miR-140-5p and miR-140-3p: Key Actors in Aging-Related Diseases?

Toury, Léa; Frankel, Diane; Airault, Coraline; Magdinier, Frédérique; Roll, Patrice; Kaspi, Elise

doi:10.3390/ijms231911439

Cited by 10 publications

(5 citation statements)

References 107 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To test whether the 68 putative NF-kB responsive miRNAs could have a biological value in the context of the previous evidence, we compared our results with those already present in the literature. Among these 68 miRNAs, 21 have been experimentally validated to be transcribed by NF-kB1: miR-16-2 [ 75 ], miR-10a [ 76 ], miR-140-3p, miR-140-5p [ 77 ], miR-148b [ 78 ], miR-15b [ 79 ], miR-186 [ 80 ], miR-146a, miR-155, miR-19b, miR-20a, miR-19a, miR-17, miR-221, miR-222, miR-18a, miR-92a, miR-101, miR-23a, miR-27a, and miR-30c [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

A Data-Mining Approach to Identify NF-kB-Responsive microRNAs in Tissues Involved in Inflammatory Processes: Potential Relevance in Age-Related Diseases

Micolucci

Matacchione

Albertini

et al. 2023

IJMS

View full text Add to dashboard Cite

The nuclear factor NF-kB is the master transcription factor in the inflammatory process by modulating the expression of pro-inflammatory genes. However, an additional level of complexity is the ability to promote the transcriptional activation of post-transcriptional modulators of gene expression as non-coding RNA (i.e., miRNAs). While NF-kB’s role in inflammation-associated gene expression has been extensively investigated, the interplay between NF-kB and genes coding for miRNAs still deserves investigation. To identify miRNAs with potential NF-kB binding sites in their transcription start site, we predicted miRNA promoters by an in silico analysis using the PROmiRNA software, which allowed us to score the genomic region’s propensity to be miRNA cis-regulatory elements. A list of 722 human miRNAs was generated, of which 399 were expressed in at least one tissue involved in the inflammatory processes. The selection of “high-confidence” hairpins in miRbase identified 68 mature miRNAs, most of them previously identified as inflammamiRs. The identification of targeted pathways/diseases highlighted their involvement in the most common age-related diseases. Overall, our results reinforce the hypothesis that persistent activation of NF-kB could unbalance the transcription of specific inflammamiRNAs. The identification of such miRNAs could be of diagnostic/prognostic/therapeutic relevance for the most common inflammatory-related and age-related diseases.

show abstract

Section: Resultsmentioning

confidence: 99%

A Data-Mining Approach to Identify NF-kB-Responsive microRNAs in Tissues Involved in Inflammatory Processes: Potential Relevance in Age-Related Diseases

Micolucci

Matacchione

Albertini

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…In this study, compared to HCs, AIS patients showed significantly lower levels of miR‐140‐3p and miR‐320b and higher levels of miR‐130a‐3p in their plasma upon admission. MiR‐140‐3p, located on chromosome 16q22.1, is hosted in the 15th intron of the human WW domain containing E3 Ubiquitin protein ligase 2 ( WWP2 ) gene, 14 which has been strongly associated with cardiovascular diseases 15 . It has also been proposed as a plasmatic biomarker for several diseases, 16,17 including mild cognitive impairment 18 .…”

Section: Discussionmentioning

confidence: 99%

The expression levels of circulating miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in acute ischemic stroke

Ju,

Tang,

et al. 2023

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Plasma miRNAs can characterize several diseases, including acute ischemic stroke (AIS), which is noninvasive and currently affordable in most laboratories worldwide. We aimed to demonstrate plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in AIS.GSE110993 and GSE86291 datasets were analyzed to obtain plasma differentially expressed miRNAs between AIS and healthy control subjects (HCs). We further applied RT‐qPCR for the validation in 85 AIS patients and 85 HCs. Receiver operating characteristic (ROC) curve were conducted to evaluate their diagnostic utility in AIS. Correlation was analyzed between DEmiRNAs and clinical and laboratory parameters, as well as inflammatory markers. The plasma levels of miR‐140‐3p, miR‐130a‐3p, and miR‐320b were found to be consistently altered in both GSE110993 and GSE86291 datasets. In comparison to HCs, AIS patients at admission exhibited lower levels of miR‐140‐3p and miR‐320b and higher level of miR‐130a‐3p in their plasma. The ROC analysis revealed that plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b had area under the curve values of 0.790, 0.831, and 0.907, respectively. When combined, these miRNAs showed superior discriminatory power with a sensitivity of 91.76% and specificity of 95.29%. Plasma miR‐140‐3p and miR‐320b negatively correlated glucose levels and inflammatory markers (IL‐6, MMP‐2, MMP‐9, and VEGF) in AIS patients. Conversely, plasma miR‐130a‐3p levels were positively associated with glucose levels and these markers. Plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b levels varied significantly among AIS patients with different NIHSS scores. Plasma miR‐140‐3p, miR‐130a‐3p, and miR‐320b had high diagnostic value in AIS patients, which were correlated with inflammation and severity in stroke.

show abstract

“…The miR-140 gene encodes pre-miR-140, giving rise to two mature miRNAs, miR-140-5p and miR-140-3p. Located on chromosome 16q22.1, this gene resides within the 15th intron of the WW domain containing E3 ubiquitin protein ligase 2 (WWP2) human gene ( Toury et al, 2022 ). Notably, miR-140-5p exhibits specific expression in cartilage ( Tuddenham et al, 2006 ).…”

Section: Survey Methodologymentioning

confidence: 99%

The role of CEMIP in cancers and its transcriptional and post-transcriptional regulation

Guo,

Chen

et al. 2024

PeerJ

View full text Add to dashboard Cite

CEMIP is a protein known for inducing cell migration and binding to hyaluronic acid. Functioning as a hyaluronidase, CEMIP primarily facilitates the breakdown of the extracellular matrix component, hyaluronic acid, thereby regulating various signaling pathways. Recent evidence has highlighted the significant role of CEMIP in different cancers, associating it with diverse pathological states. While identified as a biomarker for several diseases, CEMIP’s mechanism in cancer seems distinct. Accumulating data suggests that CEMIP expression is triggered by chemical modifications to itself and other influencing factors. Transcriptionally, chemical alterations to the CEMIP promoter and involvement of transcription factors such as AP-1, HIF, and NF-κB regulate CEMIP levels. Similarly, specific miRNAs have been found to post-transcriptionally regulate CEMIP. This review provides a comprehensive summary of CEMIP’s role in various cancers and explores how both transcriptional and post-transcriptional mechanisms control its expression.

show abstract

miR-140-5p and miR-140-3p: Key Actors in Aging-Related Diseases?

Cited by 10 publications

References 107 publications

A Data-Mining Approach to Identify NF-kB-Responsive microRNAs in Tissues Involved in Inflammatory Processes: Potential Relevance in Age-Related Diseases

A Data-Mining Approach to Identify NF-kB-Responsive microRNAs in Tissues Involved in Inflammatory Processes: Potential Relevance in Age-Related Diseases

The expression levels of circulating miR‐140‐3p, miR‐130a‐3p, and miR‐320b as diagnostic biomarkers in acute ischemic stroke

The role of CEMIP in cancers and its transcriptional and post-transcriptional regulation

Contact Info

Product

Resources

About