miR-191: an emerging player in disease biology

Nagpal, Neha; Kulshreshtha, Ritu

doi:10.3389/fgene.2014.00099

Cited by 152 publications

(123 citation statements)

References 82 publications

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“…This confirms that ASC and MSC EVs have both pro-angiogenic properties [11,24] and are able to restore tube formation ability in endothelial cells damaged by high glucose conditioning. These biological effects are consistent with previous observation that MSC EVs and ASC EVs contain several proangiogenic factors [11][12][13][14][24][25][26][27] and miRNAs [20][21][22]46]. …”

Section: Resultssupporting

confidence: 93%

“…Recent studies showed that EVs derived from MSC (MSC EVs) contain vascular endothelial growth factor (VEGF), transforming growth factor β1 (TGFβ1), interleukin 8 (IL-8) [12,13], hepatocyte growth factor (HGF) [14][15][16], HES Family BHLH transcription factor 1 (HES1) [17], and human T-cell factor 4 (TCF4) [18,19], but also miRNA stimulating angiogenesis, such as miR210, miR-126, miR-132, miR-21 [20], miR-222, let-7f [21,22], and cell-cycle progression and proliferation, such as miR-191, miR-222, miR-21, let-7a [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Protective Role of Stem Cell Derived Extracellular Vesicles in an In Vitro Model of Hyperglycemia-Induced Endothelial Injury

Gai¹,

Gomez²,

Tetta³

et al. 2017

J Cell Sci Ther

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Background: Adipose and bone marrow derived mesenchymal stem cells are two populations of multipotent adult stem cells with immunosuppressive, anti-inflammatory, and regenerative properties. It has been previously described that extracellular vesicles (EVs) derived from stem cells possess pro-regenerative and pro-angiogenic abilities. Hyperglycemia is a pathological condition affecting diabetic patients. Long term effects of hyperglycemia are endothelial dysfunction and vascular lesions leading to diabetic microangiopathy.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Protective Role of Stem Cell Derived Extracellular Vesicles in an In Vitro Model of Hyperglycemia-Induced Endothelial Injury

Gai¹,

Gomez²,

Tetta³

et al. 2017

J Cell Sci Ther

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“…miR-191 is a stress-sensitive miRNA that has been extensively studied in cancer pathologies and reduced levels of this miRNA are shown in connection with diabetes mellitus. 16,23 Modulation in miR-191 expression regulates apoptosis, cell proliferation, migration, and cell cycle under various pathological settings. 23 Interestingly, altered plasma levels of endothelial-rich miRNAs, for example, miR-191 or miR-126 is reported to reflect underlying endothelial dysfunction in diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

“…16,23 Modulation in miR-191 expression regulates apoptosis, cell proliferation, migration, and cell cycle under various pathological settings. 23 Interestingly, altered plasma levels of endothelial-rich miRNAs, for example, miR-191 or miR-126 is reported to reflect underlying endothelial dysfunction in diabetes mellitus. 16 miR-191 is coexpressed with the miR-191/425 cluster which is highly conserved in higher eukaryotes 24 and our plasma miRNA profiles also confirm a unidirectional changes in circulating plasma levels of both clustered miRNAs from patients with diabetes mellitus with impaired wound healing compared with diabetics with no chronic wound.…”

Section: Discussionmentioning

confidence: 99%

Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines

Dangwal

Stratmann

Bang

et al. 2015

ATVB

131

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Objective— MicroRNAs (miRNA/miR) are stably present in body fluids and are increasingly explored as disease biomarkers. Here, we investigated influence of impaired wound healing on the plasma miRNA signature and their functional importance in patients with type 2 diabetes mellitus. Approach and Results— miRNA array profiling identified 41 miRNAs significantly deregulated in diabetic controls when compared with patients with diabetes mellitus–associated peripheral arterial disease and chronic wounds. Quantitative real-time polymerase chain reaction validation confirmed decrease in circulating miR-191 and miR-200b levels in type 2 diabetic versus healthy controls. This was reverted in diabetic subjects with associated peripheral arterial disease and chronic wounds, who also exhibited higher circulating C-reactive protein and proinflammatory cytokine levels compared with diabetic controls. miR-191 and miR-200b were significantly correlated with C-reactive protein or cytokine levels in patients with diabetes mellitus. Indeed, proinflammatory stress increased endothelial- or platelet-derived secretion of miR-191 or miR-200b. In addition, dermal cells took up endothelial-derived miR-191 leading to downregulation of the miR-191 target zonula occludens-1. Altered miR-191 expression influenced angiogenesis and migratory capacities of diabetic dermal endothelial cells or fibroblasts, respectively, partly via its target zonula occludens-1. Conclusions— This study reports that (1) inflammation underlying nonhealing wounds in patients with type 2 diabetes mellitus influences plasma miRNA concentrations and (2) miR-191 modulates cellular migration and angiogenesis via paracrine regulation of zonula occludens-1 to delay the tissue repair process.

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“…The majority of miRs negatively regulate the expression of their target genes by binding to the 3'-untranslated regions (3'-UTRs) of mRNA, leading to mRNA degradation or translational suppression (11,12). In numerous biological processes, including cell proliferation, differentiation, migration and apoptosis, miRs are involved in regulating the expression of multiple target genes (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

miR-143 suppresses the proliferation of NSCLC cells by inhibiting the epidermal growth factor receptor

Zhang

Sun

Ling

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. MicroRNAs (miRs) regulate the proliferation and metastasis of numerous cancer cell types. It was previously reported that miR-143 levels were downregulated in non-small cell lung cancer (NSCLC) tissues and cell lines, and that the migration and invasion of NSCLC cells was inhibited upon suppression of cell proliferation and colony formation by the upregulation of miR-143. Epidermal growth factor receptor (EGFR), which is a vital factor in the promotion of cancer cell proliferation and has been investigated as a potential focus in cancer therapy, has been reported to be a possible target of miR-143. The present study aimed to investigate the role of miR-143 in NSCLC using NSCLC cell lines and primary cells from NSCLC patients. NSCLC cells were co-transfected with EGFR and miR-143, and the mRNA and protein expression of EGFR were analyzed. Furthermore, the activity of the transfected cancer cells with regard to colony formation, migration, invasion and apoptosis were evaluated. The levels of miR-143 were decreased in the NSCLC cell lines and primary cells from patients with NSCLC compared with the controls. Following transfection with miR-143, the ability of NSCLC cells to proliferate, form colonies, migrate and invade was inhibited. Similarly, knockdown of EGFR led to the suppression of NSCLC cell proliferation. The mRNA and protein expression levels of EGFR were significantly reduced following miR-143 overexpression, and the level of miR-143 was inversely correlated with that of EGFR in NSCLC cells. The results of the present study demonstrated that miR-143 was able to suppress NSCLC cell proliferation and invasion by inhibiting the effects of EGFR, suggesting that EGFR may be considered a potential target for NSCLC therapy.

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miR-191: an emerging player in disease biology

Cited by 152 publications

References 82 publications

Protective Role of Stem Cell Derived Extracellular Vesicles in an In Vitro Model of Hyperglycemia-Induced Endothelial Injury

Protective Role of Stem Cell Derived Extracellular Vesicles in an In Vitro Model of Hyperglycemia-Induced Endothelial Injury

Impairment of Wound Healing in Patients With Type 2 Diabetes Mellitus Influences Circulating MicroRNA Patterns via Inflammatory Cytokines

miR-143 suppresses the proliferation of NSCLC cells by inhibiting the epidermal growth factor receptor

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