miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression

Zhang, Hongtuan; Qi, Shiyong; Zhang, Tao; Wang, Yuzhuo; Liu, Ranlu; Guo, Jia; Xu, Yong

doi:10.18632/oncotarget.3341

Cited by 85 publications

(97 citation statements)

References 45 publications

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“…Decreased expression of miR-188-5p is associated with poor prognosis in patients with PCa, which strongly suggests a potential role of miR-188-5p in suppression of PCa. 38 In summary, our findings are the first to show an association between LAPTM4B polymorphism and risk of PCa in a sample of the Iranian population. Further studies with larger sample sizes and different ethnicities are required to validate our findings.…”

Section: Discussionmentioning

confidence: 52%

“…It has been shown that miR-188-5p, which acts as a tumor suppressor, inhibits PCa cell proliferation, invasion, and migration through downregulation of LAPTM4B by directly binding to its 3 0 -UTR 38 and subsequent inhibition of the PI3K/AKT signaling pathway. Decreased expression of miR-188-5p is associated with poor prognosis in patients with PCa, which strongly suggests a potential role of miR-188-5p in suppression of PCa.…”

Section: Discussionmentioning

confidence: 99%

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Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

Hashemi

Rezaei

Narouie

et al. 2016

Molecular & Cellular Oncology

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Lysosome associated protein transmembrane 4 b (LAPTM4B) is an oncogene associated with many human cancers. In the present study we aimed to examine the possible association between LAPTM4B polymorphism and risk of prostate cancer (PCa) in an Iranian population. This case control study was performed on 168 patients with PCa and 176 controls with benign prostatic hyperplasia (BPH). Genomic DNA was extracted from whole blood and LAPTM4B genotypes were identified by polymerase chain reaction. The distributions of LAPTM4B genotypes were significantly different between PCa patients (60.7% for Ã 2 was associated with a decreased risk of PCa but the clinicopathological characteristics of PCa were not linked to LAPTM4B polymorphism. Further studies with larger sample sizes and different ethnicities are needed to confirm our findings.

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

Hashemi

Rezaei

Narouie

et al. 2016

Molecular & Cellular Oncology

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“…The remaining 11 miRNAs have never been studied in liver cancer (Table III). Among the 11 differentially dysregulated miRNAs, the function of miR-374a, miR-188-5p, miR-1183, miR-454, miR-324-3p, miR-484, miR-3188, and miR-216b have been studied in human cancers (27,(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43); however, the exact function of miR-4271, miR-1471 and miR-3610 remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study indicated that miR-1183 and miR-188-5p may represent specific predictors of response to chemoradiotherapy in rectal cancer (32). miR-188-5p is involved in the process of prostate cancer by regulating lysosomal protein transmembrane 4 β (LAPTM4B) (33). The downregulation of miR-188-5p is an independent prognostic factor for poor overall and biochemical recurrence-free survival rates, restoration of miR-188-5p in prostate cancer (PCa) cells significantly suppresses proliferation, migration and invasion in vitro and inhibits tumor growth and metastasis in vivo (33); Overexpression of miR-188-5p in PC-3 cells may significantly enhance the chemosensitivity of the cells to adriamycin (33).…”

Section: Discussionmentioning

confidence: 99%

“…miR-188-5p is involved in the process of prostate cancer by regulating lysosomal protein transmembrane 4 β (LAPTM4B) (33). The downregulation of miR-188-5p is an independent prognostic factor for poor overall and biochemical recurrence-free survival rates, restoration of miR-188-5p in prostate cancer (PCa) cells significantly suppresses proliferation, migration and invasion in vitro and inhibits tumor growth and metastasis in vivo (33); Overexpression of miR-188-5p in PC-3 cells may significantly enhance the chemosensitivity of the cells to adriamycin (33). The miR-188-5p/LAPTM4B/ phosphoinositide-3 kinase/protein kinase B regulatory network performs an important role in PCa progression and chemotherapeutic drug sensitivity (33).…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection

Zhang

et al. 2017

Oncology Letters

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Abstract. Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression profiles of 3 patients with HCC with familial aggregation of HCC and HBV infection and 1 healthy volunteer were examined by microarray analysis, in order to identify relevant miRNAs involved in the pathogenesis of HCC with familial aggregation and HBV infection. The results indicated that 26 miRNAs exhibited a ≥20-fold increase or decrease in the plasma of patients with HCC, compared with the healthy control (24 upregulated and 2 downregulated). Among these altered miRNAs, 15 of them have been reported in HCC. The other 11 miRNAs have never been reported in HCC. These differentially-expressed miRNAs may be potential molecular markers for HCC pathogenesis and development.

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Genetic variants in microRNA‐binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx

Zhu

Zhang

et al. 2017

Intl Journal of Cancer

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The incidence of squamous cell carcinoma of the oropharynx (SCCOP) continues to rise because of increasing rates of human papillomavirus (HPV) infection. Inherited polymorphisms in DNA repair pathways may influence the risk of SCCOP development and the prognosis of SCCOP. We sought to determine whether polymorphisms in microRNA (miRNA)-binding sites within 3' -untranslated regions (3’UTRs) of genes in DNA repair pathways modulate the risk of SCCOP recurrence. We evaluated the associations between nine such polymorphisms and SCCOP recurrence in 1008 patients with incident SCCOP using the log-rank test and multivariable Cox models. In an analysis of all the patients, patients with variant genotypes of BRCA1 rs12516 and RAD51 rs7180135 had better disease-free survival (log-rank, P = 0.0002 and P = 0.0003, respectively) and lower risk of SCCOP recurrence (hazard ratio [HR], 0.5, 95% confidence interval [CI], 0.2-0.8, and HR, 0.5, 95% CI, 0.3-0.9, respectively) than patients with common homozygous genotypes of the two polymorphisms after multivariable adjustment. Moreover, in tumor HPV16-positive patients, patients with variant genotypes of the same two polymorphisms also had better disease-free survival (log-rank, P = 0.004 and P = 0.003, respectively) and lower recurrence risk (HR, 0.2, 95% CI, 0.1-0.6, and HR, 0.2, 95% CI, 0.0-0.7, respectively) than patients with common homozygous genotypes of the two polymorphisms. No such significant associations were found for other polymorphisms. These findings support significant roles of BRCA1 rs12516 and RAD51 rs7180135 in modifying the risk of recurrence of SCCOP, particularly HPV16-positive SCCOP. However, these results must be validated in larger studies.

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miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression

Cited by 85 publications

References 45 publications

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

Association between LAPTM4B gene polymorphism and prostate cancer susceptibility in an Iranian population

MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection

Genetic variants in microRNA‐binding sites of DNA repair genes as predictors of recurrence in patients with squamous cell carcinoma of the oropharynx

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