miR-146a Overexpression in Oral Squamous Cell Carcinoma Potentiates Cancer Cell Migration and Invasion Possibly via Targeting HTT

Wang, Liping; Chen, Yunxin; Yan, Yongyong; Guo, Xueqi; Fāng, Yīng; Su, Yu-Cheng; Wang, Lijing; Pathak, Janak L.; Ge, Linhu

doi:10.3389/fonc.2020.585976

Cited by 13 publications

(6 citation statements)

References 39 publications

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“…These results show that the influence of dysregulated miRNA levels upon the tumor microenvironment contributes to the development and migration of the malignant cells. Nevertheless, the altered expressions of different miRNAs have been also linked to several other malignancies such as colon cancer [ 123 , 124 ], lung cancer [ 125 ], ovarian and breast cancer [ 126 , 127 ], oral cancer, and the evolution of carcinogenesis [ 128 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy

et al. 2023

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Oral cancer is currently challenging the healthcare system, with a high incidence among the population and a poor survival rate. One of the main focuses related to this malignancy is the urge to implement a viable approach for improving its early diagnosis. By introducing the use of liquid biopsy and the identification of potential biomarkers, aiming for a noninvasive approach, new advancements offer promising perspectives in the diagnosis of oral cancer. The present review discusses the potential of circulating miRNAs as oral cancer biomarkers identified in body fluids such as serum, plasma, and saliva samples of oral cancer patients. Existing results reveal an important implication of different miRNA expressions involved in the initiation, development, progression, and metastasis rate of oral malignancy. Liquid biomarkers can play a crucial role in the development of the concept of personalized medicine, providing a wide range of clinical applications and future targeted therapies.

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Section: Discussionmentioning

confidence: 99%

Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy

et al. 2023

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“…Liu et al reported miR-31 as a potential tool for diagnosing precancerous lesions, as it is more abundant in the saliva of OSCC patients [ 40 ]. Several miRNAs (miR-372, miR-134, miR-146a) were associated with metastasis [ 41 ]. The overexpression of miR-146 mediated OSCC cell migration and invasion and increased metastasis by downregulating the expression of IRAK1, TRAF6 and NUMB [ 42 ].…”

Section: Liquid Biopsy: Kill Two Birds With One Stonementioning

confidence: 99%

MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis

Bocchetti

Grisolia

Melisi

et al. 2022

Cancers

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Salivary gland cancer (SGC) is an uncommon and heterogeneous disease that accounts for around 8.5% of all head and neck cancers. MicroRNAs (miRNAs) consist of a class of highly conserved, short, single-stranded segments (18–25 nucleotides) of noncoding RNA that represent key gene-transcription regulators in physiological and pathological human conditions. However, their role in SGC development and progression is not completely clear. This review aims to compile and summarize the recent findings on the topic, focusing on the prognostic and diagnostic value of the major modulated and validated microRNAs in SGC. Their differential expression could possibly aid the clinician in delivering an early diagnosis, therapeutic strategy and precision medicine.

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“…After 7 days of irradiation, the mice were euthanized by exsanguination prior after intraperitoneal anesthesia. The tongue tissues were immediately cut out and xed in 4% formaldehyde solution, embedded in para n and sectioned [12].…”

Section: Animal Experimentsmentioning

confidence: 99%

miR-199b-3p Promotes Radiation-induced Oral Mucositis via DDIT4-mediated mTOR Signal Pathway

Yang

Zeng

et al. 2021

Preprint

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Background: Radiation-induced oral mucositis (RIOM) is an adverse reaction in patients of head and neck cancer after radiotherapy. However, the key regulatory factors in the pathogenesis of RIOM remain largely unclear. In this article, we discover a novel role of DNA damage-inducible transcript 4 (DDIT4) in regulating RIOM pathogenesis.Methods: We established RIOM in vitro and in vivo models to mimic the biological processes of RIOM. The level of DDIT4 in RIOM was analyzed by real-time PCR and Western blot. Through the bioinformatics analysis and luciferase assay, the relationship between miR-199b-3p and DDIT4 was performed. The level of mTOR signaling were explored by Western blot. Besides, Clone Formation and EDU assay were performed to investigate the effects of miR-199b-3p/DDIT4 on cell proliferation. H&E and immunohistochemistry experiments examined the effects of miR-199b-3p/DDIT4 on RIOM in vivo. Results: We found that the level of DDIT4 was significantly reduced during the RIOM formation, and up-regulated of DDIT4 suppressed the progression of RIOM in vitro and in vivo. Besides, we found DDIT4 was a direct target of miR-199b-3p. Ectopic expression of miR-199b-3p repressed the level of DDIT4 and activated mTOR signal conduction to promote RIOM progress, whereas the silencing of miR-199b-3p promoted the DDIT4-mediated RIOM regulation both in vitro and in vivo. Conclusion: Collectively, our studies not only identified the novel functional role of DDIT4 in modulating pathogenic processes of RIOM but also provided new directions and ideas for the future treatment of radiotherapy oral mucositis.

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miR-146a Overexpression in Oral Squamous Cell Carcinoma Potentiates Cancer Cell Migration and Invasion Possibly via Targeting HTT

Cited by 13 publications

References 39 publications

Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy

Circulating miRNA as a Biomarker in Oral Cancer Liquid Biopsy

MicroRNAs’ Crucial Role in Salivary Gland Cancers’ Onset and Prognosis

miR-199b-3p Promotes Radiation-induced Oral Mucositis via DDIT4-mediated mTOR Signal Pathway

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