2024
DOI: 10.1186/s13048-023-01328-6
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MiR-134-3p targets HMOX1 to inhibit ferroptosis in granulosa cells of sheep follicles

Gulimire Abudureyimu,
Yangsheng Wu,
Ying Chen
et al.

Abstract: Background The intricate interplay of gene expression within ovarian granulosa cells (GCs) is not fully understood. This study aimed to investigate the miRNA regulatory mechanisms of ferroptosis during the process of follicle development in lamb GCs. Methods Employing transcriptome sequencing, we compared differentially expressed mRNAs (DE-mRNAs) and miRNAs (DE-miRNAs) in GCs from lambs treated with follicle-stimulating hormone (FL) to untreated co… Show more

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Cited by 2 publications
(2 citation statements)
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“…For example, lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis [27]. Furthermore, MiR-134-3p targets HMOX1 to inhibit ferroptosis in granulosa cells of sheep follicles [29]. In this study, regulating the expression of circAMN1 or miR-205_R-1 changed the migration ability of trophoblast cells.…”
Section: Discussionmentioning
confidence: 56%
See 1 more Smart Citation
“…For example, lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis [27]. Furthermore, MiR-134-3p targets HMOX1 to inhibit ferroptosis in granulosa cells of sheep follicles [29]. In this study, regulating the expression of circAMN1 or miR-205_R-1 changed the migration ability of trophoblast cells.…”
Section: Discussionmentioning
confidence: 56%
“…The non-coding RNAs (ncRNAs) play vital roles in various forms of PCD [27][28][29]. For example, lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis [27].…”
Section: Discussionmentioning
confidence: 99%