNA immunoprecipitation assay and Western blot were conducted to detect the regulatory relationships among PITPNA-AS1, miR-129-5p and HMGB1. Results: PITPNA-AS1 and HMGB1 mRNA expressions were observably elevated in CRC tissues and cell lines. Knocking down PITPNA-AS1 could significantly inhibit cell proliferation and migration, and promote apoptosis of CRC cells. PITPNA-AS1 could serve as a competitive endogenous RNA, and up-regulate HMGB1 expression by adsorbing miR-129-5p. Conclusion: PITPNA-AS1 can expedite CRC cell proliferation and migration, and inhibit apoptosis through miR-129-5p/HMGB1 axis.

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“…E2F7 was identified as an miR-129-5p target that mediates miR-129-5p-induced effects. These results suggest that miR-129-5p could serve as an effective target for LARC that should be further studied [70].…”

Section: Mirnas As Potential Therapeutic Targets In Combination With mentioning

confidence: 83%

MicroRNAs in Rectal Cancer: Functional Significance and Promising Therapeutic Value

Imedio

Cristóbal

Rubio

et al. 2020

Cancers

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It is well-known that microRNAs (miRNAs) are critical mediators of initiation and disease progression in many human cancers. Rectal cancer is a highly prevalent tumor, accounting for around one third of newly diagnosed colorectal cancers. The usefulness of miRNAs as clinical biomarkers predictive of the outcome and response to chemoradiotherapy has been well-reported for rectal cancer. However, the existing literature on their functional and therapeutic impact needs to be put in context to clarify their role in disease pathogenesis. Therfore, this review is focused on the functional relevance of miRNAs as key regulators of signaling pathways in rectal cancer and their potential therapeutic value as novel molecular targets in this disease.

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miR‐129‐5p inhibits proliferation, migration, and invasion in rectal adenocarcinoma cells through targeting E2F7

Cited by 24 publications

References 46 publications

Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma

Integrated Analysis of lncRNA–Mediated ceRNA Network in Lung Adenocarcinoma

<p>Long Non-Coding RNA <em>PITPNA-AS1</em> Accelerates the Progression of Colorectal Cancer Through <em>miR-129-5p</em>/<em>HMGB1</em> Axis</p>

MicroRNAs in Rectal Cancer: Functional Significance and Promising Therapeutic Value

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