miR-149 promotes human osteocarcinoma progression via targeting bone morphogenetic protein 9 (BMP9)

Xie, Z.; Xu, Jing; Peng, Libo; Gao, Yi; Zhao, Hong; Qu, Youxing

doi:10.1007/s10529-017-2445-8

Cited by 13 publications

(8 citation statements)

References 12 publications

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“…Besides, miR‐346 was significantly expressed in the frontal bone versus parietal bone, and miR‐346 was reported to positively regulate osteogenic differentiation by targeting on GSK‐3β to activate Wnt/β‐catenin pathway . The identified miR‐149 in this study was also reported to target on BMP‐9 to promote OS progression . Furthermore, SMOC1 and (Tnn) were found to be involved in osteoblast differentiation, and Tnn was able to stimulate osteoblastic differentiation, and the endogenous Tnn can maintain the functional state of cultured osteoblast‐like cells.…”

Section: Discussionmentioning

confidence: 60%

“…44 The identified miR-149 in this study was also reported to target on BMP-9 to promote OS progression. 45 Furthermore, SMOC1 46,47 and (Tnn) 48 were found to be involved in osteoblast differentiation, and Tnn was able to stimulate osteoblastic differentiation, and the endogenous Tnn can maintain the functional state of cultured osteoblast-like cells. SMOC1 and Tnn were found highly expressed in the parietal bone rather than in the frontal bone.…”

Section: T a B L E 1 Predicted Target Gene Of Differentially Expressementioning

confidence: 99%

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Regional difference in microRNA regulation in the skull vault

Chen

Yao

et al. 2019

Developmental Dynamics

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Background The murine calvaria has several membrane bones with different tissue origins (e.g., neural crest‐derived frontal bone vs. mesoderm‐derived parietal bone). Neural crest‐derived frontal bone exhibits superior osteogenic activities and bone regeneration. MicroRNA (miRNA) has been emerged as a crucial regulator during organogenesis and is involved in a range of developmental processes. However, the underlying roles of miRNA regulation in frontal bone and parietal bone is unknown. Results Total of 83 significantly expressed known miRNAs were identified in frontal bones versus parietal bones. The significantly enriched gene ontology and KEGG pathway that were predicted by the enrichment miRNAs were involved in several biological processes (cell differentiation, cell adhesion, and transcription), and multiple osteogenic pathways (e.g., focal adhesion, MAPK, VEGF, Wnt, and insulin signaling pathway. Focal adhesion and insulin signaling pathway were selected for target verification and functional analysis, and several genes were predicted to be targets genes by the differentially expressed miRNAs, and these targets genes were tested with significant expressions. Conclusions Our results revealed a novel pattern of miRNAs in murine calvaria with dual tissue origins, and explorations of these miRNAs will be valuable for the translational studies to enhance osteogenic potential and bone regeneration in the clinic.

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Section: Discussionmentioning

confidence: 60%

Section: T a B L E 1 Predicted Target Gene Of Differentially Expressementioning

confidence: 99%

Regional difference in microRNA regulation in the skull vault

Chen

Yao

et al. 2019

Developmental Dynamics

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“…In contrast, overexpression of PTN also weakened the inhibitory effect of miRNA-137-3p on the proliferation of drug-resistant OS cells. MiRNA-149 is a cancer-promoting factor, 25 and its expression is significantly increased in the OS tissues. It is negatively correlated with the target gene bone morphogenetic protein 9 (BMP9) and affects the expression of Caspase3 and PARP.…”

Section: The Role Of Mirna In Adriamycin Resistancementioning

confidence: 99%

Research Progress of MicroRNA in Chemotherapy Resistance of Osteosarcoma

Tang

Chen

et al. 2021

Technol Cancer Res Treat

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Osteosarcoma (OS) is a malignant tumor prevalent in adolescents; however, a clinically effective treatment for this malignancy is lacking. The lack of effective treatment methods and factors, such as recurrence and drug resistance, further dampen the prospect of clinically treating OS. In recent years, small molecule microRNAs (miRNAs) with a length of approximately 20-24 nucleotides have gradually attracted the attention of the medical community. Studies have found that miRNAs can regulate the cell cycle, apoptosis, cell proliferation, and cell proliferation. The metabolic response of cancer cells, invasion and metastasis of cancer cells, and angiogenesis play an important role in the process of tumorigenesis. miRNAs regulate gene expression by regulating mRNA expression after transcription. A large amount of data from many studies indicate that they have diagnostic and prognostic biomarker effects in OS and are involved in regulating the metabolism of cancer cells and resistance or sensitivity to chemotherapy drugs. Chemotherapy resistance is one of the most critical problems in clinically treating OS. A large number of basic studies and systematic summaries are required to provide a theoretical basis for elucidating the mechanism and drug development of chemotherapeutic agents. Therefore, this article discusses the role of miRNAs in OS resistance. Herein, the related research progress of the studies is reviewed to provide more useful information for the development of effective therapy.

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“…To our surprise, miR‐149‐3p induces apoptosis by repressing v‐akt murine thymoma viral oncogene homologue 1 (AKT1) and E2F transcription factor 1 (E2F1) expression in neuroblastoma and HeLa cells . A novel study showed that in osteocarcinoma (OS) patients, upregulation of miR‐149‐5p and the resultant downregulation of its target bone morphogenetic protein 9 (BMP9) inhibit apoptosis and then promote the progression of OS …”

Section: Mir‐149's Roles and Functions In Different Cancersmentioning

confidence: 99%

Regulation and functions of MicroRNA‐149 in human cancers

et al. 2018

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MicroRNAs are small non-coding RNAs that play critical roles in the regulatory mechanisms involving cell differentiation, proliferation, apoptosis and tumorigenesis. Recent research efforts have been conducted to apply these discoveries into clinical functions, including the early diagnosis and therapeutic outcome of patients with cancer. Previous studies have shown that microRNA-149 (miR-149) is dysregulated in various human cancers and exerts its effects on tumorigenesis and tumour progression. In this review, we summarized the potential roles of miR-149 dysregulation and its target genes during tumorigenesis and clinical treatment of human cancers.

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miR-149 promotes human osteocarcinoma progression via targeting bone morphogenetic protein 9 (BMP9)

Abstract: miR-149 promotes OS progression via targeting BMP9.

Cited by 13 publications

References 12 publications

Regional difference in microRNA regulation in the skull vault

Regional difference in microRNA regulation in the skull vault

Research Progress of MicroRNA in Chemotherapy Resistance of Osteosarcoma

Regulation and functions of MicroRNA‐149 in human cancers

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