2020
DOI: 10.3892/mmr.2020.11590
|View full text |Cite
|
Sign up to set email alerts
|

miR‑132 is upregulated in polycystic ovarian syndrome and inhibits granulosa cells viability by targeting Foxa1

Abstract: Polycystic ovary syndrome (PcoS) is one of the most common endocrine metabolic disorders characterized by hyperandrogenism, polycystic ovaries and ovulatory dysfunction. Several studies have suggested that the aberrant expression of micrornas (mirnas/mirs) plays an important role in the pathogenesis of PcoS; however, the role and underlying mechanisms of mir-132 in the development of PcoS remain unclear. in the present study, the expression of mir-132 in granulosa cells (Gcs) derived from 26 patients with PcoS… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2021
2021
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(1 citation statement)
references
References 36 publications
0
1
0
Order By: Relevance
“…Ovarian GCs form gap junctions with oocytes and play an essential role in the growth and development of oocytes [ 32 , 33 ]. Thus, PCOS development has been established as a product of aberrant GC proliferation and apoptosis [ 34 – 36 ]. Notably, miRNAs have critical functions in a myriad of diseases, including PCOS [ 37 ].…”
Section: Discussionmentioning
confidence: 99%
“…Ovarian GCs form gap junctions with oocytes and play an essential role in the growth and development of oocytes [ 32 , 33 ]. Thus, PCOS development has been established as a product of aberrant GC proliferation and apoptosis [ 34 – 36 ]. Notably, miRNAs have critical functions in a myriad of diseases, including PCOS [ 37 ].…”
Section: Discussionmentioning
confidence: 99%