MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1

Wu, Qiong; Yang, Ziyan; An, Yu; Hu, Hao; Yin, Jiaqi; Zhang, P; Nie, Yongzhan; Wu, Kaichun; Shi, Yongquan; Fan, Daiming

doi:10.1038/cddis.2014.110

Cited by 105 publications

(100 citation statements)

References 30 publications

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“…It has been reported that miR-19 was dysregulated in various cancers, and miR-19 upregulation strongly correlated with gain of invasive and metastatic properties and poor prognosis of patients with NSCLC, [11][12][13] gastric cancer, 14 and esophageal squamous cell carcinoma. 15 Moreover, the expression of miR-19 was significantly higher in the lessinvasive breast cancer MCF7 cells than the more-invasive MDAMB-231 cells, and the expression of a positive regulator of tumor angiogenesis and metastasis was negatively regulated by miR-19 in breast cancer cells, 35 suggesting that miR-19 inhibited the metastasis of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have also reported that upregulation of miR-19a and miR-19b-1 was associated with cancer invasion and metastasis, and poor prognosis of patients with early non-small-cell lung carcinoma (NSCLC), [11][12][13] gastric cancer, 14 and esophageal squamous cell carcinoma. 15 In addition, high levels of serum miR-19a and miR-19b-1 were considered as independent prognostic factors for poor survival of NSCLC patients.…”

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confidence: 99%

“…Given that miR-19 is associated with cancer invasion and metastasis and EMT is the central mechanism underlying cancer invasion and metastasis, [10][11][12][13][14][15][16][17][18] the present study aimed to investigate whether miR-19 is able to induce EMT and enhance invasion and metastasis of human cancer cells. Our results showed that enforced expression of miR-19 in lung cancer cells induced EMT, which caused growth inhibition but elevated migration of the cancer cells.…”

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confidence: 99%

“…12,13 In a mouse model of c-Myc-driven B-cell lymphomas, Em-myc/miR-19b-1 lymphomas are highly invasive as lymphoma cells invaded the thymus and bone marrow, as well as visceral organs outside the lymphoid compartment, including the liver, lung, and, occasionally, the kidney. 10 More recent studies have reported that miR-19a or miR-19b-1 promoted the migration and invasion of cervical carcinoma cells, 16 colon cancer cells, 17 and gastric cancer cells through targeting the tumor suppressor MXD1, 14 and Hela, MCF7, and Huh7 cells through targeting TP53. 18 Taken together, these results support that miR-19 is involved in cancer invasion and metastasis; however, the underlying mechanisms remain largely unknown.…”

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confidence: 99%

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MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

Yang

Yan

et al. 2015

Laboratory Investigation

103

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The miR-19 family (miR-19a and miR-19b-1) are key oncogenic components of the miR-17-92 cluster. Overexpression of miR-19 is strongly associated with cancer invasion and metastasis, and poor prognosis of cancer patients. However, the underlying mechanisms remain largely unknown. In the present study, we found that enforced expression of miR-19 including miR-19a and miR-19b-1 triggered epithelial-mesenchymal transition (EMT) of lung cancer cells A549 and HCC827 as shown by mesenchymal-like morphological conversion, downregulation of epithelial proteins (e.g., E-cadherin, ZO-1 (zona occludens 1), and α-catenin), upregulation of mesenchymal proteins (e.g., vimentin, fibronectin 1, N-cadherin, and snail1), formation of stress fibers, and reduced cell adhesion. In addition, enhanced migration and invasion were observed in the cancer cells A549 and HCC827 undergoing EMT. In contrast, silencing of endogenous miR-19 reversed EMT and reduced the migration and invasion abilities of A549 and HCC827 cells. DNA microarray results revealed significant changes of the expression of genes related to EMT, migration, and metastasis of miR-19-expressing A549 cells. Moreover, siRNA-mediated knockdown of PTEN, a target of miR-19, also resulted in EMT, migration, and invasion of A549 and HCC827 cells, suggesting that PTEN is involved in miR-19-induced EMT, migration and invasion of lung cancer cells. Furthermore, lung cancer cells undergoing EMT induced by miR-19 demonstrated reduced proliferation in vitro and in vivo, and enhanced resistance to apoptosis caused by TNF-α. Taken together, these findings suggest that miR-19 triggers EMT, which has an important role in the invasion and migration of lung cancer cells, accompanied by the reduced proliferation of cells.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

Yang

Yan

et al. 2015

Laboratory Investigation

103

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“…MiR‐17‐92 cluster is regarded as the first miRNA cluster with oncogenic potential,15 the cluster includes 6 single mature miRNAs, miR‐19 has been supposed to be the key oncogenic miRNA among the six members of miR‐17‐92 cluster. MiR‐19 is located on chromosome 13 in c13orf25 16 and its expression is up‐regulated in bladder cancer, breast cancer, pancreatic cancer, gastric cancer and laryngeal squamous cell carcinoma 17, 18, 19, 20, 21. MiR‐19 promotes tumourigenesis by regulating target genes and related signalling pathways.…”

Section: Introductionmentioning

confidence: 99%

The emerging role of miR‐19 in glioma

Wang

Zhang

Hao

et al. 2018

J Cellular Molecular Medi

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Glioma has been regarded as the most common, highly proliferative and invasive brain tumour. Advances in research of miRNAs in glioma are toward further understanding of the pathogenesis of glioma. MiR‐19, a member of miR‐17~92 cluster, was reported to play an oncogenic role in tumourigenesis. Here we review the identified data about the effect of miR‐19 on proliferation, apoptosis, migration and invasion of glioma cells, the target genes regulated by miR‐19, and correlation of miR‐19 with the sensitivity of glioma cells to chemotherapy and radiotherapy. It is concluded that miR‐19 plays an important role in the pathogenesis of glioma and can be a potential target for gene therapy of glioma.

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Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation

Ishimoto

Baba

Izumi

et al. 2015

Intl Journal of Cancer

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Acquired genetic and epigenetic alterations in normal cells give rise to transformed cells, which lead to tumor development. Elucidation of the precise mechanisms underlying primary and metastatic tumor formation is required. MicroRNAs (miRNAs) are small noncoding RNAs that play a major role in post-transcriptional gene regulation during various biological processes. Accumulating evidence suggests that dysregulation of miRNAs is intimately involved in the carcinogenesis, progression and metastasis of many cancers, including gastric cancers (GCs), while the alteration of certain miRNAs provides biomarkers to detect early GCs. This review summarizes the most recent findings into the mechanisms of miRNA-mediated regulation of GCs, which will support the development of diagnostic biomarkers and novel therapeutic strategies.Gastric cancer (GC) is the fifth most prevalent type of malignancy and the third leading cause of cancer-related death worldwide. 1 The major histological type of GC is gastric adenocarcinoma, which can be further divided into intestinal and diffuse types according to the Lauren classification. 2 Although most GCs are sporadic and caused by infection, such as those caused by Helicobacter pylori bacteria or Epstein-Barr virus (EBV), a small number of GC cases are associated with heritable mutations in particular genes, including E-cadherin (CDH1) or mismatch repair genes (Lynch syndrome). 3,4 Despite recent advances in diagnostic modalities, such as computed tomographic scanning, endoscopic screening and the development of molecular-targeted drugs, the median overall survival of patients with advanced GC is still 11.3-13.8 months, according to recent Phase 3 trials. 5-7 Therefore, understanding the precise molecular mechanisms underlying GC progression is crucial for the development of novel therapeutic strategies for patients with GC.

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MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1

Cited by 105 publications

References 30 publications

MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

MicroRNA-19 triggers epithelial–mesenchymal transition of lung cancer cells accompanied by growth inhibition

The emerging role of miR‐19 in glioma

Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation

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