MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel

Zhang, Heda; Sun, Dawei; Mao, Ling; Zhang, Jun; Jiang, Linhong; Li, Jian; Wu, Ying; Jiang, Hao; Chen, Wei; Wang, Jing; Ma, Rong; H, Cao; Wu, Jianzhong; Tang, Jinhai

doi:10.1016/j.bbrc.2015.08.053

Cited by 88 publications

(61 citation statements)

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“…It has also been reported that miR-139 can suppress glioblastoma cell proliferation, migration and invasion, and induce apoptosis (25,26). In non-small cell lung cancer, miR-139 decreases the proliferation and invasion of cancer cells (18). Additionally, miR-139 suppresses epithelial-mesenchymal transition, migration and invasion in hepatocellular carcinoma, and the incidence and severity of pulmonary metastasis in orthotopic liver tumors in mice is also reduced (20,27).…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA‑139 inhibits the proliferation, migration and invasion of gastric cancer cells by directly targeting ρ‑associated protein kinase 1

et al. 2018

Oncol Lett

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Abstract. The expression, function and underlying mechanisms of microRNA-139 (miR-139) in gastric cancer were investigated in the present study. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was performed to detect miR-139 expression in gastric cancer tissues and cell lines. The effects of miR-139 overexpression on gastric cancer cell proliferation, migration and invasion were evaluated. ρ-associated protein kinase 1 (ROCK1) was predicted as a downstream target of miR-139 and its role in gastric cancer was assessed by bioinformatics analysis, luciferase reporter assay, RT-qPCR and western blot analysis. ROCK1 overexpression was established to investigate if the effects of miR-139 on gastric cancer cells may be attenuated. The results indicated that miR-139 was aberrantly downregulated in gastric cancer tissues and cell lines. Increased miR-139 expression reduced gastric cancer cell proliferation, migration and invasion. ROCK1 was demonstrated to be a direct target of miR-139 in gastric cancer and ROCK1 overexpression reversed the suppressive effects on gastric cancer cell proliferation, migration and invasion induced by miR-139 overexpression. The present study provides clear evidence demonstrating the anti-oncogenic activity of miR-139 in human gastric cancer, as mediated by the targeted downregulation of ROCK1.

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Section: Discussionmentioning

confidence: 99%

“…Recent studies have revealed that low miR-139 expression occurs in various types of human cancer, including glioma (16), tongue squamous cell carcinoma (17), breast cancer (18), non-small cell lung cancer (19) and colon cancer (20). Furthermore, miR-139 expression has been demonstrated to associate with clinicopathological factors.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑139 inhibits the proliferation, migration and invasion of gastric cancer cells by directly targeting ρ‑associated protein kinase 1

et al. 2018

Oncol Lett

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“…Xu et al exhibited that miR-139-5p functioned as a tumor suppressor by targeting insulin-like growth factor 1 receptor in human non-small cell lung cancer [33]. Zhang et al found that miR-139-5p inhibited the viability, invasion and migration of breast cancer cells by targeting notch1 [34]. The function of a given miRNA is determined by the relative availability of the downstream target mRNAs, as such the same miRNA could have a dual role in different tissues, specifically cancers of different cellular origin [35].…”

Section: Discussionmentioning

confidence: 99%

MiR-139-5p is Increased in the Peripheral Blood of Patients with Prostate Cancer

Pang

Liu²,

Fang³

et al. 2016

Cell Physiol Biochem

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Background: Emerging evidence suggested that microRNAs (miRNAs) play a causal role in cancer tumorigenesis. Aberrant expression of miRNA (miR)-139-5p has been observed in various types of cancers. The present study evaluated the relationship between miR-139-5p expression levels and prostate cancer (PCa), to assess the feasibility of using peripheral blood miR-139-5p as a potential non-invasive biomarker for PCa. Methods: Total RNA was extracted from peripheral whole blood samples from 45 PCa patients, 45 benign prostatic hyperplasia (BPH) patients and 50 healthy controls (HC). The expression of miR-139-5p was assessed by reverse transcription quantitative polymerase chain reaction. Results: MiR-139-5p in peripheral blood was significantly higher in PCa patients than in patients with BPH and HC individuals (P<0.001). Higher miR-139-5p expression was observed to be associated with certain clinicopathological parameters, including PSA>20ng/ml (P<0.05), pathological tumor stage 3/4 (P<0.05) and Gleason score >7 (P<0.01). A receiver operating characteristic (ROC) curve analysis revealed that miR-139-5p distinguished PCa patients from BPH patients [area under the curve (AUC), 0.936; 95% CI, 0.878-0.993; P<0.001]. Conclusions: Peripheral blood miR-139-5p may be utilized as a potential novel non-invasive biomarker for PCa screening.

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“…[3][4][5] MiRNAs modulate messenger RNAs (mRNAs) translation through canonical base pairing between the seed sequence (nucleotides 2-8) of the miRNAs and the complementary seed match sequences of target mRNAs, which are typically located in the 3′ untranslated region (3′UTR). Interaction between miRNAs and mRNAs is not specific, that is, every miRNA can target multiple mRNAs, and correspondingly each mRNA can be regulated by a great deal of miRNAs.…”

Section: Introductionmentioning

confidence: 99%

Promising therapeutic role of miR-27b in tumor

Ding

Yang

et al. 2017

Tumour Biol.

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MicroRNAs are small nonprotein-encoding RNAs ranging from 18 to 25 nucleotides in size and regulate multiple biological pathways via directly targeting a variety of associated genes in cancers. MicroRNA-27b is a highly conserved MicroRNA throughout vertebrates and there are two homologs (hsa-miR-27a and hsa-miR-27b) in humans. MicroRNA27b is an intragenic microRNA located on chromosome 9q22.1 within the C9orf3 gene, clustering with miR-23b and miR-24-1 in human. As a frequently dysregulated microRNA in human cancers, microRNA-27b could function as a tumor suppressor or an oncogenic microRNA. More and more studies indicate that microRNA-27b is involved in affecting various biological processes, such as angiogenesis, proliferation, metastasis, and drug resistance, and thus may act as a promising therapeutic target in human cancers. In this review, we discuss the role of microRNA-27b in detail and offer novel insights into molecular targeting therapy for cancers.

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MiR-139-5p inhibits the biological function of breast cancer cells by targeting Notch1 and mediates chemosensitivity to docetaxel

Cited by 88 publications

References 50 publications

MicroRNA‑139 inhibits the proliferation, migration and invasion of gastric cancer cells by directly targeting ρ‑associated protein kinase 1

MicroRNA‑139 inhibits the proliferation, migration and invasion of gastric cancer cells by directly targeting ρ‑associated protein kinase 1

MiR-139-5p is Increased in the Peripheral Blood of Patients with Prostate Cancer

Promising therapeutic role of miR-27b in tumor

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