2010
DOI: 10.1038/ncb2054
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miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator

Abstract: MicroRNAs are small, non-coding RNAs that negatively regulate gene expression. It has been proposed that microRNAs could function in the regulation of innate immunity, but this has not been demonstrated for viral infection. Here we test this hypothesis using the human pathogenic virus Kaposi's sarcoma-associated herpesvirus (KSHV) and one of its putative natural cellular targets, primary lymphatic endothelial cells (LECs). We show that an early antiviral microRNA response (6 h post-infection) includes expressi… Show more

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Cited by 311 publications
(298 citation statements)
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“…Although we found that the expression profiles of miR-132 and miR-212 are closely related, miR-132 is the principal partner that attributes to the main effects of miR-212/132 cluster [24]. Importantly, miR-132 is more relevant to the CNS because it is highly expressed in the brain, while the expression of miR-212 is much lower [18].…”
Section: Activation Of Ahr By Tcdd Regulates the Expression Of Mir-21mentioning
confidence: 65%
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“…Although we found that the expression profiles of miR-132 and miR-212 are closely related, miR-132 is the principal partner that attributes to the main effects of miR-212/132 cluster [24]. Importantly, miR-132 is more relevant to the CNS because it is highly expressed in the brain, while the expression of miR-212 is much lower [18].…”
Section: Activation Of Ahr By Tcdd Regulates the Expression Of Mir-21mentioning
confidence: 65%
“…In addition, miR-212 was induced by Treg and Th17 conditions in the absence of TCDD, and Ahr −/− T cells expressed miR-212 at much lower levels. Comparison of miR-132 and miR-212 expression profiles provides the first evidence that TCDD-activated Ahr regulates the transcription of miR-212/132 cluster in the immune compartment.Although we found that the expression profiles of miR-132 and miR-212 are closely related, miR-132 is the principal partner that attributes to the main effects of miR-212/132 cluster [24]. Importantly, miR-132 is more relevant to the CNS because it is highly expressed in the brain, while the expression of miR-212 is much lower [18].…”
mentioning
confidence: 65%
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“…The transcriptional coactivator p300, which often associates with CREB, is targeted by miR-132 in endothelial cells. 59 Additionally, the transcriptional corepressor C/ EBPb is targeted by miR-155 as well. 86 Thus, miRNAs can directly target several transcription factors and control the transcription of TLR-induced genes.…”
Section: Mirnas In Regulation Of Tlr and Rig-i Pathways Yk LI And Xy mentioning
confidence: 99%
“…57 Additionally, miR-132 was demonstrated to be controlled by cyclic AMP response element-binding protein and transcriptional coactivator p300. 58,59 Moreover, miR-21 is induced in an NF-kB-dependent manner at later times in macrophages after LPS treatment. 52 Other miRNAs are also induced after TLR treatment or pathogen infection, including miR-223, miR-147, miR-9, miR-27b and let7e.…”
Section: Introductionmentioning
confidence: 99%