miR-143 regulates proliferation and differentiation of bovine skeletal muscle satellite cells by targeting IGFBP5

Zhang, Wei Ran; Zhang, Hui Na; Wang, Yi Min; Dai, Yang; Liu, Xin Feng; Li, Xin; Xiang, Dongxi; Guo, Hong

doi:10.1007/s11626-016-0109-y

Cited by 50 publications

(30 citation statements)

References 31 publications

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“…In mouse mammary gland, IGFBP-5 expression is suppressed by the hormone prolactin and STAT-3 (32,36,37). IGFBP-5 mRNA has also been found to be regulated by several miRNAs (37)(38)(39)(40).…”

Section: Expression and Regulationmentioning

confidence: 99%

Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease

Duan

Allard

2020

Front. Endocrinol.

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Insulin-like growth factor (IGF) signaling is regulated by a conserved family of IGF binding proteins (IGFBPs) in vertebrates. Among the six distinct types of IGFBPs, IGFBP-5 is the most highly conserved across species and has the broadest range of biological activities. IGFBP-5 is expressed in diverse cell types, and its expression level is regulated by a variety of signaling pathways in different contexts. IGFBP-5 can exert a range of biological actions including prolonging the half-life of IGFs in the circulation, inhibition of IGF signaling by competing with the IGF-1 receptor for ligand binding, concentrating IGFs in certain cells and tissues, and potentiation of IGF signaling by delivery of IGFs to the IGF-1 receptor. IGFBP-5 also has IGF-independent activities and is even detected in the nucleus. Its broad biological activities make IGFBP-5 an excellent representative for understanding IGFBP functions. Despite its evolutionary conservation and numerous biological activities, knockout of IGFBP-5 in mice produced only a negligible phenotype. Recent research has begun to explain this paradox by demonstrating cell type-specific and physiological/pathological context-dependent roles for IGFBP-5. In this review, we survey and discuss what is currently known about IGFBP-5 in normal physiology and human disease. Based on recent in vivo genetic evidence, we suggest that IGFBP-5 is a multifunctional protein with the ability to act as a molecular switch to conditionally regulate IGF signaling.

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Section: Expression and Regulationmentioning

confidence: 99%

Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease

Duan

Allard

2020

Front. Endocrinol.

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“…IGFBP5, an inhibitory binding protein with affinity for IGF, is highly upregulated in nerve biopsies of patients with diabetic neuropathy. Zhang WR et al have showed that miR-143 regulates proliferation and differentiation of bovine skeletal muscle satellite cells by targeting IGFBP5, 36 miR-143 also directly regulates the expression of IGFBP5 during muscle regeneration. 37 No mechanism of action or function of IGFBP5 in insulin signaling and MetS patients was elucidated.…”

Section: Discussionmentioning

confidence: 99%

Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor

Lin

Shengjie

Gui

et al. 2019

Translational Research

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Metabolic syndrome (MetS) is characterized by a cluster of metabolic disorders including obesity, dyslipidemia, hyperglycemia, and hypertension. Here, we report that 27 microRNAs were found to be expressed differently in serum and urine samples of MetS patients compared to control subjects on microarray analysis. Further qualitative real time-polymerase chain reaction analyses confirmed that circulating levels of miR-143-3p were significantly elevated in MetS patients compared with controls, both in serum and urine samples. After accounting for confounding factors, high levels of miR-143-3p remained an independent risk factor for insulin resistance. Inhibition of miR-143-3p expression in mice protected against development of obesity-associated insulin resistance. Furthermore, we demonstrated that insulin-like growth factor 2 receptor (IGF2R) was among the target genes of miR-143-3p by searching 3 widely used bioinformatics databases and preliminary validation. Our experiments suggest that knockdown of circulating miR-143-3p may protect against insulin resistance in the setting of MetS via targeting of IGF2R and activation of the insulin signaling pathway. Our results characterize the miR-143-3p-IGF2R pathway as a potential target for the treatment of obesity-associated insulin resistance.

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“…This then allows the binding proteins to influence IGFs, either by altering IGF actions or by switching on IGF‐II . The regulation of IGFBP‐5 is more elusive but studies point to regulation by key microRNAs like miR‐140 …”

Section: Discussionmentioning

confidence: 99%

Upregulation of Systemic Inflammatory Pathways Following Anterior Cruciate Ligament Injury Relates to Both Cartilage and Muscular Changes: A Pilot Study

Hunt

Villasanta‐Tezanos

Butterfield

et al. 2019

Journal Orthopaedic Research

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In conjunction with cartilage breakdown, muscle maladaptation including atrophy and increased fibrosis have been observed in the quadriceps following anterior cruciate ligament (ACL) injury. Previously observed upregulated muscle-related proteins in the synovial fluid following ACL rupture allude to cellular communication between the joint and muscle. Therefore, the purpose of this study was to determine whether muscle-related analytes are differentially expressed in the serum. Sixteen patients with an acute ACL tear participated in this IRB-approved study. Serum was obtained at two different time points at a mean of 6 and 14 days post-injury, and serum was analyzed by a highly multiplexed assay of 1,300 proteins. Pathway analysis using DAVID was performed; genes included met three criteria: significant change between the two study time points using a paired t test, significant change between the two study time points using a Mann-Whitney non-parametric test, and significant Benjamini post hoc analysis. Twelve analytes significantly increased between time points. Proteins chitinase-3-like protein 1 (p = 0.01), insulin-like growth factor binding protein 1 (p = 0.01), insulin-like growth factor binding protein 5 (p = 0.02), renin (p = 0.004), and lymphotoxin alpha 1: beta 2 (p = 0.03) were significantly upregulated in serum following acute ACL injury. The current results confirm the inflammatory pattern previously seen in the synovial fluid thought to play a role in the progression of post-traumatic osteoarthritis after ACL injury, and this data also provides further insights into important communication between the joint and quadriceps group, whose function is important in long term health.

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miR-143 regulates proliferation and differentiation of bovine skeletal muscle satellite cells by targeting IGFBP5

Cited by 50 publications

References 31 publications

Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease

Insulin-Like Growth Factor Binding Protein-5 in Physiology and Disease

Circulating miR-143-3p inhibition protects against insulin resistance in Metabolic Syndrome via targeting of the insulin-like growth factor 2 receptor

Upregulation of Systemic Inflammatory Pathways Following Anterior Cruciate Ligament Injury Relates to Both Cartilage and Muscular Changes: A Pilot Study

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