MiR-132 regulated olfactory bulb proteins linked to olfactory learning in greater short-nosed fruit bat Cynopterus sphinx

Mukilan, Murugan; Rajathei, David Mary; Jeyaraj, Edwin; Kayalvizhi, Nagarajan; Rajan, Koilmani Emmanuvel

doi:10.1016/j.gene.2018.05.107

Cited by 9 publications

(12 citation statements)

References 58 publications

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“…Regarding olfaction, miRNAs have been reported to regulate chemosensation in nematodes, invertebrates and vertebrates (Cayirlioglu et al, 2008;Smalheiser et al, 2010;Mukilan et al, 2015Mukilan et al, , 2018Fan et al, 2017;Finger et al, 2019). For example, in mice, the miR-183/96/182 cluster drives the terminal differentiation of multiple sensory receptor cells.…”

Section: Introductionmentioning

confidence: 99%

Characterization and target gene analysis of microRNAs in the antennae of the parasitoid wasp Microplitis mediator

et al. 2020

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MicroRNAs (miRNAs), a class of non-coding single-strand RNA molecules encoded by endogenous genes, are about 21-24 nucleotides long and are involved in the post-transcriptional regulation of gene expression in plants and animals. Generally, the types and quantities of miRNAs in the different tissues of an organism are diverse, and these divergences may be related to their specific functions. Here we have identified 296 known miRNAs and 46 novel miRNAs in the antennae of the parasitoid wasp Microplitis mediator by high-throughput sequencing. Thirty-three miRNAs were predicted to target olfactory-associated genes, including odorant binding proteins (OBPs), chemosensory proteins, odorant receptors (ORs), ionotropic receptors (IRs) and gustatory receptors. Among these, 17 miRNAs were significantly highly expressed in the antennae, four miRNAs were highly expressed both in the antennae and head or wings, while the remaining 12 miRNAs were mainly expressed in the head, thorax, abdomen, legs and wings. Notably, miR-9a-5p and miR-2525-3p were highly expressed in male antennae, whereas miR-1000-5p and novel-miR-13 were enriched in female antennae. The 17 miR-NAs highly expressed in antennae are likely to be associated with olfaction, and were predicted to target one OBP (targeted by miR-3751-3p), one IR (targeted by miR-7-5p) and 14 ORs (targeted by 15 miRNAs including miR-6-3p, miR-9a-5p, miR-9b-5p, miR-29-5p, miR-71-5p, miR-275-3p, miR-1000-5p, miR-1000-3p, miR-2525-3p, miR-6012-3p, miR-9719-3p, novel-miR-10, novel-miR-13, novel-miR-14 and novel-miR-28). These candidate olfactory-associated miRNAs are all likely to be involved in chemoreception through the regulation of chemosensory gene expression in the antennae of M. mediator.

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Section: Introductionmentioning

confidence: 99%

Characterization and target gene analysis of microRNAs in the antennae of the parasitoid wasp Microplitis mediator

et al. 2020

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“…Synthesized 5-HT released into the SC results in the binding with PoSN and activates the CREB-mediated neuronal signaling pathway (CMNSP). Activated CMNSP may further result in the formation of LTM (Mukilan et al 2015;Mukilan et al 2018b;Thangaleela et al 2018;Mukilan 2022;Mukilan 2023).…”

Section: Introductionmentioning

confidence: 99%

Role of Probiotic Strain Lactobacillus acidophilus in the Reversal of Gut Dysbiosis Induced Brain Cognitive Decline

Mukilan,

Antony Mathew,

Yaswanth

et al. 2024

J Exp Bio & Ag Sci

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In the central nervous system, bidirectional communication between the brain and gut results in memory formation due to synaptic plasticity changes. During a healthy state, oral balanced microflora plays a pivotal role in memory formation by inhibiting the enterotoxin level produced by infectious pathogens. In disease conditions, beneficial microbial dysbiosis may result in excess enterotoxin production. Further, excess enterotoxin secretion prevents beneficial bacteria's proliferation and impairs neurotransmitter precursor compounds' transport to the brain. Blockade of neurotransmitter precursor compounds may result in the development of memory loss. The present study stated the role of Lactobacillus acidophilus in recovering memory loss. Reversal of cognitive impairment is shown with the help of a three-step behavioural analysis, which consists of one pre-infusive behavioural analysis and two post-infusive behavioural analyses (phase 1 and 2). The pre-infusive analysis showed no cognitive impairment in an assimilated environment without any infusions. After oral microbial infusions, phase 1 of post-infusive behavioural analysis showed the presence of cognitive impairment in the experimental groups who received oral infusions. Formed cognitive impairment is reverted with the help of L. acidophilus oral infusion in phase 2 of post-infusive analysis. Comparative three-step behavioural analysis proved that Pseudomonas aeuroginosa induced cognitive impairment may revert to normal conditions with the help of L. acidophilus. The outcome of the present study proves that cognitive impairment developed due to poor oral hygiene can be treated with the help of probiotic microorganisms.

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“…The learning process is associated with activity-dependent changes and results in neurotransmitters' release (Lovinger 2010;Bai and Suzuki 2020). Neurotransmitter release results in the activation of neuronal signaling pathway with the help of several proteins like protein kinase A (PKA), extracellular signal-regulated kinase-1/2 (ERK-1/2), mitogen-activated protein kinase (MAPK), and cyclic AMP response element-binding protein-1 (CREB-1) (Yoon and Seger 2006;Ganesh et al 2010;Ganesh et al 2012;Mukilan et al 2015;García-Pardo et al 2016;Mukilan et al 2018aMukilan et al , 2018b. Activation of ERK-1/2 results in the phosphorylation of CREB-1 (Peng et al 2010).…”

Section: Introductionmentioning

confidence: 99%

“…Activation of ERK-1/2 results in the phosphorylation of CREB-1 (Peng et al 2010). Further, phosphorylated CREB-1 results in the activation of the immediate early gene (IEG) cascade and other postsynaptic density protein (PSD), which results in the formation of LTM (Ganesh et al 2010;Ganesh et al 2012;Mukilan et al 2015;Mukilan et al 2018aMukilan et al , 2018b.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Probiotics, Prebiotics and Synbiotic Supplementation on Cognitive Impairment: A Review

Mukilan

2022

J Exp Bio & Ag Sci

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Learning and memory formation are the two essential terms widely used in the field of cognition. Learning can be defined as acquiring new information or skills. Memory is formed due to changes in the neuronal system as a result of continuous stimulus exposure. Both learning and memory are fundamental processes that occur in all living organisms. Memory is broadly categorized into two different categories such as short-term memory (STM) and long-term memory (LTM). Compared to STM, LTM plays an essential role in the day-to-day activities of different living organisms. LTM requires RNA and protein synthesis-dependent mechanisms for memory storage, which lasts up to their lifetime. LTM formation is initiated when the neurotransmitters are released from the presynaptic neuron; further released neurotransmitters bind with their respective receptors present in the postsynaptic neuron and initiate the calcium influx. Calcium influx results in the further activation of molecules involved in the neuronal signaling pathway and results in memory formation. Present review reports the outcome of recent studies which showed that probiotic supplement is responsible for the retrieval of memory in case of memory impairment and its uses in the treatment of neurodegenerative disorders like mild cognitive impairment (MCI), Alzheimer's disease (AD). Recent research studies were shown that probiotic microorganisms may positively regulate neurotransmitter release and increase the calcium influx, brain derived neurotrophic factor (BDNF), and N-methyl-D-aspartate receptor (NMDAR) and plays a pivotal role in the LTM formation in gut-dysbiosed & memory-impaired animal models.

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MiR-132 regulated olfactory bulb proteins linked to olfactory learning in greater short-nosed fruit bat Cynopterus sphinx

Cited by 9 publications

References 58 publications

Characterization and target gene analysis of microRNAs in the antennae of the parasitoid wasp Microplitis mediator

Characterization and target gene analysis of microRNAs in the antennae of the parasitoid wasp Microplitis mediator

Role of Probiotic Strain Lactobacillus acidophilus in the Reversal of Gut Dysbiosis Induced Brain Cognitive Decline

Effects of Probiotics, Prebiotics and Synbiotic Supplementation on Cognitive Impairment: A Review

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