miR-153 as biomarker for cancer—functional role as tumor suppressor

Abstract

, belongs to a class of small non-coding RNA. It is a critical regulator of gene expression at the post-transcriptional level which interacts with the functional mRNA at 3'UTR region and suppresses the expression of the mRNA. More recently, it has become apparent that changes in the miR-153 expression lead to invasion, metastasis, angiogenesis and various types of tumor progression. This review summarizes the connection between dysregulation of miR-153 and various types of cancer progression. miR-153 regulates various signaling pathways to inhibit the proliferation and induce apoptosis in the cancer cell and also show synergistic activity with anticancer drugs. In addition to this, the oncogenic behavior of miR-153 and their use as a potential biomarker in cancer was also reviewed.

CCND2 and miR-206 as potential biomarkers in the clinical diagnosis of thyroid carcinoma by fine-needle aspiration cytology

“…miRNA is single-stranded RNA molecule with a length of 20–23 nucleotides (nt) and is an important regulator of gene expression, including the genes that mediate tumorigenesis [ 13 ]. Recent studies suggest that miRNAs could be novel biomarkers for cancer [ 14 , 15 ].…”

“…miRNA is single-stranded RNA molecule with a length of 20-23 nucleotides (nt) and is an important regulator of gene expression, including the genes that mediate tumorigenesis [13]. Recent studies suggest that miRNAs could be novel biomarkers for cancer [14,15]. CCND2 is a member of cyclin family and plays a pivotal role in controlling cell cycle transition from G1 phase to S phase.…”

Chitosan-PEI passivated carbon dots for plasmid DNA and miRNA-153 delivery in cancer cells

“…Various studies support the data that miR-153 is downregulated in breast cancer cells (MDA-MB-231) [ 32 , 33 ] and lung cancer cells, and tissues (A549, H460, H157) [ 34 , 35 ]. MiR-153 can also be used as a potential diagnostic biomarker to diagnose distinct types of cancer [ 36 ]. Therefore, the ability of CDs to transfect miRNA was examined in A549 and MDA-MB-231 cells.…”

Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics

“…Furthermore, abnormal expression of certain miRNAs was demonstrated to be linked with a vast number of pathogenesis [ [137] , [138] , [139] ]. Substantiate investigation has also revealed the impact of key transcription factors and signaling pathways on miRNA expression under various physiologic and pathophysiologic conditions [ [140] , [141] , [142] ]. Moreover, different miRNA was reported to control numerous genes at the post-transcriptional stages.…”