2023
DOI: 10.1007/s12035-023-03280-4
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MiR-17-5p Mediates the Effects of ACE2-Enriched Endothelial Progenitor Cell-Derived Exosomes on Ameliorating Cerebral Ischemic Injury in Aged Mice

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Cited by 12 publications
(8 citation statements)
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“…Interventions can alter the expression levels and enhance the functions of miRNAs in EPC-EXOs. ACE-overexpressing EPC-EXOs (ACE-EPC-EXOs) inhibit cellular senescence, EC oxidative stress, apoptosis, and dysfunction, thereby improving brain neurovascular injury in elderly mice with ischemic stroke, through the activation of the miR-17-5p/PTEN/PI3K/Akt signaling pathway [ 103 ]. Additionally, ACE-EPCs-EXOs downregulate Nox2/ROS through miR-18a to alleviate H/R injury in senescent ECs [ 104 ].…”
Section: Contents Of Epc-evsmentioning
confidence: 99%
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“…Interventions can alter the expression levels and enhance the functions of miRNAs in EPC-EXOs. ACE-overexpressing EPC-EXOs (ACE-EPC-EXOs) inhibit cellular senescence, EC oxidative stress, apoptosis, and dysfunction, thereby improving brain neurovascular injury in elderly mice with ischemic stroke, through the activation of the miR-17-5p/PTEN/PI3K/Akt signaling pathway [ 103 ]. Additionally, ACE-EPCs-EXOs downregulate Nox2/ROS through miR-18a to alleviate H/R injury in senescent ECs [ 104 ].…”
Section: Contents Of Epc-evsmentioning
confidence: 99%
“…In summary, EPC-EXOs that overexpress ACE have shown to inhibit cellular senescence, oxidative stress, apoptosis, and dysfunction in ECs, while activating the miR-17-5p/PTEN/PI3K/Akt signaling pathway. This mechanism has led to the amelioration of cerebral neurovascular injury in aged ischemic stroke mice [ 103 ]. These findings suggest that proteins contained within ECs hold therapeutic promise for CVDs.…”
Section: Contents Of Epc-evsmentioning
confidence: 99%
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“…[ 13 ] MiR‐17‐5p has been recognized as a crucial mediator of many diseases through the optimization of cellular functions. [ 14 , 15 , 16 ] For example, miR‐17‐5p was found to have therapeutic effects for brain tissue damage, [ 17 ] and osteoarthritis. [ 18 ] Furthermore, overexpression of miR‐17‐5p was found to protect from high glucose (HG)‐induced endothelial cell injury.…”
Section: Introductionmentioning
confidence: 99%
“…Given their excellent biological characteristics, including biocompatibility, stability, low toxicity, low immunogenicity, and efficient exchange of molecular cargos, exosomes can be potentially applied for disease treatment ( Patel et al, 2021 ; Wan et al, 2022 ; Xie et al, 2022 ). Recent studies demonstrated that exosomes derived from berberine-pretreated astrocytes, bone marrow-derived mesenchymal stem cells, endothelial progenitor cells, and neural stem cells can suppress neuroinflammation after stroke through different mechanisms ( Liu et al, 2021 ; Ding et al, 2023 ; Pan et al, 2023 ; Peng et al, 2023 ). Studies suggested that exosomes have protective effects on the brain by inhibiting inflammatory responses following ischemic stroke and have broad application prospects.…”
Section: Introductionmentioning
confidence: 99%