miR-130-CYLD Axis Is Involved in the Necroptosis and Inflammation Induced by Selenium Deficiency in Pig Cerebellum

Jiao, Linfei; He, Zhao; Wang, Shengchen; Sun, Chunli; Xu, Shiwen

doi:10.1007/s12011-021-02612-6

Cited by 6 publications

(2 citation statements)

References 52 publications

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“…Cui et al [118] have shown that selenium deficiency induced necroptosis through the regulation of TNFR1 by miRNA-29a-3p in the pig brain. In another study, selenium deficiency induced the deregulation of the miR-130─CYLD axis and caused RIPK3-dependent necroptosis in the pig cerebellum [119].…”

Section: Central Nervous Systemmentioning

confidence: 95%

Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay

Horváth

Jarabicová

Kura

et al. 2023

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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Section: Central Nervous Systemmentioning

confidence: 95%

Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay

Horváth

Jarabicová

Kura

et al. 2023

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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“…Se deficiency also suppressed miR-130 and miR-29a-3p in pig brain tissue. Decreased miR-130 and miR-29a-3p elevated CYLD and TNFR1 respectively, which facilitated the initiation of necroptosis (84,88). Se deficiency deteriorated LPS-induced necroptosis by upregulating miR-16-5p, which subsequently activated PI3K/AKT pathway in chicken tracheal epithelial cells (85).…”

Section: Selenium and Necroptosismentioning

confidence: 99%

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Zhang

Liu²,

Dai³

et al. 2022

Front. Nutr.

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The discovery of regulated necrosis revitalizes the understanding of necrosis from a passive and accidental cell death to a highly coordinated and genetically regulated cell death routine. Since the emergence of RIPK1 (receptor-interacting protein kinase 1)-RIPK3-MLKL (mixed lineage kinase domain-like) axis-mediated necroptosis, various other forms of regulated necrosis, including ferroptosis and pyroptosis, have been described, which enrich the understanding of pathophysiological nature of diseases and provide novel therapeutics. Micronutrients, vitamins, and minerals, position centrally in metabolism, which are required to maintain cellular homeostasis and functions. A steady supply of micronutrients benefits health, whereas either deficiency or excessive amounts of micronutrients are considered harmful and clinically associated with certain diseases, such as cardiovascular disease and neurodegenerative disease. Recent advance reveals that micronutrients are actively involved in the signaling pathways of regulated necrosis. For example, iron-mediated oxidative stress leads to lipid peroxidation, which triggers ferroptotic cell death in cancer cells. In this review, we illustrate the crosstalk between micronutrients and regulated necrosis, and unravel the important roles of micronutrients in the process of regulated necrosis. Meanwhile, we analyze the perspective mechanism of each micronutrient in regulated necrosis, with a particular focus on reactive oxygen species (ROS).

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The role of hydrogen sulfide in the regulation of necroptosis across various pathological processes

Guo,

Zhang,

Lian

et al. 2024

Mol Cell Biochem

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miR-130-CYLD Axis Is Involved in the Necroptosis and Inflammation Induced by Selenium Deficiency in Pig Cerebellum

Cited by 6 publications

References 52 publications

Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay

Novel, non-conventional pathways of necroptosis in the heart and other organs: Molecular mechanisms, regulation and inter-organelle interplay

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

The role of hydrogen sulfide in the regulation of necroptosis across various pathological processes

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