MiR-181b regulates autophagy in a model of Parkinson’s disease by targeting the PTEN/Akt/mTOR signaling pathway

Jiang, Yongmei; Wang, Yuan; Yang, Shaonan; Bi, Xinran; Pan, Xudong; Ma, Aijun; Li, Wei

doi:10.1016/j.neulet.2018.03.041

Cited by 51 publications

(25 citation statements)

References 31 publications

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“…Autophagy is considered as a lysosomal-dependent degradation way in cells, and it can produce amino acids and fatty acids for cell reusing via the degradation of the injured organelle proteins under the stress conditions [ 14 , 15 ]. Autophagy can be promoted or inhibited by many different signaling pathways, such as the PTEN/AKT/mTOR pathway [ 16 , 17 ]. Accumulating emerging evidence implicates autophagy can facilitate autophagic cell death and have a role in the tumorigenesis [ 18 – 20 ].…”

Section: Introductionmentioning

confidence: 99%

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway

Gao

Zhao

et al. 2018

Aging

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Prostate cancer (PCa) is considered as a common visceral cancer in males and the sixth major cause of cancer-related deaths in males worldwide. Significant diagnostic and therapeutic advances have been made in the past decades. However, an improved understanding of their molecular mechanism is still needed. In the present research, we first detected the expression of miR-146b by quantitative real-time PCR (qRT-PCR) and found that miR-146b expression was increased in PCa. Subsequently, we found that miR-146b play an important role in the viability and proliferation capacity of PCa cells functionally. To explore the mechanism, we performed western blot to examine the autophagy-related markers, and found that miR‑146b may promote autophagy in PCa cells via activation of PTEN/AKT/mTOR signaling pathway. Furthermore, we performed the dual luciferase reporter assay to clarify the relationship between miR-146b and PTEN. In conclusion, this study demonstrated that miR-146b inhibited autophagy in PCa by targeting the PTEN/Akt/mTOR signaling pathway, and it could be a potential candidate for application in the treatment of PCa.

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Section: Introductionmentioning

confidence: 99%

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway

Gao

Zhao

et al. 2018

Aging

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“…In a study combining investigations in PD patient samples and validation in cell models, miR-205 regulated the expression of PD-related leucine-rich repeat kinase 2 (LRRK2), and prevented the defects in neurite outgrowth in LRRK2 mutant neurons [72]. MiR-181b and miR-124 were shown to be involved in inflammatory response and autophagy in PD models [73,74]. Together, these studies support a significant regulation of PD pathogenesis by miRNAs.…”

Section: Functional Roles Of Mirnas In Parkinson's Diseasementioning

confidence: 79%

Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease

Acharya

Salgado-Somoza

Stefanizzi

et al. 2020

IJMS

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Parkinson’s disease (PD) is a complex and heterogeneous disorder involving multiple genetic and environmental influences. Although a wide range of PD risk factors and clinical markers for the symptomatic motor stage of the disease have been identified, there are still no reliable biomarkers available for the early pre-motor phase of PD and for predicting disease progression. High-throughput RNA-based biomarker profiling and modeling may provide a means to exploit the joint information content from a multitude of markers to derive diagnostic and prognostic signatures. In the field of PD biomarker research, currently, no clinically validated RNA-based biomarker models are available, but previous studies reported several significantly disease-associated changes in RNA abundances and activities in multiple human tissues and body fluids. Here, we review the current knowledge of the regulation and function of non-coding RNAs in PD, focusing on microRNAs, long non-coding RNAs, and circular RNAs. Since there is growing evidence for functional interactions between the heart and the brain, we discuss the benefits of studying the role of non-coding RNAs in organ interactions when deciphering the complex regulatory networks involved in PD progression. We finally review important concepts of harmonization and curation of high throughput datasets, and we discuss the potential of systems biomedicine to derive and evaluate RNA biomarker signatures from high-throughput expression data.

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“…As a common physiological process, autophagy is often regulated by multiple signaling pathways, of which Akt/mTOR signaling is the most classical [45,46]. Inhibition of Akt/mTOR signaling is recognized as an effective pathway to promote autophagy and promoting Akt/mTOR signaling could inhibit autophagy [27,47].…”

Section: Discussionmentioning

confidence: 99%

Downregulation of P300/CBP-Associated Factor Attenuates Myocardial Ischemia-Reperfusion Injury Via Inhibiting Autophagy

Qiu¹,

Xu²,

Xia³

et al. 2020

Int. J. Med. Sci.

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Cardiomyocyte autophagy plays an important role in myocardial ischemia-reperfusion injury (MIRI). P300/CBP-associated factor (PCAF) was involved in the regulation of autophagy. However, the role of PCAF in MIRI is currently unknown. This study was to investigate whether downregulation of PCAF attenuate MIRI. The results showed that the expression of PCAF was significantly increased in MIRI in vivo and in vitro. Downregulation of PCAF not only inhibited autophagy and damage of H9c2 cells induced by hypoxia-reoxygenation, but also reduced autophagy and myocardial infarct size during myocardial ischemia-reperfusion in rats. In addition, downregulation of PCAF promoted activation of PI3K/Akt/mTOR signaling pathway in cardiomyocytes during hypoxia-reoxygenation. Wortmannin, a PI3K/Akt inhibitor, could abrogate the effects of downregulation of PCAF on cardiomyocytes autophagy. These results demonstrated that downregulation of PCAF alleviated MIRI by inhibiting cardiomyocyte autophagy through PI3K/Akt/mTOR signaling pathway. Thus, PCAF may be a potential target for prevention and treatment of MIRI.

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MiR-181b regulates autophagy in a model of Parkinson’s disease by targeting the PTEN/Akt/mTOR signaling pathway

Cited by 51 publications

References 31 publications

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway

Non-Coding RNAs in the Brain-Heart Axis: The Case of Parkinson’s Disease

Downregulation of P300/CBP-Associated Factor Attenuates Myocardial Ischemia-Reperfusion Injury Via Inhibiting Autophagy

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